2018
DOI: 10.1371/journal.pone.0204520
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ALG-2 participates in recovery of cells after plasma membrane damage by electroporation and digitonin treatment

Abstract: The calcium binding protein ALG-2 is upregulated in several types of cancerous tissues and cancer cell death may be a consequence of ALG-2 downregulation. Novel research suggests that ALG-2 is involved in membrane repair mechanisms, in line with several published studies linking ALG-2 to processes of membrane remodeling and transport, which may contribute to the fitness of cells or protect them from damage. To investigate the involvement of ALG-2 in cell recovery after membrane damage we disrupted the PDCD6 ge… Show more

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Cited by 10 publications
(9 citation statements)
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“…This cellular response to stress was also documented at the proteomic level by increases in the abundance of the deglycase DJ-1 (Q99LX0), formylglutathione hydrolase esd (Q9R0P3), and protein pdcd6 (P12815), which is involved in membrane repair [ 27 ].…”
Section: Discussionmentioning
confidence: 99%
“…This cellular response to stress was also documented at the proteomic level by increases in the abundance of the deglycase DJ-1 (Q99LX0), formylglutathione hydrolase esd (Q9R0P3), and protein pdcd6 (P12815), which is involved in membrane repair [ 27 ].…”
Section: Discussionmentioning
confidence: 99%
“…Intriguingly, follow-up studies shed doubt on this conclusion, since the alg-2 knockout mice grow normally, as well as with functional T cell development and apoptosis, suggesting a redundancy, or noncritical function of ALG-2 in vivo. Even so, the significance of ALG-2 has been acknowledged, including its involvement in ESCRT-related vesicle transportation, cell plasma membrane repair, and inhibition of HIV infection [26][27][28] . Additionally, a number of ALG-2 interacting partners have been identified, including Alix 29,30 , TSG101 31 , HEBP2 28 , and SEC31 [32][33][34] , which were found to interact with ALG-2 by either a type I (PPYPXXPGYP) or type II (PXPGF) ALG-2 binding motif 35,36 .…”
Section: Introductionmentioning
confidence: 99%
“…The rapidly increasing internal Ca 2+ concentration after injury is detected by Ca 2+ -responsive proteins, which function as sensors within the repair machinery (Horn and Jaiswal 2018;Nakamura et al 2018). In animal cells, for example, the Ca 2+ -binding penta-EF-hand protein ALG-2 (apoptosislinked gene-2) initiates the accumulation of ALG-2-interacting protein X (ALIX), and the ESCRT-III and Vps4 complex at the injured cell membrane, resulting in cell recovery by shedding of the damaged site (Scheffer et al 2014;la Cour et al 2018).…”
mentioning
confidence: 99%