Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer

Chen, Ying; Orlicky, David J.; Matsumoto, Akiko; Singh, Surendra; Thompson, David C.; Vasiliou, Vasilis

doi:10.1016/j.bbrc.2011.01.002

Cited by 97 publications

(98 citation statements)

References 22 publications

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“…SKNAS iCSCs expressed elevated levels of genes involved in stem cell pathways (NOTCH/DELTA, BMPR/BMP, and FZD/WNT) and genes highly expressed in other CSC types. These include ALDH1B1 (colon carcinoma (20); BIN1, COL1A1, COL1A2, ENPP2, and THY1 (breast CSC-like cells (21); and PDPN (glioblastoma sphere cultures) (22) (Fig. S5 A and B).…”

Section: Short-term Treatments With Epigenetic Modifiers Enhance the mentioning

confidence: 99%

Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas

Ikegaki

Shimada

Fox

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Cancer stem cells (CSCs) are plastic in nature, a characteristic that hampers cancer therapeutics. Neuroblastoma (NB) is a pediatric tumor of neural crest origin, and half of the cases are highly aggressive. By treating NB cell lines [SKNAS, SKNBE(2)C, CHP134, and SY5Y] with epigenetic modifiers for a short time, followed by sphere-forming culture conditions, we have established stem cell-like NB cells that are phenotypically stable for more than a year. These cells are characterized by their high expression of stemness factors, stem cell markers, and open chromatin structure. We referred to these cells as induced CSCs (iCSCs). SKNAS iCSC and SKNBE(2)C iCSC clones (as few as 100 cells) injected s.c. into SCID/Beige mice formed tumors, and in one case, SKNBE(2)C iCSCs metastasized to the adrenal gland, suggesting their increased metastatic potential. SKNAS iCSC xenografts showed the histologic appearance of totally undifferentiated large-cell NBs (LCNs), the most aggressive and deadly form of NB in humans. Immunohistochemical analyses showed that SKNAS iCSC xenografts expressed high levels of the stem cell marker CXCR4, whereas the SKNAS monolayer cell xenografts did not. The patterns of CXCR4 and MYC expression in SKNAS iCSC xenografts resembled those in the LCNs. The xenografts established from the NB iCSCs shared two common features: the LCN phenotype and high-level MYC/MYCN expression. These observations suggest both that NB cells with large and vesicular nuclei, representing their open chromatin structure, are indicative of stem cell-like tumor cells and that epigenetic changes may have contributed to the development of these most malignant NB cells.tumor initiating cells | prominent nucleoli N euroblastoma (NB) is the most common extracranial pediatric malignancy. Although some NBs are easily treatable, nearly 50% of the tumors exhibit aggressive behavior. The International Neuroblastoma Risk Group Classification is used to classify NB at diagnosis (1). High-risk NBs are associated with older age, advanced stages, unfavorable histologic features, widespread tumor dissemination, and poor long-term survival (1). Current treatment for these NBs includes high-dose chemotherapy or myeloablative cytotoxic therapy with autologous hematopoietic stem cell transplantation (2). However, late relapse is often seen despite achieving complete clinical remission. A subset of high-risk NBs, which is refractory to current frontline therapy designed for high-risk NB, is termed ultra-high-risk NB (3, 4).NB is histopathologically defined as neuroblastic tumors with less than 50% Schwannian stromal components. On the basis of the degree of neuronal differentiation, NB is further divided into undifferentiated (UD), poorly differentiated, and differentiating subtypes (5, 6). A unique histological subset of NBs within the UD and poorly differentiated subtypes has also been identified (7,8). These tumors are uniformly composed of large cells with sharply outlined nuclear membranes and one to four prominent nucleoli and are referred...

