ALDH1 in Combination with CD44 as Putative Cancer Stem Cell Markers are Correlated with Poor Prognosis in Urothelial Carcinoma of the Urinary Bladder

Keymoosi, Hossein; Gheytanchi, Elmira; Asgari, Mojgan; Shariftabrizi, Ahmad; Madjd, Zahra

doi:10.7314/apjcp.2014.15.5.2013

Cited by 55 publications

(38 citation statements)

References 63 publications

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“…The positive population of these cells was also found to over express certain stemness markers like Bmi1 that maintains the undifferentiated state of the cell (Prince et al, 2007). CD44 expression individually negatively correlated with poor 5 year survival while its high levels along with ALDH and phosphorylated STAT3 correlated with high-grade of HNSCC which is consistent with the previous findings in urothelial carcinoma (Chen et al, 2010;Keymoosi et al, 2014).…”

Section: Cd44supporting

confidence: 87%

See 1 more Smart Citation

Cancer Stem Cells and Stemness Markers in Oral Squamous Cell Carcinomas

Patel¹,

Shah²,

Shah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Cd44supporting

confidence: 87%

“…Inspite of this, we cannot refute that CD44 either alone or in combination can be considered to have the properties of a cancer stem cell marker and being a tumour initiator in OSCC but its role and consistency needs to be validated Keymoosi et al, 2014).…”

Section: Cd44mentioning

confidence: 93%

Cancer Stem Cells and Stemness Markers in Oral Squamous Cell Carcinomas

Patel¹,

Shah²,

Shah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…CSCs are considered to possess resistance to chemotherapy, and there is a direct link between the expression of CSC markers and patient survival (5,20). The abnormal detection of CSC markers in primary or recurrent lesions prior and subsequent to chemotherapy may partly explain the high rate of metastatic recurrences and short survival, which is clearly reflected in this case.…”

Section: Discussionmentioning

confidence: 84%

“…Cancer stem-like cells (CSCs) are a small population of cancer cells that have the properties of tumor-initiating ability, self-renewal and differentiation (4). CSCs are more resistant to chemotherapy and radiotherapy than non-CSC populations via various mechanisms (5). Several studies have indicated that detection of CSC markers such as cluster of differentiation 44 (CD44) and aldehyde dehydrogenase 1 A1 (ALDH1A1) in urologic neoplasms can provide useful prognostic information (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis

Lü

Zhuang

2017

Oncology Letters

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Abstract. The simultaneous occurrence of renal cell carcinoma (RCC) and urothelial carcinoma (UC) in the same kidney is extraordinarily rare, and is also known as multiple primary malignant tumors. The present study reports the case of a 76-year-old female with synchronous ipsilateral RCC and UC of the renal pelvis, who underwent operation, chemotherapy and reoperation when recurrence of RCC or UC was identified. Cluster of differentiation 44 (CD44) is one of the promising markers for identifying cancer stem cells in various solid tumors, along with aldehyde dehydrogenase 1 A1 (ALDH1A1). Detection of CD44 and ALDH1A1 prior to and subsequent to chemotherapy could provide useful prognostic information. New treatments against the cancer stem cells fraction should be used in combination with chemotherapy to improve the outcome for patients with overexpression of CSC markers. IntroductionCombined renal cell carcinoma (RCC) and urothelial carcinoma (UC) of the renal pelvis is a rare type of multiple primary malignant tumor, which is characterized by the coexistence of two histologically distinct malignant tumors in the same organ with a shorter median time to relapse and mortality compared with a solitary tumor (1). There are only a few such cases in the world (2,3). Research into prognostic markers of multiple primary malignant tumors is important to establish adequate therapeutic strategies. Cancer stem-like cells (CSCs) are a small population of cancer cells that have the properties of tumor-initiating ability, self-renewal and differentiation (4). CSCs are more resistant to chemotherapy and radiotherapy than non-CSC populations via various mechanisms (5). Several studies have indicated that detection of CSC markers such as cluster of differentiation 44 (CD44) and aldehyde dehydrogenase 1 A1 (ALDH1A1) in urologic neoplasms can provide useful prognostic information (6-8). Furthermore, CD44 and ALDH1A1 have demonstrated high levels of activity in several types of solid cancer (9).The present study reports a case of synchronous RCC and UC of the left kidney with poor prognosis. Abnormal expression of CD44 and ALDH1A1 CSC markers investigated prior to and subsequent to chemotherapy may indicate poor prognosis. Materials and methods Patient.A 76-year-old female with a 5-month history of left flank pain presented to the Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School (Nanjing, China) without a history of fever, fatigue, weight loss or gross hematuria in March 2014. Her medical history included an 8-year history of hypertension, and there was no family history of urologic malignancies. Physical examination revealed that her vital signs were stable, and no palpable abdominal mass could be detected. Results from routine examinations, including electrocardiogram, chest radiography, pulmonary function test and laboratory tests of blood and urine, were all within the normal limits, with the exception of 8.4 red blood cells (RBC)/µl in urine (normal range, 0-5 RBC...

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“…The CSCs have been identified in several solid tumors based on expression of certain CSC surface markers. Until now, CSCs have been defined by such cell surface markers as CD24, CD29, CD34, CD44, CD90, CD133, aldehyde dehydrogenase-1 (ALDH-1) and epithelialspecific antigen (ESA) (Keymoosi, et al, 2014;Sabet, et al, 2014) (Table 1).…”

Section: Cancer Stem Cellsmentioning

confidence: 99%

Emerging Roles of Krüppel-Like Factor 4 in Cancer and Cancer Stem Cells

Ding¹,

Liu²,

Li³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Cancer stem cells (CSCs) are rare subpopulations within tumors which are recognized as culprits in cancer recurrence, drug resistance and metastasis. However, the molecular mechanisms of how CSCs are regulated remain elusive. Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverse functions in cell differentiation, proliferation, embryogenesis and pluripotency. Recent progress has highlighted the significance of KLFs, especially KLF4, in cancer and CSCs. Therefore, for better therapeutics of cancer disease, it is crucial to develop a deeper understanding of the mechanisms of how KLF4 regulate CSC functions. Herein we summarized the current understanding of the transcriptional regulation of KLF4 in CSCs, and discussed the functional implications of targeting CSCs for potential cancer therapeutics.

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ALDH1 in Combination with CD44 as Putative Cancer Stem Cell Markers are Correlated with Poor Prognosis in Urothelial Carcinoma of the Urinary Bladder

Cited by 55 publications

References 63 publications

Cancer Stem Cells and Stemness Markers in Oral Squamous Cell Carcinomas

Cancer Stem Cells and Stemness Markers in Oral Squamous Cell Carcinomas

Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis

Emerging Roles of Krüppel-Like Factor 4 in Cancer and Cancer Stem Cells

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