Alcoholic Cardiomyopathy

Sander, Michael; Heymann, C. von; Spies, Claudia; Braun, J.; Borges, Adrian C.

doi:10.1016/b978-012564370-2/50053-2

Cited by 2 publications

(1 citation statement)

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“…alcoholic cardiomyopathy with dilatation of the left ventricle. 5 Hepatomegaly caused by increased hepatocytes intracellular cell volume is also understood to be linked to alcohol abuse. 6 Antigenic stimulation consequent of chronic introduction of various antigens via injections has been suggested as a possible cause of splenomegaly found in some drug users.…”

Section: Introductionmentioning

confidence: 99%

Heart, liver and spleen pathology in chronic alcohol and drug users

Wong

Viana

Squires

2008

Journal of Forensic and Legal Medicine

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Section: Introductionmentioning

confidence: 99%

Heart, liver and spleen pathology in chronic alcohol and drug users

Wong

Viana

Squires

2008

Journal of Forensic and Legal Medicine

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Quantifying the global contribution of alcohol consumption to cardiomyopathy

Manthey

Imtiaz

Neufeld

et al. 2017

Popul Health Metrics

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BackgroundThe global impact of alcohol consumption on deaths due to cardiomyopathy (CM) has not been quantified to date, even though CM contains a subcategory for alcoholic CM with an effect of heavy drinking over time as the postulated underlying causal mechanism. In this feasibility study, a model to estimate the alcohol-attributable fraction (AAF) of CM deaths based on alcohol exposure measures is proposed.MethodsA two-step model was developed based on aggregate-level data from 95 countries, including the most populous (data from 2013 or last available year). First, the crude mortality rate of alcoholic CM per 1,000,000 adults was predicted using a negative binomial regression based on prevalence of alcohol use disorders (AUD) and adult alcohol per capita consumption (APC) (n = 52 countries). Second, the proportion of alcoholic CM among all CM deaths (i.e., AAF) was predicted using a fractional response probit regression with alcoholic CM crude mortality rate (from Step 1), AUD prevalence, APC per drinker, and Global Burden of Disease region as predictions. Additional models repeated these steps by sex and for the wider Global Burden of Disease study definition of CM.ResultsThere were strong correlations (>0.9) between the crude mortality rate of alcoholic CM and the AAFs, supporting the modeling strategy. In the first step, the population-weighted mean crude mortality rate was estimated at 8.4 alcoholic CM deaths per 1,000,000 (95% CI: 7.4–9.3). In the second step, the global AAFs were estimated at 6.9% (95% CI: 5.4–8.4%). Sex-specific figures suggested a lower AAF among females (2.9%, 95% CI: 2.3–3.4%) as compared to males (8.9%, 95% CI: 7.0–10.7%). Larger deviations between observed and predicted AAFs were found in Eastern Europe and Central Asia.ConclusionsThe model proposed promises to fill the gap to include AAFs for CM into comparative risk assessments in the future. These predictions likely will be underestimates because of the stigma involved in all fully alcohol-attributable conditions and subsequent problems in coding of alcoholic CM deaths.Electronic supplementary materialThe online version of this article (doi:10.1186/s12963-017-0137-1) contains supplementary material, which is available to authorized users.

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Alcoholic Cardiomyopathy

Cited by 2 publications

References 91 publications

Heart, liver and spleen pathology in chronic alcohol and drug users

Heart, liver and spleen pathology in chronic alcohol and drug users

Quantifying the global contribution of alcohol consumption to cardiomyopathy

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