2011
DOI: 10.1194/jlr.m015859
|View full text |Cite
|
Sign up to set email alerts
|

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
43
0

Year Published

2012
2012
2019
2019

Publication Types

Select...
6
1
1

Relationship

3
5

Authors

Journals

citations
Cited by 41 publications
(43 citation statements)
references
References 35 publications
0
43
0
Order By: Relevance
“…HepG2 cells were cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum (FBS). Transient transfections were performed in triplicate, as previously described . Detailed information can be found in http://onlinelibrary.wiley.com/doi/10.1002/hep.28472/suppinfo.…”
Section: Methodsmentioning
confidence: 99%
“…HepG2 cells were cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum (FBS). Transient transfections were performed in triplicate, as previously described . Detailed information can be found in http://onlinelibrary.wiley.com/doi/10.1002/hep.28472/suppinfo.…”
Section: Methodsmentioning
confidence: 99%
“…It has recently been reported that hepatic overexpression of a novel FXR target, aldo-keto reductase 1B7 ( Akr1b7 ), a gene previously linked to detoxification, lowered plasma glucose levels and reduced expression of both gluconeogenic enzymes and lipogenic enzymes 86,88 . Thus, it is possible that AKR1B7 is responsible for mediating at least some of the effects observed with FXR activation.…”
Section: Farnesoid X Receptormentioning
confidence: 99%
“…Originally suggested to be involved in lipid peroxidation, AKR1B7 was found to be a direct target of FXR in both the liver and intestine. Adenovirus-mediated overexpression of AKR1B7 in db/db mice ameliorated hepatic steatosis [34]. …”
Section: Role Of Fxr In Lipid and Glucose Metabolism And Inflammationmentioning
confidence: 99%
“…The FXR-SHP-SREBP-1c pathway does not appear to play a role in this process [25, 2932]. Instead, other genes/pathways, including FGF21 [43], ChREBP [33], PPARα [36, 41], and AKR1B7 [34] may play a role in FXR-mediated reduction in hepatic triglyceride levels. Activation of FXR regulates plasma cholesterol and triglyceride levels through modulating several genes, including SR-BI [19], LDLR [16], Syndecan-1[39], VLDLR [38], ApoCII, ApoCIII [37] and ANGPTL3 [25].…”
Section: Figurementioning
confidence: 99%