Alexithymia and immunoendocrine parameters in patients affected by systemic lupus erythematosus and rheumatoid arthritis

Vadacca, Marta; Bruni, Renato; Caccipaglia, F.; Serino, F.; Arcarese, Luisa; Buzzulini, Francesca; Coppolino, G.; Rigon, Amelia; Terminio, Nicolò; Afeltra, Antonella

doi:10.4081/reumatismo.2008.50

Cited by 11 publications

(15 citation statements)

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“…Alexythimia is characterized by difficulty in recognizing and identifying emotions, dysfunction in distinguishing emotions from somatosensory feelings and by a particular cognitive attitude to concrete experiences (46). Some studies on small cohorts have found a higher prevalence of alexythimia in patients with autoimmune diseases (RA, SLE) [46]. Recently, Van Leeuwen et al observed that patients with pSS not differ from controls in terms of the processing and regulation of emotions, but rather in terms of interpretation and expression of the same feelings in accordance with the definition of alexythimia [47].…”

Section: Discussionmentioning

confidence: 99%

Neurological Involvement in Primary Sjögren Syndrome: A Focus on Central Nervous System

et al. 2014

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ObjectivesSjögren syndrome is an autoimmune disease involving mainly salivary and lacrimal glands. Beyond widely described PNS involvement, high variable prevalence of CNS manifestations ranging from 2.5 and 60% of all pSS patients has been reported, without specific syndrome definition. The aim of this cohort study was to evaluate the prevalence of CNS signs and symptoms in pSS patients and to identify possible biomarkers of CNS damage.Methods120 patients with pSS diagnosis according to the 2002 American-European Consensus Group criteria were enrolled after exclusion of secondary causes. All patients underwent to a wide neurological, neuropsychological, psychiatric, neuroradiological and ultrasonographic evaluation.ResultsCentral and peripheral nervous system involvement was observed in 81 patients with a prevalence of 67.5%. The prevalence of CNS involvement was significantly higher than PNS disease (p 0.001). 68 patients (84%) shown non-focal CNS symptoms and 64 (79%) focal CNS deficits with headache as the most common feature (46.9%), followed by cognitive (44.4%) and mood disorders (38.3%). Particularly, we observed a high prevalence of migraine without aura, subcortical frontal executive functions and verbal memory impairment and apathy/alexythimia. MR spectroscopy revealed a reduction of NAA levels or NAA/Cr ratio decrease in subcortical frontal and basal ganglia white matter, while ultrasonography showed an impairment of microvasculature response. At multivariate analysis, headache, cognitive disorders and psychiatric symptoms was significantly associated to serological markers (anti-SSA), MRS and ultrasonographic features.ConclusionsThe higher prevalence of MWO-mimic headache, cognitive dys-esecutive syndrome and mood disorders observed in this series confirmed previous evidences of a higher diffused CNS compromission rather than focal involvement such as SM-like clinical course or NMO-like syndrome. The association with immunological biomarkers, metabolic cerebral dysfunction and microvascular damage suggests a possible endothelial dysfunction of the cerebral microcirculation or a potential inflammation-mediated shift of the neurovascular coupling.

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Section: Discussionmentioning

confidence: 99%

Neurological Involvement in Primary Sjögren Syndrome: A Focus on Central Nervous System

et al. 2014

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“…We further investigated the possible relation between alexithymia, inflammation and neuro-endocrine dysregulation, assessing serum levels of prolactin (PRL), human growth hormone (hGH), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha. In SLE patients with alexithymia we found hyper-expression of PRL compared to nonalexithymia ones, however, there were no difference in the expression of inflammatory markers [15].…”

Section: Alexithymia In Slementioning

confidence: 52%

Alexithymia in Systemic Lupus Erythematosus: A Tight Relation with Mood States

Margiotta¹,

Vadacca²

2016

Rheumatology (Sunnyvale)

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The difficulty in identifying, differentiating and expressing emotions is a neuropsychological condition called alexithymia. During the last years it has grown the interest of scientific community for alexithymia, in particular in chronic conditions. Crescent literature data demonstrated that a considerable number of SLE patients present difficulty not only in identifying, differentiating, and articulating emotions but also in differentiating them from bodily sensations, configuring the alexithymia complaint. Alexithymia seems to be not related to SLE disease activity but tightly related to mood states. Identify proper pharmacological and psychological approach to alexithymia in SLE patients is a major challenge for future research.

