Alcoholism, peripheral neuropathy (PNP) and cardiovascular autonomic neuropathy (CAN)

Agelink, M.W.; Maleßa, R.; Weisser, U; Lemmer, W.; Zeit, T.; Majewski, T.; Klieser, E.

doi:10.1016/s0022-510x(98)00266-4

Cited by 46 publications

(51 citation statements)

References 37 publications

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“…In addition, no significant statistical correlation was found between indices of somatic and autonomic neuropathy. Our findings do not support the existence of a parallel involvement of peripheral somatic and autonomic cardiovascular nerve fibers in chronic alcoholism [6,7]. The present data are in accordance with recent papers about other metabolic disturbances, such as uremia and diabetes.…”

Section: Discussionsupporting

confidence: 57%

“…Different results described by previous papers showing a correlation between somatic and autonomic dysfunction in alcoholics can be explained by (a) difference in inclusion criteria, 17% and 25% of patients recruited by Monforte et al [6] also had, respectively, liver or pancreatic diseases, which are well known to cause ANS derangement [24,25]; (b) different methods for evaluating somatic dysfunction, Agelink et al [7] used a score based only on clinical data without electrophysiological investigation. Furthermore, the assessment of a correlation between somatic and autonomic neuropathy was based on single parameters, such as sensory and motor action potential amplitudes related to heart rate variability [6].…”

Section: Discussionmentioning

confidence: 91%

“…Two recent studies reported that autonomic neuropathy is exhibited by approximately a quarter of chronic alcoholics and by more than one third of patients with somatic neuropathy [6,7]. A significant comorbidity of the two disorders was found with a more frequent involvement of parasympathetic pathways than sympathetic ones.…”

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics?

Nicolosi

Leo

Girlanda

et al. 2005

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 91%

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Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics?

Nicolosi

Leo

Girlanda

et al. 2005

Journal of the Neurological Sciences

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“…All 10 studies of HRV in alcohol-dependent subjects without withdrawal used a casecontrol design in comparing alcohol-dependent subjects with nonalcoholic controls. They are only grossly comparable, however, since only 5 of 10 studies indicated that alcohol dependence was defined according to DSM-III R criteria (Agelink et al, 1998;DePetrillo et al, 1999;Karimullah et al, 2001;Rechlin et al, 1996) or DSM-IV criteria (Irwin et al, 2006). Six of 10 studies reported an average drinking length (between 3 and 40 years) and average daily alcohol consumption (100 to 350 g/d; Agelink et al, 1998;Irwin et al, 2006;Karimullah et al, 2001;Malpas et al, 1991;Weise et al, 1985Weise et al, , 1986.…”

Section: Studies Of Hrv In Alcohol-dependent Subjectsmentioning

confidence: 99%

Characteristics of Heart Rate Variability in Alcohol-Dependent Subjects and Nondependent Chronic Alcohol Users

Karpyak

Romanowicz

Schmidt

et al. 2013

Alcohol Clin Exp Res

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Heart rate variability (HRV) is an objective and sensitive measure of integrated physiological functioning reflective of heart rhythm responsivity to internal and external demands. Reduced HRV is associated with vulnerability to stress and deterioration of medical and/or psychiatric conditions, while increased HRV is associated with a favorable treatment response and recovery from various medical and/or psychiatric conditions. Our previous review found that acute alcohol consumption caused decreased parasympathetic and increased sympathetic HRV effects in both nonalcoholic and chronic alcohol users. This review investigates the effects of chronic alcohol consumption on HRV in alcohol-dependent subjects and nondependent users. MEDLINE, Scopus, and PubMed were searched for human experimental and clinical trials that measured the effects of chronic alcohol use on HRV. Only publications that included a description of their study designs and clearly stated methodologies for data collections, and outcome measures were reviewed. We have reviewed a total of 24 articles. In nondependent users, low dose (approximating the recommended daily amount of 1 standard drink in women and 2 in men) use is associated with increased HRV parameters compared to those who drink less frequently or abstain altogether. A further increase in consumption is associated with decreased HRV compared to both abstainers and more moderate drinkers. HRV changes during withdrawal generally follow the same negative direction but are more complex and less understood. In dependent subjects, an improvement in HRV was seen following abstinence but remained reduced compared to nonalcoholic controls. This review demonstrates that HRV changes associated with chronic use follow a J-shaped curve. It supports recommendations that limit daily alcohol intake to no more than 2 drinks for men and 1 drink for women. Future studies should investigate HRV as a biomarker of alcoholism development and treatment response as well as the physiological basis for alcohol effects on HRV.

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“…The resulting changes in HR, the breath-dependent amplitudes of the R-R deflections, and properly recognized QRS complexes were also registered. The coefficient of variation during deep breathing (CVd) and the root mean square of successive differences during deep breathing (RMSSDd) were calculated from at least 100 artifact-flee R-R intervals [8,46]. During the breathing cycle with the maximum HRV, the longest R-R interval during expiration (E) and the shortest R-R interval during inspiration (I) were determined to obtain the expiratory-inspiratory (E/I) ratio and the E-I difference.…”

Section: Deep-breathing Testmentioning

confidence: 99%

Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate

Agelink

Maleßa

Baumann

et al. 2001

Clinical Autonomic Research

299

185

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The authors undertook this study to determine the effects of age, gender, and heart rate (HR) on the results of cardiac autonomic function tests for measuring heart rate variability (HRV) in a large sample of healthy subjects (n = 309). Conventional tests (deep breathing, maximum/minimum 30:15 ratio), and a standardized 5-minute resting study, including spectral analysis of HR, were used. The main findings included (1) the indices of all tests, except for the ratio of the low- (LF) to high-frequency (HF) spectral power (LF/HF ratio) and HR itself, are inversely related to age in both sexes; (2) the 5-minute spectral bands (except for the LF/HF ratio), the variation coefficient, expiratory-inspiratory ratio during deep breathing, and the maximum/minimum 30:15 ratio are independent of HR; (3) women up to the age of 55 years have a higher resting HR compared with men; (4) young and middle-aged women show a significantly lower LF power and LF/HF ratio compared with age-matched men, whereas no significant gender differences are observed in the absolute HF power. The authors computed age- and gender-dependent normal values for each of the HRV indices studied here and discuss the clinical consequences arising from gender differences in HRV.

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Alcoholism, peripheral neuropathy (PNP) and cardiovascular autonomic neuropathy (CAN)

Cited by 46 publications

References 37 publications

Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics?

Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics?

Characteristics of Heart Rate Variability in Alcohol-Dependent Subjects and Nondependent Chronic Alcohol Users

Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate

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