Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation

Zhou, Junying; Lei, Ningjing; Qin, Bo; Chen, Mengyu; Gong, Shuai; Sun, Hao; Qiu, Luojie; Wu, Fengling; Guo, Ruixia; Ma, Qian; Li, Yong; Chang, Lei

doi:10.1080/15384047.2023.2287128

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Aldolase A (ALDOA), a member of the ALDO family, plays an important role in cellular glycolysis and the maintenance of glucose homeostasis [ 27 ]. A recent study showed that knockdown of ALDOA blocked cervical cancer cells at G2/M stage and inhibited the proliferation of tumor cells [ 28 ]. These results implied that it was possible to block tumor progression by targeting ALDOA for the purpose of tumor treatment.…”

Section: The Regulatory Role Of Glycolysis In Tumor Developmentmentioning

confidence: 99%

The regulatory roles and clinical significance of glycolysis in tumor

Qiao,

Hu,

Wang

2024

Cancer Communications

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Metabolic reprogramming has been demonstrated to have a significant impact on the biological behaviors of tumor cells, among which glycolysis is an important form. Recent research has revealed that the heightened glycolysis levels, the abnormal expression of glycolytic enzymes, and the accumulation of glycolytic products could regulate the growth, proliferation, invasion, and metastasis of tumor cells and provide a favorable microenvironment for tumor development and progression. Based on the distinctive glycolytic characteristics of tumor cells, novel imaging tests have been developed to evaluate tumor proliferation and metastasis. In addition, glycolytic enzymes have been found to serve as promising biomarkers in tumor, which could provide assistance in the early diagnosis and prognostic assessment of tumor patients. Numerous glycolytic enzymes have been identified as potential therapeutic targets for tumor treatment, and various small molecule inhibitors targeting glycolytic enzymes have been developed to inhibit tumor development and some of them are already applied in the clinic. In this review, we systematically summarized recent advances of the regulatory roles of glycolysis in tumor progression and highlighted the potential clinical significance of glycolytic enzymes and products as novel biomarkers and therapeutic targets in tumor treatment.

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Section: The Regulatory Role Of Glycolysis In Tumor Developmentmentioning

confidence: 99%

The regulatory roles and clinical significance of glycolysis in tumor

Qiao,

Hu,

Wang

2024

Cancer Communications

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Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway

Wang,

Jiang,

2024

Cancer Medicine

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BackgroundAs one of the most common malignancies, cervical cancer (CC) seriously affects women's health. This study aimed to investigate the biological function of Serinc2 in CC.MethodsSerinc2 expression was surveyed utilizing immunohistochemistry, western blot, and qRT‐PCR. CC cell viability, invasion, proliferation, migration, and apoptosis, were detected via CCK‐8, Transwell assay, colony formation, wound healing assay, and flow cytometry. Glucose consumption, lactate production, and ATP levels were determined by the corresponding kit. The protein expression of c‐Myc, PDK1, HK2, PFKP, LDHA, Snail, Vimentin, N‐cadherin, and E‐cadherin was detected via western blot. The interaction between the promoter of PFKP and Myc was confirmed through luciferase reporter assay and Chip assay. In vivo, to evaluate the function of Serinc2 on tumor growth, a xenograft mouse model was used.ResultsIn CC tissues and cells, Serinc2 was upregulated. In CC cells, knockdown of Serinc2 suppressed cell invasion, proliferation, migration, decreased the expression of Snail, Vimentin, N‐cadherin, HK2, PFKP, LDHA, and PDK1, increased E‐cadherin expression, reduced glucose consumption and the production of lactate and ATP, and induced cell apoptosis; Serinc2 overexpression led to the opposite results. Mechanically, Serinc2 promoted Myc expression, and Myc induced PFKP expression. Furthermore, overexpressed Myc abolished the inhibitive influences of Serinc2 knockdown on the malignant behaviors of CC cells. Additionally, knockdown of Serinc2 inhibited tumor growth and reduced the protein expression of c‐Myc, PFKP, LDHA, and PDK1 in vivo.ConclusionsKnockdown of Serinc2 inhibited the malignant progression of CC, which was achieved via Myc pathway. Our study provides novel insight into CC pathogenesis.

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Diverse roles of aldolase enzymes in cancer development, drug resistance and therapeutic approaches as moonlighting enzymes

Tang,

Cui

2024

Med Oncol

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Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation

Cited by 3 publications

References 45 publications

The regulatory roles and clinical significance of glycolysis in tumor

The regulatory roles and clinical significance of glycolysis in tumor

Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway

Diverse roles of aldolase enzymes in cancer development, drug resistance and therapeutic approaches as moonlighting enzymes

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