Aldosterone and dopamine receptors in the kidney: Sites for pharmacologic manipulation of renal function

Adam, W. R.; Danks, Janine A.; Goland, Gary J.

doi:10.1038/ki.1980.180

Cited by 28 publications

(8 citation statements)

References 76 publications

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“…Total output of epinephrine into urine is small relative to either norepinephrine or do pamine. The former is a function of increased activity of the entire sympathetic nervous sys tem while the latter is a function of produc tion by the kidneys [16,17]. It is not clear why the kidneys of cold-treated rats should in crease their production of dopamine.…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Treatment with Losartan Potassium (DuP 753) on the Elevation of Blood Pressure during Chronic Exposure of Rats to Cold

Fregly¹,

Rossi²,

Bergen³

et al. 1993

Pharmacology

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Elevation of diastolic, systolic, and mean blood pressures and cardiac hypertrophy occur in rats exposed to cold (5°C) for 1-3 weeks. The renin-angiotensin-aldosterone system is believed to play a role in the development of cold-induced hypertension since plasma renin activity increases within the first 2 weeks, presumably initiating the hypertensive process, and then returns to control level. The present study was designed to assess the role of angiotension II (Ang II) in the hypertensive process by chronic administration of losartan potassium, an Ang II i receptor antagonist. Twenty-four rats were divided into four equal groups. After a 1-week control period, one group was kept at 25°C while the remaining three groups were exposed to cold (5°C). One of the cold-treated groups was untreated while the remaining two were given losartan in drinking water at a concentration calculated to provide 56 and 112 mg/kg/day. The untreated cold-exposed group had a significant elevation of systolic blood pressure within 1 week of exposure to cold. Losartan at both doses prevented the elevation of blood pressure and blocked both the dipsogenic and vascular responses to administration of Ang II. Exposure to cold increased food intake, urine output and water intake significantly above that of warm-adapted controls. Treatment with losartan tended to decrease each of these toward the level of controls. At the conclusion of the seventh week of exposure to cold, the rats were sacrificed and heart, kidneys, and brown fat removed and weighed. Chronic exposure to cold increased the weight of heart, kidneys, and brown fat above that of warm-adapted controls. Treatment with losartan failed to prevent the increases in these organ weights. Thus, although treatment with losartan prevented the elevation of systolic blood pressure induced by chronic exposure to cold, it did not prevent cardiac and renal hypertrophy and the increase in brown fat. It would appear that losartan does not affect these and that an elevation of blood pressure does not sustain them.

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Section: Discussionmentioning

confidence: 99%

Effect of Chronic Treatment with Losartan Potassium (DuP 753) on the Elevation of Blood Pressure during Chronic Exposure of Rats to Cold

Fregly¹,

Rossi²,

Bergen³

et al. 1993

Pharmacology

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“…Dopamine is a naturally occurring agent that may be produced in the kidney as well as elsewhere [19], and it has been demonstrated in renal vascular tissue by fluo rescent techniques [20], To the present, renal receptors have been demonstrated almost exclusively in relation to dopaminergic control of blood flow [19]. At low dose ( < 3 ¡xg/kg/min i.v.)…”

Section: Discussionmentioning

confidence: 99%

Synergism of Dopamine and Furosemide in Diuretic-Resistant, Oliguric Acute Renal Failure

Lindner¹

1983

Nephron

104

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This paper describes our initial clinical findings in a small group of patients with acute oliguric renal failure, who were resistant to extracellular volume expansion and furosemide in large doses. Based on our experience in an experimental model of acute renal failure in the dog, we administered a combination of low-dose dopamine (1–3 µg/ kg/min i.v.) and furosemide (100–200 mg every 6–8 h). This combination was uniformly effective in inducing a brisk, lasting diuresis and was associated with either stable or reduced serum creatinine levels in two-thirds of the patients. No toxicity was found. These findings would warrant extensive study of this drug combination in a larger, well-controlled, randomized group with oliguric renal failure.

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“…The main actions of dopamine in the kidney at phar macological doses are natriuresis and vasodilatation [1,2], Thus, it is possible that dopamine acts on renal vascu lar and tubular dopaminergic receptors [3]. There are two subtypes of receptors for dopamine, DAI and DA2, in peripheral tissues, as Goldberg and Kohli [4] suggested in 1979.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Rat Kidney Dopamine Receptors and the Effects of Renal Denervation and Dopamine Infusion on These Receptors

Katayama¹,

Ogura²,

Ota³

1989

Nephron

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The characteristics of dopamine receptors, as well as the effects of denervation and dopamine infusion on dopamine receptors were studied using the radiolabeled receptor assay of [³H]-spiperone on rat kidney membrane preparations. The rat renal cortex was found to have a single class of [³H]-spiperone binding sites with a dissociation constant (K_d) of 13.5 ± 2.2 nM. However, neither sulpiride nor serotonin strongly interacted with [³H]-spiperone binding, suggesting that DA1 receptors were predominant in the rat renal cortex. Denervation was performed by surgically stripping the nerves from the renal artery and coating them with 10% phenol. Chronic denervation had no significant effect on the affinity or maximum binding capacity of the renal dopamine receptors, although diuresis and the disappearance of catecholamine fluorophores in the denervated rats were observed. Chronic infusion of dopamine was performed using an osmotic minipump, resulting in a decrease in the number of rat kidney dopamine receptors. These results suggest that the dopamine receptor subtype in the renal cortex was mainly DA1, and that the major source of dopamine which affected the dopamine receptors in the rat kidney was not the nerve ending, but rather the circulation.

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Aldosterone and dopamine receptors in the kidney: Sites for pharmacologic manipulation of renal function

Cited by 28 publications

References 76 publications

Effect of Chronic Treatment with Losartan Potassium (DuP 753) on the Elevation of Blood Pressure during Chronic Exposure of Rats to Cold

Effect of Chronic Treatment with Losartan Potassium (DuP 753) on the Elevation of Blood Pressure during Chronic Exposure of Rats to Cold

Synergism of Dopamine and Furosemide in Diuretic-Resistant, Oliguric Acute Renal Failure

Characteristics of Rat Kidney Dopamine Receptors and the Effects of Renal Denervation and Dopamine Infusion on These Receptors

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