Alcoholism in men patients subtyped by family history and antisocial personality.

Hesselbrock, Victor; Hesselbrock, Michie N.; Stabenau, James R.

doi:10.15288/jsa.1985.46.59

Cited by 112 publications

(41 citation statements)

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“…Prior research [8,[10][11][12] reported earlier ages at onset for first intoxications, problem drinking and development of alcohol dependence in subjects with ASPD. In these comorbid patients, the course of alcohol dependence was noted to be more severe including more alcohol-related arrests, occupational and social consequences of drinking.…”

Section: Introductionmentioning

confidence: 94%

“…Antisocial personality disorder (ASPD) is frequently associated with alcohol dependence as a comorbid condition [8,9], and is considered to be important in the pathogenesis and clinical course of alcohol dependence. Prior research [8,[10][11][12] reported earlier ages at onset for first intoxications, problem drinking and development of alcohol dependence in subjects with ASPD.…”

Section: Introductionmentioning

confidence: 99%

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Chronological Relationship between Antisocial Personality Disorder and Alcohol Dependence

2002

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Personality disorders, and particularly antisocial personality disorder (ASPD), frequently co-occur with alcohol dependence. ASPD is considered to be an important cofactor in the pathogenesis and clinical course of alcohol dependence. The chronological relationship between the onset of symptoms of ASPD and alcohol-dependence characteristics has not yet been studied in great detail and the role of ASPD in classification schemes of alcohol dependence as suggested by Cloninger and Schuckit has yet to be determined. We studied 55 alcohol-dependent patients to assess the prevalence and age at manifestation of ASPD, conduct disorder characteristics as well as alcohol dependence by employing the Semi-Structured Assessment for the Genetics of Alcoholism and the Structured Clinical Interview for DSM-III-R. Results indicate that the onset of ASPD characteristics precede that of alcohol dependence by some 4 years. This finding suggests that in patients with ASPD, alcohol dependence might be a secondary syndrome as suggested by previous research.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Chronological Relationship between Antisocial Personality Disorder and Alcohol Dependence

2002

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“…CD, especially, has long been considered a risk factor for the development of substance-use disorders (Bukstein et al, 1989;Flory and Lynam, 2003;Forrest, 1994;Harford and Muthén, 2000;Hesselbrock et al, 1985;Robins and Regier, 1991;Schuckit et al, 2008;Tarter et al, 1985). For example, increasing use of alcohol over a 6-year period was predicted by the presence of CD in a prospective study of adolescent boys by White et al (2001).…”

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confidence: 99%

Childhood ADHD and Conduct Disorder as Independent Predictors of Male Alcohol Dependence at Age 40

Knop

Penick

Nickel

et al. 2009

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: The Danish Longitudinal Study on Alcoholism was designed to identify antecedent predictors of adult male alcoholism. The infl uence of premorbid behaviors consistent with childhood conduct disorder (CD) and attention-defi cit/hyperactivity disorder (ADHD) on the development of alcohol misuse was examined. Method: Subjects were selected from a Danish birth cohort (9,125), which included 223 sons of alcoholic fathers (high risk) and 106 matched sons of nonalcoholic fathers (low risk). These subjects have been studied systematically over the past 40 years. They were evaluated in their teens (n = 238), later as adults at age 30 (n = 241), and more recently at age 40 (n = 202). At 19-year/20-year follow-ups, an ADHD scale was derived from teacher ratings and a CD scale was derived from a social worker interview. At 30-year and 40-year follow-ups, a psychiatrist used structured interviews and criteria from the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, to quantify lifetime alcoholism severity and to diagnose alcohol-use disorder. Of the original subjects, 110 had complete data for the two childhood measures and the adult alcoholism outcomes. Results: In this smaller subsample, paternal risk did not predict adult alcohol dependence. Subjects who were above a median split on both the ADHD and the CD scales were more than six times more likely to develop alcohol dependence than subjects who scored below the median on both. Although the two childhood measures were correlated, a multiple regression showed that each independently predicted a measure of lifetime alcoholism severity. Conclusions: ADHD comorbid with CD was the strongest predictor of later alcohol dependence. (J. Stud. Alcohol

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“…The concept of FHP ascribed to persons with at least one first-degree relative who is/was an alcoholic is the standard quantification of the notion concerning the familial nature of alcoholism [29][30][31][32][33][34]. FHP is seen as a reflection of the putative genetic mechanisms underlying alcoholism.…”

Section: Discussionmentioning

confidence: 99%

Use of Caffeine-Based Products and Tobacco in Relation to the Consumption of Alcohol

et al. 2003

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The relations between the intake of alcohol and that of caffeinated beverages, as well as cigarette smoking, was examined in a group of chronic alcoholics in an Israeli treatment center. When data from the total sample was analyzed, relationships between alcohol and caffeinated beverages intake and between alcohol intake and smoking were observed. Caffeine use and smoking were also related. In addition, a subgroup of subjects with a family history of alcoholism revealed correlations between alcohol and caffeine consumption, between alcohol intake and smoking, as well as caffeine use and smoking. Subjects without a family history of alcoholism also showed relationships between alcohol and caffeine use and smoking. However, coffee intake and tobacco use was not related in this subgroup. The relevance of the findings to previous reports concerning alcohol drinking and smoking as well as the intake of coffee appear to be consistent with a notion of interaction between these respective behaviors occurring at a behavioral level rather than a genetic one.

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Alcoholism in men patients subtyped by family history and antisocial personality.

Cited by 112 publications

References 0 publications

Chronological Relationship between Antisocial Personality Disorder and Alcohol Dependence

Chronological Relationship between Antisocial Personality Disorder and Alcohol Dependence

Childhood ADHD and Conduct Disorder as Independent Predictors of Male Alcohol Dependence at Age 40

Use of Caffeine-Based Products and Tobacco in Relation to the Consumption of Alcohol

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