Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation

Rao, Mishal; Huang, Yung-Cheng; Liu, Chia-Chun; Meadows, Chandler; Cheng, Hui-Chun; Zhou, Minghui; Chen, Yu‐Chih; Xia, Xin; Goldberg, Jeffrey L; Williams, Andrew M.; Kuwajima, Takaaki; Chang, Kun-Che

doi:10.1038/s41598-023-32702-5

Cited by 12 publications

(4 citation statements)

References 94 publications

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“…Additionally, using a natural small molecule to inhibit aldose reductase was found to suppress microglia and macrophage migration and inflammatory cytokine secretion in mouse eyes [106,107]. Studies also showed that aldose reductase inhibition alleviated microglia activation triggered by beta-amyloid [66] and optic nerve injury [108], suggesting that aldose reductase blockade plays a protective role in the CNS and may be a therapeutic avenue for OPG. Table 1 is presented below.…”

Section: Targeting the Microenvironmentmentioning

confidence: 96%

The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Irshad,

Huang,

Rodriguez

et al. 2023

Brain Sciences

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Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.

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Section: Targeting the Microenvironmentmentioning

confidence: 96%

The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Irshad,

Huang,

Rodriguez

et al. 2023

Brain Sciences

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“…Studies have shown that increased AR activity is localized in, among others, pericytes, retinal endothelial cells, ganglion cells, Müller cells, retinal pigment epithelial cells and neurons. AR hyperactivity is involved in destruction of retinal cells [41]. Furthermore, the aldose reductase gene is characterized with the largest number of polymorphisms associated with DR [42].…”

Section: Disorders Of the Polyol Pathwaymentioning

confidence: 99%

Relationship between Biochemical Pathways and Non-Coding RNAs Involved in the Progression of Diabetic Retinopathy

Mrowicka,

Mrowicki,

Majsterek

2023

Preprint

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Diabetic retinopathy (DR) is a progressive blinding disease that affects vision and quality of life of patients and severely impacts society. This complication, caused by abnormal glucose metabolism, leads to structural, functional, molecular, and biochemical abnormalities in the retina. Oxidative stress (OS) and inflammation also play pivotal roles in the pathogenic process of DR, leading to mitochondrial damage and decrease in the mitochondrial function. DR causes retinal degeneration in glial and neural cells, while the disappearance of pericytes in retinal blood vessels leads to modifications in vascular regulation and stability. Clinical changes include dilatation and blood flow alterations in response to the reduce in retinal perfusion in retinal blood vessels, leading to vascular leakage, neovascularization and neurodegeneration. Thus, DR is a highly complex disease with various biological factors that contribute to its pathogenesis. The interplay between biochemical pathways and non-coding RNAs (ncRNAs) is essential for understanding the development and progression of DR. Abnormal expression of ncRNAs has been confirmed to promote the development of DR, suggesting that ncRNAs such as miRNAs, lnc-RNAs and circ-RNAs have potential as diagnostic biomarkers and theranostic targets in DR. This review provides an overview of interactions between abnormal biochemical pathways and dysregulated expression of ncRNAs under the influence of hyperglycemic environment in DR.

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“…Studies have shown that increased AR activity is localized in, among others, pericytes, retinal endothelial cells, ganglion cells, Müller cells, retinal pigment epithelial cells, and neurons. AR hyperactivity is involved in the destruction of retinal cells [ 41 ]. Furthermore, the aldose reductase gene is characterized by the largest number of polymorphisms associated with diabetic retinopathy [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Biochemical Pathways and Non-Coding RNAs Involved in the Progression of Diabetic Retinopathy

Mrowicka,

Mrowicki,

Majsterek

2024

JCM

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Diabetic retinopathy (DR) is a progressive blinding disease, which affects the vision and quality of life of patients, and it severely impacts the society. This complication, caused by abnormal glucose metabolism, leads to structural, functional, molecular, and biochemical abnormalities in the retina. Oxidative stress and inflammation also play pivotal roles in the pathogenic process of DR, leading to mitochondrial damage and a decrease in mitochondrial function. DR causes retinal degeneration in glial and neural cells, while the disappearance of pericytes in retinal blood vessels leads to alterations in vascular regulation and stability. Clinical changes include dilatation and blood flow changes in response to the decrease in retinal perfusion in retinal blood vessels, leading to vascular leakage, neovascularization, and neurodegeneration. The loss of vascular cells in the retina results in capillary occlusion and ischemia. Thus, DR is a highly complex disease with various biological factors, which contribute to its pathogenesis. The interplay between biochemical pathways and non-coding RNAs (ncRNAs) is essential for understanding the development and progression of DR. Abnormal expression of ncRNAs has been confirmed to promote the development of DR, suggesting that ncRNAs such as miRNAs, lncRNAs, and circRNAs have potential as diagnostic biomarkers and theranostic targets in DR. This review provides an overview of the interactions between abnormal biochemical pathways and dysregulated expression of ncRNAs under the influence of hyperglycemic environment in DR.

show abstract

Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation

Cited by 12 publications

References 94 publications

The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Relationship between Biochemical Pathways and Non-Coding RNAs Involved in the Progression of Diabetic Retinopathy

Relationship between Biochemical Pathways and Non-Coding RNAs Involved in the Progression of Diabetic Retinopathy

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