Aldioxa improves delayed gastric emptying and impaired gastric compliance, pathophysiologic mechanisms of functional dyspepsia

Asano, Teita; Aida, Shuji; Suemasu, Shintaro; Tahara, Kayoko; Tanaka, Ken Ichiro; Mizushima, Tohru

doi:10.1038/srep17519

Cited by 18 publications

(20 citation statements)

References 36 publications

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“…4A, increased balloon pressure resulted in an increase in balloon volume. The pre-administration of acotiamide potentiated this increase, as described previously [14], indicating that acotiamide stimulates gastric accommodation. Similarly, pre-administration of anethole potentiated gastric accommodation (Fig.…”

Section: -11 -supporting

confidence: 86%

“…was also monitored by use of the phenol red method as previously described [14]. Mice were fasted for 18 h and had free access to water, following which 1.5% carboxymethylcellulose sodium salt containing 0.05% phenol red (0.5 ml/mouse) was -6 -intragastrically administered.…”

Section: Measurement Of Gastric Emptying With the Phenol Red Method mentioning

confidence: 99%

“…Gastric content collected and centrifuged at 3,000 rpm for 15 min after treatment with 10 ml of 0.1 M NaHCO3. The amount of phenol red in the supernatant was determined based on the absorbance at 558 nm measured using a microplate reader (Multiscan GO, Thermo Scientific, Yokohama, Japan) as described previously [14]. In any of these animal models, anethole (in 0.06% Tween-80) or other drugs (in 1% methylcellulose) was administered intragastrically at 10 mL/kg 1 h before the administration of phenol red.…”

Section: Measurement Of Gastric Emptying With the Phenol Red Method mentioning

confidence: 99%

“…We recently screened for clinically used drugs with the ability to improve delayed gastric emptying in rats and identified aldioxa [14]. This screening procedure also identified anethole (1-methoxy-4-((E)-propenyl)-benzene), a major component of essential oils of anise and fennel and has been used in flavoring, alcoholic beverage production and pharmaceutical formulations for many years [15].…”

Section: Introductionmentioning

confidence: 99%

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Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents

Asano

Aida

Suemasu

et al. 2016

Biochemical and Biophysical Research Communications

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Functional dyspepsia (FD), a functional gastrointestinal disorder, is characterized by persistent or recurrent postprandial upper abdominal discomfort and epigastric pain. The high prevalence of FD and associated healthcare costs suggests that treatment of this condition by methods other than prescribed medicines, such as natural products, could be beneficial. Delayed gastric emptying and impaired gastric accommodation play important roles in the development of FD. Anethole (1-methoxy-4-((E)-propenyl)-benzene), a major component of essential fennel oil, has been used as a flavoring, in alcoholic beverage production and in pharmaceutical formulations for many years. In this study, we examined the effects of anethole on delayed gastric emptying and impaired gastric accommodation in rodents. Oral administration of anethole improved clonidine-induced delayed gastric emptying but did not affect normal gastric emptying in mice. Fennel oil and Anchu-san (a Japanese herbal medicine containing anethole) also restored delayed gastric emptying. Furthermore, oral administration of anethole stimulated gastric accommodation in rats. These results suggest that anethole could be beneficial for the treatment of FD.

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Section: -11 -supporting

confidence: 86%

Section: Measurement Of Gastric Emptying With the Phenol Red Method mentioning

confidence: 99%

Section: Measurement Of Gastric Emptying With the Phenol Red Method mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents

Asano

Aida

Suemasu

et al. 2016

Biochemical and Biophysical Research Communications

Self Cite

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“…Functional dyspepsia (FD) is a non-organic gastrointestinal (GI) disorder with persistent or recurrent sensations of early satiety, post-prandial fullness, nausea, and pain or discomfort in the upper abdomen ( 1 , 2 ). According to recent statistics, FD affects 5–11% of the population worldwide ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Weikangning therapy in functional dyspepsia and the protective role of Nrf2

Chang

Wei

et al. 2017

Experimental and Therapeutic Medicine

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Functional dyspepsia (FD) is a non-organic gastrointestinal disorder that has a marked negative impact on quality of life. Compared with conventional pharmacological therapies, the traditional Chinese medicine weikangning (WKN) is a safe and effective treatment for FD. The present study aimed to determine the molecular mechanisms underlying the efficacy of WKN. The effect of different concentrations of WKN on the proliferation of the human gastric mucosal epithelial cell line GES-1 was assessed. The optimal WKN concentration to promote cell proliferation was determined, and this concentration was used to examine the effect of WKN compared with a domperidone-treated positive control group on the antioxidant capacity of GES-1 cells. The effect of WKN treatment on the growth and antioxidant activity of GES-1 cells was also assessed following nuclear factor erythroid 2 like 2 (Nrf2) knockdown. The optimal WKN dose for promoting cell growth was determined to be 0.025 mg/ml; at this concentration the expression of the antioxidant proteins glutathione S-transferase P and superoxide dismutase 2 (SOD2) were significantly elevated (P<0.0001). Furthermore, the amount of reduced glutathione and activity of SOD2 were significantly increased (P<0.0001 and P<0.01, respectively), and malondialdehyde content was significantly decreased, compared with the controls (P<0.001). With WKN treatment, the transcription of Nrf2 and its downstream genes were significantly upregulated (P<0.01), and the level and nuclear distribution of Nrf2 protein was also markedly increased. Following Nrf2 silencing, the protective antioxidant effects of WKN treatment were impaired and GES-1 cell proliferation decreased. The results of the present study suggest that the efficacy of WKN in protecting gastric mucosal epithelial cells in FD is antioxidant-dependent and mediated by Nrf2 activation.

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