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“…5 Çalışmalarda aleksitimik iletişim biçiminin başlangıçta psikosomatik hastalıklara özgü olduğu belirtilmişse de, günümüzde yalnızca bu hastalıklarda değil sağlıklı bireylerde de görüldüğü vurgulanmaktadır. 4,[6][7][8][9][10][11] Aleksitiminin ortaya çıkmasında sosyokültürel, kalıtsal ve çevresel faktörlerin etkili olduğu belirtilmektedir. Sosyoekonomik gelir seviyesi düşük olanlarda, kadınlarda ve ilerleyen yaşlarda aleksitimi görülme sıklığı artmaktadır.…”

Section: Introductionunclassified

Üniversite Öğrencilerinde Ağrı, Aleksitimi, Emosyonel Durum ve Yaşam Kalitesinin Değerlendirilmesi

Kurtaran¹,

Baktır²,

Abanoz³

et al. 2019

Sakarya Medical Journal

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Orcid :Mehmet Kurtaran: https://orcid.org/0000-0001-8257-4400 Seda Baktır: https://orcid.org/0000-0002-3753-5135 Ebru Şeker Abanoz: https://orcid.org/0000-0002-7810-3654İpek Yeldan: https://orcid.org/0000-0002-6344-4157 ARAŞTIRMA MAKALESİ / Research Article ÖzAmaç Bu çalışmada üniversite öğrencilerinde kas-iskelet sistemi şikayetleri, duyguları tanıma ve açıklamada zorluk olarak tanımlanan aleksitimi, depresif belirti yaygınlığı ve yaşam kalitesi arasındaki ilişkiyi incelemek amaçlandı. ( Sakarya Tıp Dergisi 2019, 9(3):433-441 ) Gereç ve YöntemlerÇalışmaya 18-25 yaş arası 396 (233 kadın, 163 erkek) üniversite öğrencisi dahil edildi. Kas iskelet sistemi rahatsızlıkları "Genişletilmiş Nordic Kas İskelet Sistemi Anketi (GNKİSA)" ,aleksitimi varlığı "Toronto Aleksitimi Ölçeği (TAÖ)", depresif belirti "Beck Depresyon Ölçeği (BDÖ)", yaşam kalitesi "Kısa Form-36 (SF-36)" kullanılarak değerlendirildi. Tanımlayıcı ve korelasyon analizi yapıldı, istatiksel anlamlılık için p<0,05 kabul edildi. Bulgular Olguların yaş ortalamaları 20,48±1,80 yıl idi. En sık ağrı yaşanan bölgeler dört zaman dilimi için (yaşamları boyunca, son 12 ay, son 4 hafta ve değerlendirmenin yapıldığı gün) sırasıyla bel, boyun ve sırt idi. Yaşamları boyunca herhangi bir dönemde ağrı sıklığı belde (%49,20), boyunda (%43,70) ve sırtta (%40,20) idi. TAÖ skoru ortalaması 55,64±9,33, BDÖ skoru 11,73±9,38 idi. Olguların %23,70'si aleksitimik özelliğe, %50,80'i depresif belirtiye sahip idi. Olguların bel ve boyun ağrıları ile depresif belirtileri arasında korelasyon bulundu (p<0,05). Boyun, omuz, sırt ve bel ağrıları ile SF-36 alt bölümleri arasında korelasyon bulundu (p<0,05). Sonuç Olgularımızda kas iskelet sistemi ağrılarının tüm zaman dilimlerinde en sık omurgada olduğu bulundu. Bu durum öğrencilerin günlük yaşamlarında uzun süre sabit vücut pozisyonlarına maruz kalmasından kaynaklanabilir. Sonuçlarımız bel ve boyun bölgesindeki ağrı ile depresif belirti arasında ilişki olduğunu göstermektedir. Boyun, omuz, sırt ve bel ağrıları ile yaşam kalitesi arasında ilişki bulunmakta olup ağrı şiddeti arttıkça yaşam kalitesini olumsuz etkilemektedir. Anahtar Kelimeler aleksitimi; depresif belirti; kas iskelet sistemi ağrısı; yaşam kalitesi AbstractObjective The aim of this study was to investigate the relationship between musculoskeletal complaints, alexithymia defined as difficulty in the description and expression of emotions, prevalance of depressive symptoms and quality of life in university students.. ( Sakarya Med J 2019, 9(3):433-441 ). Materials and Methods396 (233 female, 163 male) university students aged between 18-25 were included in this study. Expanded Nordic Musculoskeletal Questionnaire was used to evaluate the musculoskeletal disorders, Toronto Alexithymia Scale was used to evaluate alexithymia, Beck Depression Inventory was used to evaluate the depressive symptoms, Short Form-36 was used to evaluate the quality of life. The descriptive and correlation statistical analysis were performed, p<0.05 value was accepted for statistical significance.Results ...

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Alexithymia and immunoendocrine parameters in patients affected by systemic lupus erythematosus and rheumatoid arthritis

Cited by 11 publications

References 34 publications

Neurological Involvement in Primary Sjögren Syndrome: A Focus on Central Nervous System

Neurological Involvement in Primary Sjögren Syndrome: A Focus on Central Nervous System

Alexithymia in Systemic Lupus Erythematosus: A Tight Relation with Mood States

Üniversite Öğrencilerinde Ağrı, Aleksitimi, Emosyonel Durum ve Yaşam Kalitesinin Değerlendirilmesi

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