Alcoholic Cardiomyopathy: Translation Model

Крыжановский, С. А.; Колик, Л. Г.; Цорин, И. Б.; Stolyaruk, V. N.; Вититнова, М. Б.; Ионова, Е. О.; Сорокина, А. В.; Дурнев, А. Д.

doi:10.1007/s10517-017-3865-0

Cited by 18 publications

(9 citation statements)

References 4 publications

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“…Moreover, the fact that alcoholic cardi-omyopathy induces dilation of both the left and right ventricles is consistent with the biventricular systolic dysfunction in this case. 16,17) Based on these reasons, we believe that alcoholic cardiomyopathy is most likely. Beriberi heart could have coexisted due to vitamin B1 deficiency, although vitamin B1 was not measured at admission.…”

Section: Discussionmentioning

confidence: 96%

Biventricular Thrombi Associated with Cardiac Systolic Dysfunction and Disseminated Intravascular Coagulation from Heat Stroke

et al. 2021

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A 58-year-old man with non-ischemic cardiomyopathy visited a hospital once a month after his first hospitalization for heart failure. Three months later, he presented with consciousness impairment and heat stroke. Blood tests showed multiple organ failure, and echocardiography revealed biventricular thrombi. After admission, intensive care was provided, and anticoagulation therapy was initiated. The echocardiographic findings in the third week confirmed the complete disappearance of thrombi. Biventricular thrombi associated with disseminated intravascular coagulation from heat stroke is rare. We report the case of a patient who was treated with anticoagulation therapy only, without surgical intervention.

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Section: Discussionmentioning

confidence: 96%

Biventricular Thrombi Associated with Cardiac Systolic Dysfunction and Disseminated Intravascular Coagulation from Heat Stroke

et al. 2021

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“…Alcohol abuse can cause systemic atherosclerosis [ 49 ], high blood pressure (HBP) [ 50 ] and cardiac arrhythmias. However, in a very high percentage, it leads to progressive myocardial damage, also known as “alcohol dilated heart disease” [ 14 , 24 , 30 , 51 , 52 , 53 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

Death-causing cardiac injuries after chronic alcohol intake identified by forensic medicine

Crauciuc

Stan²,

Rîşcanu³

et al. 2022

Rom J Morphol Embryol

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Ethyl alcohol is the most consumed drug, worldwide, with frequent consequences on the individual’s health and lifestyle. Chronic alcoholism is a pathological state occurring after an excessive alcohol intake and may be observed in teenagers or very old individuals. The study performed by us investigated the changes caused by alcohol intake in the left ventricle myocardium in 77 bodies deceased at home under suspect circumstances and sent to the Institute of Forensic Medicine for establishing the cause of death. In all the individuals, there was determined high levels of blood Ethyl glucuronide, thus showing the alcohol intake up to 96 hours before death. The lesions present in the heart were represented by dilated cardiomyopathy, myocardial fibrosis, and myocardial infarction.

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“…Twenty‐four 8‐week‐old male C57BL/6 mice (Beijing Vital River Laboratory Animal Technology Co., Ltd., Beijing, China) were randomly divided into 2 ethanol (EtOH)‐fed groups and 2 control‐fed groups (non‐EtOH fed) ( n = 6 for all groups). In EtOH‐fed groups, mice were fed a 4%‐EtOH (w/v, 28% of total calories) alcoholic liquid diet of Lieber–DeCarli or AIN‐93 for chronic alcohol exposure for 180 days (Bertola et al., ; Kryzhanovskii et al., ; Matyas et al., ; Yang et al., ). In control‐fed groups, mice were fed with non‐EtOH liquid diets, with an equal number of calories as the EtOH‐fed groups.…”

Section: Methodsmentioning

confidence: 99%

AIN‐93 Diet as an Alternative Model to Lieber–DeCarli Diet for Alcoholic Cardiomyopathy

Cao

Zhang

et al. 2019

Alcoholism Clin & Exp Res

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Background: The Lieber-DeCarli alcoholic liquid diet is a classical method for establishing animal models of alcoholic cardiomyopathy (ACM). No study has reported whether the AIN-93 diet, which is widely used as a standard diet for both long-term and short-term studies with laboratory animals, could be used to construct the ACM animal model. The present study intended to investigate whether the AIN-93 diet could be used to establish a mouse ACM model.Methods: Twenty-four C57BL/6 male mice were randomly divided into 4 equally sized groups. In ethanol (EtOH)-fed groups, mice were fed a 4%-EtOH (w/v, 28% of total calories) alcoholic liquid diet of Lieber-DeCarli or the AIN-93 diet for chronic alcohol exposure for 180 days. In control-fed groups, mice were fed with non-EtOH liquid diets with the same calories as EtOH-fed groups. Morphological observations of the hearts and molecular investigation of the brain natriuretic peptide (BNP) were carried out by echocardiography, hematoxylin and eosin (H&E) and immunohistochemistry (IHC) staining, real-time quantitative polymerase chain reaction (qPCR), and enzyme-linked immunosorbent assay.Results: Echocardiography showed that mice fed with either the 4%-EtOH Lieber-DeCarli diet or the 4%-EtOH AIN-93 diet had dilated ventricles and poor cardiac function. IHC staining of BNP, qPCR of BNP mRNA, and plasma concentration of BNP showed an up-regulated expression in mice fed with both the 4%-EtOH Lieber-DeCarli and 4%-EtOH AIN-93 diets. Less fatty liver was also observed in mice fed the AIN-93 alcoholic diet than those fed the Lieber-DeCarli alcoholic diet.Conclusions: The AIN-93 alcoholic liquid diet can be used to establish ACM animal models, as with the conventional Lieber-DeCarli alcoholic liquid diet.

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Alcoholic Cardiomyopathy: Translation Model

Cited by 18 publications

References 4 publications

Biventricular Thrombi Associated with Cardiac Systolic Dysfunction and Disseminated Intravascular Coagulation from Heat Stroke

Biventricular Thrombi Associated with Cardiac Systolic Dysfunction and Disseminated Intravascular Coagulation from Heat Stroke

Death-causing cardiac injuries after chronic alcohol intake identified by forensic medicine

AIN‐93 Diet as an Alternative Model to Lieber–DeCarli Diet for Alcoholic Cardiomyopathy

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