Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma

The Decrease of Mineralcorticoid Receptor Drives Angiogenic Pathways in Colorectal Cancer

“…[13], [38] When compared with our results, the data obtained in HUVEC showed that KDR mRNA was similarly down-regulated by aldosterone, although the reduction was less pronounced (30% vs 40%) even if they used a higher concentration of aldosterone (10 nM vs 3 nM).…”

PPAR Gamma and Angiogenesis: Endothelial Cells Perspective

“…Consistent with these results, inhibition of PPAR γ in pulmonary arterial endothelial cells resulted in upregulation of VEGF-R2 [51]. By contrast, in one study, VEGF-R2 expression was found to be enhanced in response to PPAR γ activation by troglitazone and attenuated by GW9662, a specific antagonist of PPAR gamma [52]. …”

“…Recently, Fujii and coworkers demonstrated that, in HUVECs, VEGFR-2 expression was enhanced in response to PPAR γ activation by troglitazone and attenuated by GW9662, a specific inhibitor. In the same cells, endothelial morphogenesis measured in a tube formation assay was also stimulated by troglitazone and inhibited by GW9662, indicating that PPAR γ activation positively mediates angiogenesis [52]. EC proliferation was also induced with low concentrations of TZDs [59].…”

Mineralocorticoid receptor signaling: Crosstalk with membrane receptors and other modulators

“…These effects are decreased in PlGF knockout mice, suggesting that MR-induced vascular remodeling is mediated by PlGF/VEGFR1 in injured vessels. Conversely, aldosterone and MR inhibit tube formation on Matrigel in HUVEC and angiogenesis in vivo by downregulating PPARc and VEGFR2 in vascular endothelial cells [71]. While VEGFR2 is closely linked to induction of angiogenesis, the role of VEGF1 in angiogenesis has been more ambiguous.…”