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Section: Short-term Treatments With Epigenetic Modifiers Enhance the mentioning

confidence: 99%

Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas

Ikegaki

Shimada

Fox

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…Studies showed that ALDH1B1 and ALDH1A1 are differentially expressed in normal human tissues, but ALDH1B1 is expressed at higher levels than ALDH1A1 in human epithelial cancers. ALDH1B1 was abundantly expressed in adenocarcinomas originating from the tissue and particularly in colonic adenocarcinoma (Chen, et al, 2011). Thus it can be deduced that ALDH1B1 may be a marker for colon cancer diagnosis.…”

Section: Colon Cancermentioning

confidence: 98%

“…ALDH1B1 is expressed at higher levels than ALDH1A1 in human epithelial cancers. ALDH1B1 was abundantly expressed in adenocarcinomas originating from the tissue and particularly in colonic adenocarcinoma (Chen, et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Aldehyde Dehydrogenase: Cancer and Stem Cells

Allahverdiyev¹,

Bağırova²,

Oztel³

et al. 2012

Dehydrogenases

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“…Human ALDH1B1 has an exclusive preference for NAD+ as a cofactor and is catalytically active toward short-and medium-chain aliphatic aldehyde, the product of lipid peroxidation and aromatic aldehyde [26]. For SNP (rs250619092) in DLY pigs, the genotype CC had a higher frequency (CC 79.1%>CA 20.8%), but the individuals with the CA genotype showed a larger daily weight gain (CC 953.07±18.37<CA 1061.46±34.89, P = 0.0059).…”

Section: Growth Traits Sucla2(c/t) Suclg2(c/t) Aldh1b1(c/a)mentioning

confidence: 99%

“…However, our genes of interest have a common function and are involved in certain metabolic diseases [26,[28][29][30], which suggest that functions within chemical and energy metabolism may account for the effects of these genes on growth.…”

Section: Growth Traits Sucla2(c/t) Suclg2(c/t) Aldh1b1(c/a)mentioning

confidence: 99%

Associations between gene polymorphisms in two crucial metabolic pathways and growth traits in pigs

Yang

Wang

et al. 2012

Chin. Sci. Bull.

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Propanoate metabolism and fatty acid metabolism are crucial metabolic pathways in vivo that have been studied extensively and have shown a significant influence on the growth and diseases of animals. In order to identify the essential genes significantly associated with porcine growth traits at the pathway level, we selected 14 candidate genes with 58 SNPs, including 24 tag SNPs and 34 predicted SNPs, in the two essential pathways to test using the SNaPshot mini-sequencing method. Association analysis was performed using both static and dynamic phenotypic records. The results showed that four SNPs, respectively in SUCLA2, SUCLG2, ACADS, and ALDH1B1, were significantly associated with growth in pigs. In addition, an exciting finding was that the change of transcription factor binding site that resulted from alteration of the bases in SUCLG2 brought out a transcription factor binding site for POU1F1a, which is the product of a notable marker gene for growth of animals. Growth traits, including total feed intake, daily feed intake, feed conversion ratio and daily weight gain, have a direct impact on production efficiency in the swine industry. Studies on the relationship between noted growth-related genes and growth traits have attracted a great deal of attention for decades. Unfortunately, despite the fact that numerous studies have been performed, few of them have demonstrated the nature and mechanism of genetic variation that underlies the quantitative traits. The methods for studying quantitative traits should be reconsidered, because the use of only SNPs as the basic units of association analysis has shown several limitations. The functions of SNPs and genes are usually carried out through intricate pathways of reactions and interactions [1]. Therefore, studies based on the candidate pathways approach may not only provide us with the possibility to gain more extensive insight into the functional basis of association but also facilitate and unravel the detailed genetic control mechanisms of complex phenotypes. Previous study in our laboratory has shown that the propanoate and fatty acid metabolic pathways exhibit significant down-regulation under PPARα knockout conditions in the livers of mice, which was detected by the analysis of mouse PPARα dependent or independent datasets by GSEA (Gene Set Enrichment Analysis) [2]. The propanoate and fatty acid metabolic processes are crucial metabolic pathways in vivo, and may be connected with the TCA (tricarboxylic acid cycle) cycle. Metabolism of fatty acids is essential for the organism because they are a major source of energy and the structural components of membranes. In addition, a variety of fatty acids perform key biological functions such as the regulation of lipid metabolism, cell division and inflammation [3][4][5]. The metabolism of propanoate (propionic acid) begins with its conversion to propionyl coenzyme A (propionyl-CoA), which is usually the first step in the metabolism of carboxylic acids. The regulatory mechanisms of the propanoate and fatty acid met...

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Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer

Cited by 97 publications

References 22 publications

Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas

Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas

Aldehyde Dehydrogenase: Cancer and Stem Cells

Associations between gene polymorphisms in two crucial metabolic pathways and growth traits in pigs

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