Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy

Sabbadin, Chiara; Andrisani, Alessandra; Ambrosini, Guido; Bordin, Luciana; Donà, Gabriella; Manso, Jacopo; Ceccato, Filippo; Scaroni, Carla; Armanini, Decio

doi:10.3389/fendo.2019.00575

Cited by 20 publications

(12 citation statements)

References 64 publications

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“…Then, the network centering on TIMP1 , 3BHSD, and PTGIS was constructed ( Figure 5 A). It can be seen that TIMP1 participates in the HIF-1 signaling pathway (ko04066), 3BHSD participates in Aldosterone synthesis and secretion (ko04925), Ovarian Steroidogenesis (ko04913), and Steroid hormone biosynthesis (ko00140), and PTGIS participates in Arachidonic acid metabolism (ko00590), which are important in follicular and ovarian developments [ 36 , 37 , 38 , 39 ]. It is gratifying that differentially expressed miRNAs potentially targeting TIMP1 , 3BHSD, and PTGIS were screened, while these miRNAs were potentially sponged by lots of circRNAs; for clear presentation, only parts of prominent circRNAs were selected and shown in Figure 5 A.…”

Section: Resultsmentioning

confidence: 99%

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

Zhang

et al. 2021

Biology

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Estrous cycle is one of the placental mammal characteristics after sexual maturity, including estrus stage (ES) and diestrus stage (DS). Estrous cycle is important in female physiology and its disorder may lead to diseases, such as polycystic ovary syndrome, ovarian carcinoma, anxiety, and epilepsy. In the latest years, effects of non-coding RNAs and messenger RNA (mRNA) on estrous cycle have started to arouse much concern, however, a whole transcriptome analysis among non-coding RNAs and mRNA has not been reported. Here, we report a whole transcriptome analysis of goat ovary in estrus and diestrus periods. Estrus synchronization was conducted to induce the estrus phase and on day 32, the goats shifted into the diestrus stage. The ovary RNA of estrus and diestrus stages was respectively collected to perform RNA-sequencing. Then, the circular RNA (circRNA), microRNA (miRNA), long non-coding RNA (lncRNA), and mRNA databases of goat ovary were acquired, and the differential expressions between estrus and diestrus stages were screened to construct circRNA-miRNA-mRNA/lncRNA and lncRNA-miRNA/mRNA networks, thus providing potential pathways that are involved in the regulation of estrous cycle. Differentially expressed mRNAs, such as MMP9, TIMP1, 3BHSD, and PTGIS, and differentially expressed miRNAs that play key roles in the regulation of estrous cycle, such as miR-21-3p, miR-202-3p, and miR-223-3p, were extracted from the network. Our data provided the miRNA, circRNA, lncRNA, and mRNA databases of goat ovary and each differentially expressed profile between ES and DS. Networks among differentially expressed miRNAs, circRNAs, lncRNAs, and mRNAs were constructed to provide valuable resources for the study of estrous cycle and related diseases.

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Section: Resultsmentioning

confidence: 99%

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

Zhang

et al. 2021

Biology

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“…Further studies have supported the role of aldosterone in the inflammatory and autoimmune mechanisms underlying several diseases [12]. In particular, aldosterone has also been involved in some gynecological conditions characterized by inflammation and increased cardio-metabolic risk, such as polycystic ovary syndrome (PCOS), preeclampsia, uterine fibroids, and endometriosis [13]. A significant increase in aldosterone or aldosterone to renin ratio (ARR) has been found in PCOS [14] and preeclampsia [15], actively contributing to the inflammatory milieu of these diseases.…”

Section: Ofmentioning

confidence: 95%

Role of Renin-Angiotensin-Aldosterone System and Cortisol in Endometriosis: A Preliminary Report

Sabbadin

Saccardi

Andrisani

et al. 2022

IJMS

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Endometriosis is a chronic inflammatory disease associated with pelvic pain, infertility, and increased cardiovascular risk. Recent studies suggest a possible role of aldosterone as a pro-inflammatory hormone in the pathogenesis of the disease. Cortisol is also an important mediator of stress reaction, but its role is controversial in endometriosis. The aim of this study was to evaluate aldosterone and cortisol levels and blood pressure values in women with endometriosis. We measured blood pressure, plasma aldosterone, renin, cortisol, and dehydroepiandrosterone sulfate (DHEAS) in 20 women with untreated minimal or mild pelvic endometriosis compared with 20 healthy controls matched for age and body mass index. Aldosterone values were similar in the two groups, while renin was significantly lower and the aldosterone to renin ratio was significantly higher in patients with endometriosis than in controls. Systolic blood pressure was in the normal range, but significantly higher in patients with endometriosis. Morning plasma cortisol was normal, but significantly lower in patients with endometriosis compared with controls, while DHEAS to cortisol ratio was similar in the two groups. These preliminary results are evidence of increased biological aldosterone activity and dysregulation of the hypothalamic-pituitary-adrenal axis in early stages of endometriosis. These alterations could play a role in disease development, suggesting new therapeutic targets for aldosterone receptor blockers.

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“…Then the network centering on TIMP1, 3BHSD and PTGIS were constructed ( Figure 5A). It can be seen that TIMP1 participates in HIF-1 signaling pathway (ko04066); 3BHSD participates in Aldosterone synthesis and secretion (ko04925), Ovarian Steroidogenesis (ko04913) and Steroid hormone biosynthesis (ko00140); and PTGIS participates in Arachidonic acid metabolism (ko00590), which are important in follicular and ovarian developments [30][31][32][33]. It is gratifying that differentially expressed miRNAs potentially targeting TIMP1, 3BHSD and PTGIS were screened, while these miRNAs were potentially sponged by lots of circRNAs; for clear presentation, only parts of prominent circRNAs were selected and shown in Figure 5A.…”

Section: Sequencing and Analysis Of Mirnamentioning

confidence: 99%

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

Zhang

et al. 2021

Preprint

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BackgroundEstrous cycle is one of female characteristics after sexual maturity, including estrus (ES) and diestrus (DS) stages. Estrous cycle is important in female physiology and its disorder may lead to diseases. In the latest years, effects of non-coding RNAs and mRNA on estrous cycle start to arouse much concern, however, a whole transcriptome analysis among non-coding RNAs and mRNA has not been reported.ResultsHere we report a whole transcriptome analysis of goat ovary in estrus and diestrus periods. Estrus synchronization was conducted to induce the estrus phase and on day 32, the goats naturally shifted into diestrus stage. The ovary RNA of estrus and diestrus stages was respectively collected to perform RNA-sequencing. Then the circular RNA; microRNA; long non-coding RNA; mRNA databases of goat ovary were acquired, and the differentially expressions between estrus and diestrus stages were screened to construct circRNA-miRNA-mRNA/lncRNA and lncRNA-miRNA/mRNA networks, thus providing potential pathways that involved in the regulation of estrous cycle. Differentially expressed mRNAs, such as MMP9, TIMP1, 3BHSD and PTGIS, and differentially expressed microRNAs, such as miR-21-3p，miR-202-3p and miR-223-3p, which play key roles in estrous cycle regulation were extracted from the network.ConclusionsOur data provided the miRNA, circRNA, lncRNA and mRNA databases of goat ovary and each differentially expressed profile between ES and DS. Networks among differentially expressed miRNAs, circRNAs, lncRNAs and mRNAs were constructed to provide valuable resources for the study of estrous cycle and related diseases.

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Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy

Cited by 20 publications

References 64 publications

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

Role of Renin-Angiotensin-Aldosterone System and Cortisol in Endometriosis: A Preliminary Report

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

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