Alcoholic cerebellar degeneration: A case report

Zeigelboim, Bianca Simone; Santos, Cristiano Albano dos; Teive, Hélio A.G.; Malisky, Jéssica Spricigo; José, Maria Renata; Rosa, Michéli Rodrigues da; Lacerda, Adriana Bender Moreira de

doi:10.1016/j.neucli.2019.10.113

Cited by 2 publications

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“…The onset of cerebellar deficit symptoms occurs in mid-age population with persistent abstinence in alcoholics. 1 Alcoholic cerebellar degeneration is characterized by ataxia of stance and gait, whereby a wide-based gait with shortened steps is adapted to compensate for the loss of balance and unsteadiness experienced.…”

Section: Introductionmentioning

confidence: 99%

Alcohol Induced Cerebellar Ataxia: A Case Report

Pattanashetti¹,

Doddanavar²

2022

JYP

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Consumption of alcohol excessively causes dependence and leads to psychological discomfort. Motivation to drink is influenced by a variety of neurobiological and environmental variables. The proclivity of an individual to imbibe is thought to reflect a balance between alcohol's positive reinforcing (i.e., rewarding) effects, such as euphoria and anxiety reduction (i.e., anxiolysis), and the drug's aversive effects, which are typically associated with negative consequences of alcohol consumption (e.g., hangover or withdrawal symptoms). Neuroadaptive alterations caused by continuous alcohol use and abuse (such as tolerance and physiological dependence) are regarded to be critical in the shift from regulated alcohol use to more frequent and excessive, uncontrollable drinking which induces cerebellar degeneration considered as common type of acquired toxic ataxia. Excessive use leads to degeneration of the midline cerebellum. Progressive trunk and gait ataxia is characteristic, with little involvement of upper limbs, eyes or speech (a corollary of relative cerebellar hemispheric sparing). Abrupt termination of alcohol use after a period of heavy drinking may result in alcohol withdrawal seizures. Generalized tonic-clonic seizures are the most common and severe form of seizure in this conditions. Current case report presents complaints of astasia and slurred speech with few episodes of seizures. The diagnosis indicated Mild cerebellar atrophy. Patient was advised to undergo de-addiction and cure.

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Section: Introductionmentioning

confidence: 99%

Alcohol Induced Cerebellar Ataxia: A Case Report

Pattanashetti¹,

Doddanavar²

2022

JYP

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Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations

Sahu,

Verma,

Bhaskar

2025

World J Exp Med

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Alcohol use disorder (AUD) is a medical condition that impairs a person's ability to stop or manage their drinking in the face of negative social, occupational, or health consequences. AUD is defined by the National Institute on Alcohol Abuse and Alcoholism as a "severe problem". The central nervous system is the primary target of alcohol's adverse effects. It is crucial to identify various neurological disorders associated with AUD, including alcohol withdrawal syndrome, Wernicke-Korsakoff syndrome, Marchiafava-Bignami disease, dementia, and neuropathy. To gain a better understanding of the neurological environment of alcoholism and to shed light on the role of various neurotransmitters in the phenomenon of alcoholism. A comprehensive search of online databases, including PubMed, EMBASE, Web of Science, and Google Scholar, was conducted to identify relevant articles. Several neurotransmitters (dopamine, gamma-aminobutyric acid, serotonin, and glutamate) have been linked to alcoholism due to a brain imbalance. Alcoholism appears to be a complex genetic disorder, with variations in many genes influencing risk. Some of these genes have been identified, including two alcohol metabolism genes, alcohol dehydrogenase 1B gene and aldehyde dehydrogenase 2 gene , which have the most potent known effects on the risk of alcoholism. Neuronal degeneration and demyelination in people with AUD may be caused by neuronal damage, nutrient deficiencies, and blood brain barrier dysfunction; however, the underlying mechanism is unknown. This review will provide a detailed overview of the neurobiology of alcohol addiction, followed by recent studies published in the genetics of alcohol addiction, molecular mechanism and detailed information on the various acute and chronic neurological manifestations of alcoholism for the Future research.

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Alcoholic cerebellar degeneration: A case report

Cited by 2 publications

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Alcohol Induced Cerebellar Ataxia: A Case Report

Alcohol Induced Cerebellar Ataxia: A Case Report

Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations

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