Alexia without agraphia in Creutzfeldt–Jakob disease

Adair, John C.; Cooke, Norma; Jankovic, Joseph

doi:10.1016/j.jns.2007.06.007

Cited by 15 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This pattern evolved during the course of the disease showing a strong effect of the 'number of letters' in the second period, with an in-creasing of 300 msec for additional letter. We may conclude that L.P. showed a 'letter by letter' alexia, which has been already reported in patients with Posterior Cortical Atrophy [1,9,13,14,16], and is typically associated with damage involving the temporo-occipital regions.…”

Section: Discussionsupporting

confidence: 73%

“…However, the specific features of alexia and their evolution have been seldom investigated. A number of reports refer to the reading difficulties in PCA patients as "pure alexia" [1,9,13,14,16], but several varieties of alexia have been described in PCA patients, such as neglect alexia, alexia with simultanagnosia [20], "apperceptive" [22], attentional alexia [27], or a central reading disorder with lexical and spatial agraphia [3]. This study aims at highlighting the clinical evolution of different types of alexia in two PCA patients, one with a neuropsychological picture compatible with an initial and unilateral involvement (left) of the ventral areas, and the other with features of the dorsal variant and a prominent involvement of right hemisphere.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Evolution of Alexia in Two Cases of Posterior Cortical Atrophy

Catricalà

Rosa

Ortelli

et al. 2011

Behavioural Neurology

View full text Add to dashboard Cite

Posterior cortical atrophy (PCA) is an uncommon presentation of Alzheimer's disease (AD), characterised by prevalent anatomo-functional involvement of posterior cortical areas. Accordingly, the main clinical features at onset are disorders of high-order visual processing, such as alexia and impairments of visuo-spatial and visuo-constructional abilities. The clinical features in the early stages of disease are variable, and they have been suggested to stem from prevalent ventral or dorsal brain pathology, and/or asymmetric hemispheric involvement. With disease progression, these differences tend to blur with the increasing severity of neuropsychological dysfunction. We report two PCA patients showing different patterns of reading impairment (respectively, letter-by-letter reading and neglect dyslexia). A follow-up study suggested that the qualitative features of alexia remain distinctive with disease evolution. In addition, single photon emission tomography (SPECT) studies revealed different patterns of hypoperfusion, consistent with the alexia types. A careful reading assessment can provide important insights to the pattern of progression of the disease in patients with PCA up to the late stages of the pathology.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

The Evolution of Alexia in Two Cases of Posterior Cortical Atrophy

Catricalà

Rosa

Ortelli

et al. 2011

Behavioural Neurology

View full text Add to dashboard Cite

show abstract

“…Other causes are demyelination from multiple sclerosis, migraine, seizures, infection (encephalitis or abscess), prion disease, vascular malformations, neoplasm, carbon monoxide poisoning, posterior reversible encephalopathy, eclampsia, progressive multifocal leukoencephalopathy, and COVID-19 [7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Clinicoradiological Features of Alexia Without Agraphia

Carranza-Rentería,

Swerdloff

2024

Cureus

View full text Add to dashboard Cite

Alexia without agraphia is a striking vascular syndrome of the acquired inability to read words just written down. This syndrome occurs after lesions in the splenium of the corpus callosum that disconnect the angular gyrus from the visual pathway. Most of the time, a lesion in the left occipital lobe is also present, and patients present with a visual field deficit. It is a classic neurological syndrome that is rarely seen. We present two cases of alexia without agraphia seen in our hospital the same week.

show abstract

“…Examples of focal/lateralized neurological signs/symptoms in sCJD are: i) focal higher cortical deficits, such as aphasia, 7 alexia without agraphia, 8 and alien limb phenomenon; 9 ii) movement disorders other than myoclonus, 10 focal dystonia, 11 and cerebellar ataxia; 12 iii) visual abnormalities such as hemianopia, diplopia, 13 and the well-known Heidenhain phenotype; 14 motor weakness, such as hemiparesis and monoparesis; 15,16 and focal seizure activity, particularly EPC. 17–19 In many of these cases, the focal deficit is the initial manifestation of sCJD, and in some, the focal symptoms are acute in onset leading to an incorrect diagnosis of stroke.…”

Section: Discussionmentioning

confidence: 99%

Sporadic Creutzfeldt-Jakob disease with focal findings: caveats to current diagnostic criteria

et al. 2013

View full text Add to dashboard Cite

The clinical diagnosis of Creutzfeldt-Jakob disease (CJD) is largely based on the 1998 World Health Organization diagnostic criteria. Unfortunately, rigid compliance with these criteria may result in failure to recognize sporadic CJD (sCJD), especially early in its course when focal findings predominate and traditional red flags are not yet present. A 61-year-old man presented with a 3-week history of epilepsia partialis continua (jerking of the left upper extremity) and a 2-week history of forgetfulness and left hemiparesis; left hemisensory neglect was also detected on admission. Repeated brain magnetic resonance imaging (MRI) showed areas of restricted diffusion in the cerebral cortex, initially on the right but later spreading to the left. Electroence-phalography (EEG) on hospital days 7, 10, and 14 showed right-sided periodic lateralized epileptiform discharges. On day 20, the EEG showed periodic sharp wave complexes leading to a diagnosis of probable sCJD and subsequently to definite sCJD with brain biopsy. Neurological decline was relatively fast with generalized myoclonus and akinetic mutism developing within 7 weeks from the onset of illness. CJD was not immediately recognized because of the patient's focal/lateralized manifestations. Focal/lateralized clinical, EEG, and MRI findings are not uncommon in sCJD and EEG/MRI results may not be diagnostic in the early stages of sCJD. Familiarity with these caveats and with the most current criteria for diagnosing probable sCJD (University of California San Francisco 2007, MRI-CJD Consortium 2009) will enhance the ability to recognize sCJD and implement early safety measures.

show abstract

Alexia without agraphia in Creutzfeldt–Jakob disease

Cited by 15 publications

References 23 publications

The Evolution of Alexia in Two Cases of Posterior Cortical Atrophy

The Evolution of Alexia in Two Cases of Posterior Cortical Atrophy

Clinicoradiological Features of Alexia Without Agraphia

Sporadic Creutzfeldt-Jakob disease with focal findings: caveats to current diagnostic criteria

Contact Info

Product

Resources

About