Algae: A Functional Food with a Rich History and Future Superfood

Rajauria, Gaurav; Yuan, Yue

doi:10.1002/9781119542650.ch1

Cited by 1 publication

(1 citation statement)

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“…Microalgae biomass and their bioactive compounds, such as polyunsaturated fatty acids (PUFAs), pigments, amino acids, peptides, scytonemins, pterins and phenolic compounds, have been shown to demonstrate a wide range of therapeutic effects [ 18 ]. Importantly, some of the microalgae and bioactive compounds exhibit antioxidant, anti-inflammatory, and immune-modulatory properties, and improve insulin sensitivity that could potentially alleviate diabetes mellitus [ 18 , 19 , 20 , 21 ]. Table 1 summarizes the bioactive compounds present in various sources that have been particularly identified in certain microalgae species and their activity on diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus

Tamel Selvan,

Goon,

Makpol

et al. 2023

Marine Drugs

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Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade inflammation play crucial roles in the pathophysiology of diabetes mellitus. There has been a growing interest in applying natural products to improve metabolic derangements without the side effects of anti-diabetic drugs. Microalgae biomass or extract and their bioactive compounds have been applied as nutraceuticals or additives in food products and health supplements. Several studies have demonstrated the therapeutic effects of microalgae and their bioactive compounds in improving insulin sensitivity attributed to their antioxidant, anti-inflammatory, and pancreatic β-cell protective properties. However, a review summarizing the progression in this topic is lacking despite the increasing number of studies reporting their anti-diabetic potential. In this review, we gathered the findings from in vitro, in vivo, and human studies to discuss the effects of microalgae and their bioactive compounds on diabetes mellitus and the mechanisms involved. Additionally, we discuss the limitations and future perspectives of developing microalgae-based compounds as a health supplement for diabetes mellitus. In conclusion, microalgae-based supplementation has the potential to improve diabetes mellitus and be applied in more clinical studies in the future.

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