Alcoholism and Rapid Progression to AIDS After Seroconversion

Fong, I. W.; Read, Stanley; Wainberg, M A; Chia, Wah-Kiam; Major, Carol

doi:10.1093/clinids/19.2.337

Cited by 34 publications

(21 citation statements)

References 9 publications

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“…[32][33][34][35][36] Our study showed significantly higher levels of HIV-1 p24 in the plasma of hu-PBL-NOD/ SCID HIVE mice chronically exposed to ethanol as compared to controls fed an isocaloric diet (Table 2). Although the effects of ethanol on HIV-1 infection still remain inconclusive, our results parallel observations in which chronic alcohol exposure in macaques infected with simian immunodeficiency virus (animal model for HIV-1 infection) resulted in high plasma viral load.…”

Section: Discussionmentioning

confidence: 99%

Alcohol Abuse Enhances Neuroinflammation and Impairs Immune Responses in an Animal Model of Human Immunodeficiency Virus-1 Encephalitis

Potula

Haorah

Knipe

et al. 2006

The American Journal of Pathology

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Section: Discussionmentioning

confidence: 99%

Alcohol Abuse Enhances Neuroinflammation and Impairs Immune Responses in an Animal Model of Human Immunodeficiency Virus-1 Encephalitis

Potula

Haorah

Knipe

et al. 2006

The American Journal of Pathology

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“…Human studies, however, have yielded controversial information. During the pre-HAART era, Watson and colleagues (1994) suggested that alcohol may accelerate the development of AIDS, and case reports have confirmed these data (Fong et al, 1994). Nevertheless, a prospective study by Kaslow et al (1989) failed to demonstrate a relationship between percentage of CD4 cells, progression to AIDS, and alcohol use.…”

Section: Alcohol and Hiv/aids Disease Course Before And After The Eramentioning

confidence: 99%

Expanding Research on the Role of Alcohol Consumption and Related Risks in the Prevention and Treatment of HIV_AIDS

Bryant

2006

Substance Use & Misuse

105

110

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This article is a review of some of the major epidemiological, behavioral, biological, and integrative prevention research issues and priorities in the area of HIV/AIDS and alcohol consumption. Drinking alcohol increases both the risk for infection with HIV and related illnesses and the morbidity and mortality of patients who progress to AIDS. New and improved measurement procedures have helped in assessment of the complex patterns of alcohol use, identification of intervening explanatory mechanisms for risk behaviors and contexts, and determination of intervention outcomes. Both the direct and indirect effects of alcohol misuse appear to be major contributors to both the risk for infection with HIV and the transmission of HIV/AIDS at the individual and population levels. There is increasing evidence that perhaps no level of alcohol consumption is "safe" for those who are HIV infected and receiving antiretroviral treatment. Interdisciplinary basic behavioral and biomedical research is needed to develop comprehensive culturally appropriate strategies for programs that can be effectively delivered in community contexts in the United States and abroad and that focus on the integration of our understanding of individual behaviors, high-risk group membership, biological mechanisms, and the social and physical environments that place individuals at risk for HIV infection. High-priority topics include improving adherence to antiretroviral medications, prevention of infection in young minority women in the United States, and treatment of HIV+ pregnant women who are alcohol abusers to prevent adverse fetal outcomes, which is an international focus in under-resourced settings in Africa.

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“…With a higher density of CCR5 expressed on cell membranes, HIV would have greater opportunity to enter the cell. Beyond its effects on disease transmission, there is also evidence that alcohol allows for increased HIV replication and HIV disease progression in those already infected with HIV (Crum et al 1996;Cook et al 1997;Fong et al 1994;Bagasra et al 1993). The simplest and most obvious explanation of the behavioral link between alcohol and HIV infection is that alcohol use leads to risky sexual behaviors, although evidence of this relationship from African countries is limited.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Alcohol Consumption and Unprotected Sex Among Known HIV-discordant Couples in Rwanda and Zambia

et al. 2007

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Although alcohol abuse is highly prevalent in many countries in sub-Saharan Africa, little is known about the relationship between alcohol consumption and risky sexual behavior in these settings. An understanding of this relationship is particularly important given the high prevalence of HIV that exists in many of these countries. This study analyzes data collected from members of cohabiting HIV-discordant couples regarding alcohol consumption and self-reported condom use. After controlling for demographic and socioeconomic co-factors, alcohol use by male partners of HIV-discordant couples was associated with self-reported unprotected sex at follow-up. Counseling about alcohol use should be part of HIV testing and counseling programs, particularly among those found to be HIV-positive.

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Alcoholism and Rapid Progression to AIDS After Seroconversion

Cited by 34 publications

References 9 publications

Alcohol Abuse Enhances Neuroinflammation and Impairs Immune Responses in an Animal Model of Human Immunodeficiency Virus-1 Encephalitis

Alcohol Abuse Enhances Neuroinflammation and Impairs Immune Responses in an Animal Model of Human Immunodeficiency Virus-1 Encephalitis

Expanding Research on the Role of Alcohol Consumption and Related Risks in the Prevention and Treatment of HIV_AIDS

The Relationship Between Alcohol Consumption and Unprotected Sex Among Known HIV-discordant Couples in Rwanda and Zambia

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