2011
DOI: 10.1093/eurheartj/ehr266
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Aldosterone promotes atrial fibrillation

Abstract: Aldosterone causes a substrate for atrial arrhythmias characterized by atrial fibrosis, myocyte hypertrophy, and conduction disturbances. The described model imputes atrial proarrhythmia directly to aldosterone, since ventricular haemodynamics appeared unaltered in this model. This mechanism may have therapeutical impact for primary and secondary prevention of AF.

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Cited by 161 publications
(99 citation statements)
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“…High expression of mineralocorticoid receptors frequently observed during AF caused atrial ionic remodelling [16], which was further attenuated by spironolactone. Animal in vivo model of injected aldosterone resulted in anisotropy of atrial conduction, recorded in a epicardial stimulation map [17]. Furthermore, registered conduction abnormalities were associated with structural remodelling represented by atrial fibrosis and hypertrophy, thus being responsible for forming a substrate for atrial arrhythmias.…”
Section: Discussionmentioning
confidence: 99%
“…High expression of mineralocorticoid receptors frequently observed during AF caused atrial ionic remodelling [16], which was further attenuated by spironolactone. Animal in vivo model of injected aldosterone resulted in anisotropy of atrial conduction, recorded in a epicardial stimulation map [17]. Furthermore, registered conduction abnormalities were associated with structural remodelling represented by atrial fibrosis and hypertrophy, thus being responsible for forming a substrate for atrial arrhythmias.…”
Section: Discussionmentioning
confidence: 99%
“…However it is currently unknown whether improvements in the hemodynamic situation or direct atrial effects of MR antagonist treatment are responsible for the beneficial effects. Recently, aldosterone was found to be able to induce AF and fibrosis (14). Aldosterone passes the cell membrane and binds at and activates the intracellular localized MR (6).…”
Section: Atrial Fibrillation (Af)mentioning
confidence: 99%
“…Si bien la mayoría de los trabajos existentes se centran en el rol deletéreo de angiotensina II y el uso de IECA o ARA2, estudios recientes seña-lan la participación de aldosterona y del RM en la fisiopatología de esta arritmia. Investigaciones en animales han demostrado que aldosterona es capaz de inducir fibrosis auricular, hipertrofia de los cardiomiocitos y producir alteraciones de la conducción que contribuyen al desarrollo de arritmias auriculares 40 . Esto podría deberse, al menos en parte, a un aumento de la expresión génica del RM en aurícula izquierda en este tipo de pacientes 41,42 .…”
Section: Arm En Fibrilación Auricularunclassified