Alcoholic Cardiomyopathy: Pathophysiologic Insights

Piano, Mariann R.; Phillips, Shane A.

doi:10.1007/s12012-014-9252-4

Cited by 169 publications

(168 citation statements)

References 93 publications

(165 reference statements)

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“…Alcoholic cardiomyopathy (ACM), which is characterized by cardiac hypertrophy and compromised myocardial contractility associated with chronic alcohol consumption, has long been recognized as one of the major toxicological effects of ethanol in the cardiovascular system (Guzzo-Merello et al 2015;Piano and Phillips 2014). The link between alcoholism and left ventricle dysfunction has been reported in heart disease (Guzzo-Merello et al 2014;Guzzo-Merello et al 2015;Piano and Phillips 2014).…”

Section: Introductionmentioning

confidence: 99%

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Increased expression of microRNA-378a-5p in acute ethanol exposure of rat cardiomyocytes

Wang

Song

Zhang

et al. 2017

Cell Stress and Chaperones

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Alcohol abuse is a risk factor for a distinct form of congestive heart failure, known as alcoholic cardiomyopathy (ACM). Here, we investigate how microRNAs may participate in the induction of cardiomyocyte apoptosis associated with ethanol exposure in vitro. Increasing the concentrations of ethanol to primary rat cardiomyocytes resulted in elevated apoptosis assessed by annexin V and propidium iodide staining, and reduced expression of an enzyme for alcohol detoxification aldehyde dehydrogenase 2 (ALDH2). These ethanol effects were accompanied by a substantial elevation of miR378a-5p. Driving miR-378a-5p overexpression in cardiomyocytes decreased ALDH2. The specific interaction of miR-378a-5p with the 3'UTR of ALDH2 was examined by luciferase reporter assays, and we found that miR-378a-5p activity depends on a complementary base pairing at the 3′-UTR region of ALDH2 mRNA. Finally, ethanol-induced apoptosis in cardiomyocytes was attenuated in the presence of anti-miR378a-5p. Collectively, these data implicate a likely involvement of miR-378a-5p in the stimulation of cardiomyocyte apoptosis through ALDH2 gene suppression, which might play a potential role in the pathogenesis of ACM.

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Section: Introductionmentioning

confidence: 99%

“…The link between alcoholism and left ventricle dysfunction has been reported in heart disease (Guzzo-Merello et al 2014;Guzzo-Merello et al 2015;Piano and Phillips 2014). For instance, the incidence of congestive cardiomyopathy is greatly enhanced in populations of patients involved with ethanol addiction (Fernandez-Sola 2015).…”

Section: Introductionmentioning

confidence: 99%

Increased expression of microRNA-378a-5p in acute ethanol exposure of rat cardiomyocytes

Wang

Song

Zhang

et al. 2017

Cell Stress and Chaperones

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“…Clinical diagnosis is generally made in heavy drinkers with myocardial dysfunction in the absence of other identified causes (5). Ethanol intake ≥24 g per day in females and ≥36 g per day in males has been found to cause hypertension; therefore, hypertension frequently contributes to LV dysfunction in cases of cardiomyopathy (6).…”

Section: Discussionmentioning

confidence: 99%

A Case of Ischemic Cerebellar Stroke with Alcoholic Cardiomyopathy

Akinci¹,

Özer²,

Urgun³

et al. 2017

tnd

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“…ACM is a cardiac disease found in individuals exposed to high levels of alcohol consumption for a long period, which can lead to cardiac dysfunctions and heart failure [21,22]. Lazarevic et al [23 ]have found that alcoholics (with alcohol consumption >90 g/day, ≥4 days/week) have a significant increase in LV diameter and volume, but did not observe any differences in systolic function.…”

Section: Discussionmentioning

confidence: 99%

Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy

Jing

Jin

Lü³

et al. 2015

Cardiology

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Objectives: We aimed to investigate the differentially expressed microRNAs (miRNAs) and their target genes in human alcoholic cardiomyopathy (ACM). Methods: The expression levels of plasma miRNAs of 78 male ACM patients and 78 healthy men were detected by using the 6th-generation miRCURY™ LNA array (v.16.0). The prediction analysis for microarrays (PAM) method was used to identify the differentially expressed miRNAs. Target genes of the identified differentially expressed miRNAs were predicted using TargetScan 5.2 and Miranda. Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to perform functional annotation and pathway enrichment analysis of target genes respectively, followed by real-time RT-PCR analysis to validate the expression changes of miRNAs. Results: Twenty-one differentially expressed miRNAs were identified. Nine differentially expressed miRNAs (hsa-miR-506, hsa-miR-1285, hsa-miR-512-3P, hsa-miR-138, hsa-miR-485-5P, hsa-miR-4262, hsa-miR-548c-3P, has-miR-548a-5P and kshv-miR-K12-1), involved in multiple functions and pathways, were selected for real-time RT-PCR confirmation. Moreover, two significantly important subpathways (neurotrophin signaling pathway and inositol phosphate metabolism) were predicted. Conclusion: The screened differentially expressed miRNAs may be involved in the development of ACM. Specific miRNAs, such as miR-138, may be considered as a new target for the early diagnosis and treatment of human ACM.

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Alcoholic Cardiomyopathy: Pathophysiologic Insights

Cited by 169 publications

References 93 publications

Increased expression of microRNA-378a-5p in acute ethanol exposure of rat cardiomyocytes

Increased expression of microRNA-378a-5p in acute ethanol exposure of rat cardiomyocytes

A Case of Ischemic Cerebellar Stroke with Alcoholic Cardiomyopathy

Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy

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