Aldo-keto reductases: Role in cancer development and theranostics
SIDDAVARAM NAGINI,
PRATHAP REDDY KALLAMADI,
KRANTHI KIRAN KISHORE TANAGALA
et al.
Abstract:Aldo-keto reductases (AKRs) are a superfamily of enzymes that play crucial roles in various cellular processes, including the metabolism of xenobiotics, steroids, and carbohydrates. A growing body of evidence has unveiled the involvement of AKRs in the development and progression of various cancers. AKRs are aberrantly expressed in a wide range of malignant tumors. Dysregulated expression of AKRs enables the acquisition of hallmark traits of cancer by activating oncogenic signaling pathways and contributing to… Show more
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