Alcoholic Pancreatitis: Pathogenesis, Incidence and Treatment with Special Reference to the Associated Pain

Pezzilli, Raffaele; Morselli-Labate, Antonio Maria

doi:10.3390/ijerph6112763

Cited by 13 publications

(8 citation statements)

References 84 publications

(85 reference statements)

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“…Clinically, it is characterized by recurrent attacks of abdominal or back pain, pancreatic stone deposition, exocrine and endocrine pancreatic insufficiency in advanced stages. 1,2 The endocrine dysfunction related to CP, also referred to as "pancreatogenic diabetes," is manifested as a spectrum of abnormal glucose metabolisms ranging from mild hyperglycemia to overt diabetes requiring insulin treatment. These complications of endocrine insufficiency can be more difficult to treat, partly due to an incomplete knowledge of their etiology.…”

mentioning

confidence: 99%

Rosiglitazone Inhibits Hepatic Insulin Resistance Induced by Chronic Pancreatitis and IKK-β/NF-κB Expression in Liver

Zhou

You

2014

Pancreas

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mentioning

confidence: 99%

Rosiglitazone Inhibits Hepatic Insulin Resistance Induced by Chronic Pancreatitis and IKK-β/NF-κB Expression in Liver

Zhou

You

2014

Pancreas

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“…Genetic factors may play a role in the pathogenesis of alcoholic disease. The incidence of alcoholic chronic pancreatitis appears to have decreased over the last twenty years thanks to a use [2]. In 1998, Lankisch & Banks [3] have reported that the prevalence of chronic pancreatitis in many parts of the world seemed to be in the range of 3-10 per 100,000 people [3].…”

Section: Chronic Alcoholic Pancreatitismentioning

confidence: 99%

Alcoholic Chronic Pancreatitis and Exocrine Pancreatic Insufficiency

Pezzilli¹

2017

ARGH

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The alcoholic pancreatitis continues to stimulate controversy. One of the most debated issues is whether the onset is a chronic disease or if it progresses to a chronic form after repeated episodes of acute pancreatitis and histological studies of patients with alcoholic pancreatitis have shown that the disease is chronic ab initio and that the acute alcoholic pancreatitis occurs in pancreas already damaged by chronic injury.Late manifestations are the exocrine and endocrine insufficiency and the consequence of exocrine pancreatic insufficiency is the maldigestion and malabsorption of lipids, named steatorrhea, which causes weight loss and malnutrition. The preparations of microspheres have an excellent therapeutic efficacy as demonstrated by the improvement of the lipid absorption coefficient, increase in body weight, reduction in stool frequency, stool compaction and reduction and abdominal pain due to the accelerated intestinal transit of fats undigested. The response to the treatment of pancreatic insufficiency is clinically evaluated carefully to the recovery of body weight, improvement in symptoms associated with steatorrhea and therefore the improvement of patients' quality of life. It should be kept in mind that alcoholic patients are unwilling to follow a therapy and especially to adhere to the dietary recommendations.

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“…It has been suggested that NK-1 receptor antagonists may be promising new drugs for the treatment of alcohol addiction [ 11 ]. The role played by alcohol is the cornerstone of the pathogenesis of alcoholic chronic pancreatitis [ 43 ]. The pancreatic functional changes caused by alcoholic pancreatitis progress even after the cessation of alcohol use, but the progression is slower and less severe when alcohol intake is stopped [ 44 ].…”

Section: Alcoholism Pancreatitis and The Sp/nk-1 Receptor Systemmentioning

confidence: 99%

“…In addition, protein 43, which is overexpressed in alcoholic chronic pancreatitis, stimulates the synthesis of SP, and the activation of peripheral nerve fibers also induces the synthesis/release of SP [ 43 , 46 ]. Through the NK-1 receptor, SP stimulates inflammatory cells to produce cytokines (IL-1, IL-6, IL-12, TNFα) and it increases the number of poly-morphonuclear cells, macrophages and fibroblasts.…”

Section: Alcoholism Pancreatitis and The Sp/nk-1 Receptor Systemmentioning

confidence: 99%

Targeting NK-1 Receptors to Prevent and Treat Pancreatic Cancer: a New Therapeutic Approach

Muñoz¹,

Coveñas²

2015

Cancers

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Pancreatic cancer (PC) is the fourth leading cause of cancer related-deaths in both men and women, and the 1- and 5-year relative survival rates are 25% and 6%, respectively. It is known that smoking, alcoholism and psychological stress are risk factors that can promote PC and increase PC progression. To date, the prevention of PC is crucial because there is no curative treatment. After binding to the neurokinin-1 (NK-1) receptor (a receptor coupled to the stimulatory G-protein Gαs that activates adenylate cyclase), the peptide substance P (SP)—at high concentrations—is involved in many pathophysiological functions, such as depression, smoking, alcoholism, chronic inflammation and cancer. It is known that PC cells and samples express NK-1 receptors; that the NK-1 receptor is overexpressed in PC cells in comparison with non-tumor cells, and that nanomolar concentrations of SP induce PC cell proliferation. By contrast, NK-1 receptor antagonists exert antidepressive, anxiolytic and anti-inflammatory effects and anti-alcohol addiction. These antagonists also exert an antitumor action since in vitro they inhibit PC cell proliferation (PC cells death by apoptosis), and in a xenograft PC mouse model they exert both antitumor and anti-angiogenic actions. NK-1 receptor antagonists could be used for the treatment of PC and hence the NK-1 receptor could be a new promising therapeutic target in PC.

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Alcoholic Pancreatitis: Pathogenesis, Incidence and Treatment with Special Reference to the Associated Pain

Cited by 13 publications

References 84 publications

Rosiglitazone Inhibits Hepatic Insulin Resistance Induced by Chronic Pancreatitis and IKK-β/NF-κB Expression in Liver

Rosiglitazone Inhibits Hepatic Insulin Resistance Induced by Chronic Pancreatitis and IKK-β/NF-κB Expression in Liver

Alcoholic Chronic Pancreatitis and Exocrine Pancreatic Insufficiency

Targeting NK-1 Receptors to Prevent and Treat Pancreatic Cancer: a New Therapeutic Approach

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