Alcoholic liver disease/nonalcoholic fatty liver disease index

Cerović, Ivana; Mladenović, Dušan; Jesic, Rada; Naumović, Tamara; Branković, Miloš; Vučević, Danijela; Aleksić, Vuk; Radosavljević, Tatjana

doi:10.1097/meg.0b013e32835f0786

Cited by 28 publications

(5 citation statements)

References 37 publications

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“…Meanwhile, Dunn et al more recently reported the alcoholic liver disease (ALD)/non-alcoholic fatty liver disease (NAFLD) index (ANI) for the differentiation of ALD and NAFLD [ 11 ]. ANI is a formula derived from four independent ALD predictors: MCV, the AST/ALT ratio, body mass index (BMI), and male sex that has been reported as capable of distinguishing ALD from NAFLD [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) is more useful than pre-existing laboratory tests for predicting hazardous drinking: a cross-sectional study

Fujii¹,

Nishimoto

Yamaguchi³

et al. 2016

BMC Public Health

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BackgroundIt is important to screen for alcohol consumption and drinking customs in a standardized manner. The aim of this study was 1) to investigate whether the AUDIT score is useful for predicting hazardous drinking using optimal cutoff scores and 2) to use multivariate analysis to evaluate whether the AUDIT score was more useful than pre-existing laboratory tests for predicting hazardous drinking.MethodsA cross-sectional study using the Alcohol Use Disorders Identification Test (AUDIT) was conducted in 334 outpatients who consulted our internal medicine department. The patients completed self-reported questionnaires and underwent a diagnostic interview, physical examination, and laboratory testing.ResultsForty (23 %) male patients reported daily alcohol consumption ≥ 40 g, and 16 (10 %) female patients reported consumption ≥ 20 g. The optimal cutoff values of hazardous drinking were calculated using a 10-fold cross validation, resulting in an optimal AUDIT score cutoff of 8.2, with a sensitivity of 95.5 %, specificity of 87.0 %, false positive rate of 13.0 %, false negative rate of 4.5 %, and area under the receiver operating characteristic curve of 0.97. Multivariate analysis revealed that the most popular short version of the AUDIT consisting solely of its three consumption items (AUDIT-C) and patient sex were significantly associated with hazardous drinking. The aspartate transaminase (AST)/alanine transaminase (ALT) ratio and mean corpuscular volume (MCV) were weakly significant.ConclusionsThis study showed that the AUDIT score and particularly the AUDIT-C score were more useful than the AST/ALT ratio and MCV for predicting hazardous drinking.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-016-3053-6) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) is more useful than pre-existing laboratory tests for predicting hazardous drinking: a cross-sectional study

Fujii¹,

Nishimoto

Yamaguchi³

et al. 2016

BMC Public Health

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“… 1 – 3 Alcoholic liver disease (ALD), induced by excessive alcohol consumption, and nonalcoholic fatty liver disease (NAFLD), caused by obesity and insulin resistance, are the most common diseases associated with hepatic steatosis, although hepatic steatosis is also found in patients with hepatitis C virus infection and those receiving certain medications, such as corticosteroids and amiodarone. 4 , 5 Regardless of etiology, hepatic steatosis can progress to end stage liver disease such as liver cirrhosis or hepatocellular carcinoma. 1 , 6 – 8 Moreover, NAFLD has emerged as one of the risk factors for coronary artery disease and type 2 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Controlled Attenuation Parameter and Hepatic Steatosis as Assessed by Ultrasound in Alcoholic or Nonalcoholic Fatty Liver Disease

et al. 2016

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Background/AimsThe aim of this study was to evaluate the relationship between controlled attenuation parameter (CAP) and hepatic steatosis, as assessed by ultrasound (US) in patients with alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD).MethodsPatients with either ALD or NAFLD who were diagnosed with fatty liver with US and whose CAP scores were measured, were retrospectively enrolled in this study. The degree of hepatic steatosis assessed by US was categorized into mild (S1), moderate (S2), and severe (S3).ResultsA total of 186 patients were included: 106 with NAFLD and 80 with ALD. Regarding hepatic steatosis, the CAP score was significantly correlated with US (ρ=0.580, p<0.001), and there was no significant difference between the NAFLD and ALD groups (ρ=0.569, p<0.001; ρ=0.519, p<0.001; p=0.635). Using CAP, area under receiver operating characteristic curves for ≥S2 and ≥S3 steatosis were excellent (0.789 and 0.843, respectively). For sensitivity ≥90%, CAP cutoffs for the detection of ≥S2 and ≥S3 steastosis were separated with a gap of approximately 35 dB/m in all patients and in each of the NAFLD and ALD groups.ConclusionsThe CAP score is well correlated with hepatic steatosis, as assessed by US, in both ALD and NAFLD.

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“…Fatty liver disease is very common in certain population groups such as alcohol consumers (45%), dyslipidemic patients (50%), those who are obese (75%) and more than 95% in those who are obese alcohol consumers. [5] The standard of diagnosis in fatty liver disease is liver biopsy and histopathology. Currently specialized cross sectional imaging has become helpful in diagnosis of fatty liver albeit the need for liver biopsy.…”

Section: Discussionmentioning

confidence: 99%

Drug Induced Atypical Multifocal Variant of Fatty Liver Disease Mimicking Metastatic Liver Disease

Philips¹,

Kasana²

2017

OGH Reports

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Fatty infiltration of the liver commonly occurs in a diffuse pattern. However, in very rare presentation in the form of multiple focal lesions of the liver, mimicking metastases do occur. Accurate diagnosis is important to differentiate this condition from metastatic liver disease and hepatobiliary infections. We report a patient who consumed long term herbal remedies, presenting with multifical liver lesions that mimicked metastatic disease and in whom, specialized imaging and a needle biopsy proved the cause to be due to multifocal fatty infiltration of the liver.

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Alcoholic liver disease/nonalcoholic fatty liver disease index

Cited by 28 publications

References 37 publications

The Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) is more useful than pre-existing laboratory tests for predicting hazardous drinking: a cross-sectional study

The Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) is more useful than pre-existing laboratory tests for predicting hazardous drinking: a cross-sectional study

Relationship between Controlled Attenuation Parameter and Hepatic Steatosis as Assessed by Ultrasound in Alcoholic or Nonalcoholic Fatty Liver Disease

Drug Induced Atypical Multifocal Variant of Fatty Liver Disease Mimicking Metastatic Liver Disease

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