ALDOC regulated the biological function and immune infiltration of gastric cancer cells

Chen, Liqiao; Zeng, Yi Xin; Ren, Baoqing; Wang, Xinyu; Zhao, F-J.; Du, Jitao; Zhang, Rupeng; Deng, Jingyu

doi:10.1016/j.biocel.2023.106407

Cited by 4 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In several tumor types, ALDOC expression is related to poor clinical outcome [ 48 ]. Furthermore, ALDOC is significantly correlated with immune infiltration in gastric cancer by influencing macrophage differentiation [ 49 ]. LTA4H is involved in the metabolism of leukotrienes, converting them into biologically active leukotriene B4, which possesses functions in inflammation mediation and immune regulation [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

An immune-related exosome signature predicts the prognosis and immunotherapy response in ovarian cancer

Zhu,

Ma,

Tian

et al. 2024

BMC Women's Health

View full text Add to dashboard Cite

Background Cancer-derived exosomes contribute significantly in intracellular communication, particularly during tumorigenesis. Here, we aimed to identify two immune-related ovarian cancer-derived exosomes (IOCEs) subgroups in ovarian cancer (OC) and establish a prognostic model for OC patients based on immune-related IOCEs. Methods The Cancer Genome Atlas (TCGA) database was used to obtain RNA-seq data, as well as clinical and prognostic information. Consensus clustering analysis was performed to identify two IOCEs-associated subgroups. Kaplan-Meier analysis was used to compare the overall survival (OS) between IOCEs-high and IOCEs-low subtype. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to investigate the mechanisms and biological effects of differentially expressed genes (DEGs) between the two subtypes. Besides, an IOCE-related prognostic model of OC was constructed by Lasso regression analysis, and the signature was validated using GSE140082 as the validation set. Results In total, we obtained 21 differentially expressed IOCEs in OC, and identified two IOCE-associated subgroups by consensus clustering. IOCE-low subgroup showed a favorable prognosis while IOCE-high subgroup had a higher level of immune cell infiltration and immune response. GSEA showed that pathways in cancer and immune response were mainly enriched in IOCE-high subgroup. Thus, IOCE-high subgroup may benefit more in immunotherapy treatment. In addition, we constructed a risk model based on nine IOCE-associated genes (CLDN4, AKT2, CSPG5, ALDOC, LTA4H, PSMA2, PSMA5, TCIRG1, ANO6). Conclusion We developed a novel stratification system for OV based on IOCE signature, which could be used to estimate the prognosis as well as immunotherapy for OC patient.

show abstract

Section: Discussionmentioning

confidence: 99%

An immune-related exosome signature predicts the prognosis and immunotherapy response in ovarian cancer

Zhu,

Ma,

Tian

et al. 2024

BMC Women's Health

View full text Add to dashboard Cite

show abstract

“…Moreover, overexpressed MAT2A elevated the expression of RIP1 by increasing the H3K4 methylation at its promoter regions to induce the polarisation of M2 TAMs 47 . Several studies have demonstrated that the high expression of TUBA1A, ELK3, GKN2, COL1A2, RAI14, KIF23, GHRL, KCND2, SERPINE1, COL5A2, ALDOC and SLC38A2 and low expression of CD155 and AKR1B10 in GC indicate higher M2 TAM infiltration in the TME using data from public databases 93–107 . Furthermore, TAMs elevated the expression of PI3K‐γ by increasing the uptake of extracellular lipids, thereby inducing M2 phenotype polarisation 44 .…”

Section: The Role and Mechanism Of Tams In Gcmentioning

confidence: 99%

“… 47 Several studies have demonstrated that the high expression of TUBA1A, ELK3, GKN2, COL1A2, RAI14, KIF23, GHRL, KCND2, SERPINE1, COL5A2, ALDOC and SLC38A2 and low expression of CD155 and AKR1B10 in GC indicate higher M2 TAM infiltration in the TME using data from public databases. 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 Furthermore, TAMs elevated the expression of PI3K‐γ by increasing the uptake of extracellular lipids, thereby inducing M2 phenotype polarisation. 44 GC cells are characterised by enhanced glycolysis, producing large amounts of lactic acid that can induce the polarisation of M2 TAMs by activating the monocarboxylate channel transporter‐hypoxia inducible factor 1 subunit alpha (MCT–HIF1α) axis in macrophages.…”

Section: The Role and Mechanism Of Tams In Gcmentioning

confidence: 99%

Tumour‐associated macrophages in gastric cancer: From function and mechanism to application

Li,

Sun,

Zeng

et al. 2023

Clinical & Translational Med

View full text Add to dashboard Cite

BackgroundGastric cancer (GC) is a malignant tumour, with high morbidity and mortality rates worldwide. The occurrence and development of GC is a complex process involving genetic changes in tumour cells and the influence of the surrounding tumour microenvironment (TME). Accumulative evidence shows that tumour‐associated macrophages (TAMs) play a vital role in GC, acting as plentiful and active infiltrating inflammatory cells in the TME.Main bodyIn this review, the different functions and mechanisms of TAMs in GC progression, including the conversion of phenotypic subtypes; promotion of tumour proliferation, invasion and migration; induction of chemoresistance; promotion of angiogenesis; modulation of immunosuppression; reprogramming of metabolism; and interaction with the microbial community are summarised. Although the role of TAMs in GC remains controversial in clinical settings, clarifying their significance in the treatment selection and prognostic prediction of GC could support optimising TAM‐centred clinicaltherapy.ConclusionIn summary, we reviewed the the phenotypic polarisation, function and molecular mechanism of TAMs and their potential applications in the treatment selection and prognostic prediction of GC.

show abstract

Fructose-bisphosphate Aldolase C Expression is Associated with Poor Prognosis and Stemness in Gastric Cancer

Ishikawa,

Shiwa,

Katsuya

et al. 2024

Acta Histochem. Cytochem.

View full text Add to dashboard Cite

ALDOC regulated the biological function and immune infiltration of gastric cancer cells

Cited by 4 publications

References 30 publications

An immune-related exosome signature predicts the prognosis and immunotherapy response in ovarian cancer

An immune-related exosome signature predicts the prognosis and immunotherapy response in ovarian cancer

Tumour‐associated macrophages in gastric cancer: From function and mechanism to application

Fructose-bisphosphate Aldolase C Expression is Associated with Poor Prognosis and Stemness in Gastric Cancer

Contact Info

Product

Resources

About