2017
DOI: 10.1016/j.jtho.2017.02.012
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Alectinib for Patients with ALK Rearrangement–Positive Non–Small Cell Lung Cancer and a Poor Performance Status (Lung Oncology Group in Kyushu 1401)

Abstract: Alectinib is a treatment option for patients with ALK rearrangement-positive NSCLC and a poor PS.

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Cited by 47 publications
(38 citation statements)
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“…However, these results must be interpreted with caution due to the different study populations enrolled; that is, the pre–approval studies did not include patients with ECOG PS ≥2, or with crizotinib pretreatment, and included fewer patients aged ≥75 years. Furthermore, we did not see any increased incidence of ADR in patients with ECOG PS ≥2 vs ≤1, suggesting that alectinib may be tolerable in patients with poor PS, as previously reported, or in those who had been pretreated with crizotinib vs crizotinib‐naïve patients. Visual disturbances and gastrointestinal effects, which are frequently reported with crizotinib, occurred at a low rate with alectinib, as observed in AF‐001JP …”
Section: Discussionsupporting
confidence: 80%
“…However, these results must be interpreted with caution due to the different study populations enrolled; that is, the pre–approval studies did not include patients with ECOG PS ≥2, or with crizotinib pretreatment, and included fewer patients aged ≥75 years. Furthermore, we did not see any increased incidence of ADR in patients with ECOG PS ≥2 vs ≤1, suggesting that alectinib may be tolerable in patients with poor PS, as previously reported, or in those who had been pretreated with crizotinib vs crizotinib‐naïve patients. Visual disturbances and gastrointestinal effects, which are frequently reported with crizotinib, occurred at a low rate with alectinib, as observed in AF‐001JP …”
Section: Discussionsupporting
confidence: 80%
“…Molecular-targeted drugs usually showed milder toxicity than cytotoxic chemotherapy [ 13 16 ]. It is also important that they showed beneficial results in patients with poor PS in relatively small, but prospective studies [ 17 , 18 ].…”
Section: Outlinementioning
confidence: 99%
“…The reasons for exclusion were not relevant (n = 50), retrospective chart reviews (n = 7), no specific data for outcome measures (n = 7), no sufficient ALK-positive NSCLC (n = 3), data overlapping (n = 16), and no available data on results (n = 5). A total of 20 clinical trials were included in the final analysis with 18 studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]26,28,29] in English and two studies [25,27] in Chinese.…”
Section: Selection Of Relevant Studiesmentioning
confidence: 99%
“…Except for 13 global multicenter trials [10,11,14,[16][17][18][19][20][21][22][23][24]29], the seven remaining studies were conducted in China [12,[25][26][27] and Japan [13,15,28]. Four studies [10,12,21,26] (1344 patients), three studies [11,16,28] (406 patients), and three studies [14,15,23] (243 patients) used a single arm design for the efficacy of crizotinib, ceritinib, and alectinib, respectively. Five studies [18][19][20]25,27] (967 patients), two studies [22,24] (607 patients), one study [29] (72 patients), and two studies [13,17] (510 patients) investigated the efficacy of crizotinib versus chemotherapy, ceritinib versus chemotherapy, alectinib versus chemotherapy, and alectinib versus crizotinib, respectively.…”
Section: General Characteristics Of Studiesmentioning
confidence: 99%
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