Algae Extract as a Potential Feed Additive

Korczyński, Mariusz; Witkowska, Zuzanna; Opaliński, Sebastian; Świniarska, Marita; Dobrzański, Zbigniew

doi:10.1002/9783527679577.ch34

Cited by 9 publications

(11 citation statements)

References 123 publications

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“…Therefore, we required in vivo evidence supporting the in vitro-based antioxidant activity of our compounds. In this respect, Saccharomyces cerevisiae is a model organism used to investigate oxidative stress and the effect of nutraceuticals in resistance to oxidative stress [ 16 , 28 , 29 , 30 ], among many other biological processes linked to human health. Actually, the yeast S. cerevisiae had become a model for the study of effects of nutraceuticals and its transfer to humans due to the new EU regulation (EC 1924/2006), because it is easy to handle, millions of cells can be studied in a single-small culture, and its genetics, biochemistry and physiology are transferrable.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities

et al. 2020

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Antioxidant compounds, including polyphenols, have therapeutic effects because of their anti-inflammatory, antihypertensive, antithrombotic and antiproliferative properties. They play important roles in protecting the cardiovascular and neurological systems, by having preventive or protective effects against free radicals produced by either normal or pathological metabolism in such systems. For instance, resveratrol, a well-known potent antioxidant, has a counteracting effect on the excess of reactive oxygen species (ROS) and has a number of therapeutic benefits, like anti-inflammatory, anti-cancer and cardioprotective activities. Based on previous work from our group, and on the most frequent OH substitutions of natural polyphenols, we designed two series of synthetically accessible bis-polyhydroxyphenyl derivatives, separated by amide or urea linkers. These compounds exhibit high antioxidant ability (oxygen radical absorbance capacity (ORAC) assay) and interesting radical scavenging activity (RSA) values (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and α,α-diphenyl-β-picrylhydrazyl (DPPH) tests). Some of the best polyphenols were evaluated in two biological systems, endothelial cells (in vitro) and whole aorta (ex vivo), highly susceptible for the deleterious effects of prooxidants under different inflammatory conditions, showing protection against oxidative stress induced by inflammatory stimuli relevant in cardiovascular diseases, i.e., Angiotensin II and IL-1β. Selected compounds also showed strong in vivo antioxidant properties when evaluated in the model organism Saccharomyces cerevisiae.

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Section: Resultsmentioning

confidence: 99%

Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities

et al. 2020

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“…Korczyński et al indicated that currently there is a need to search for new feed additives that will contribute to high quality products and farm animal welfare [ 32 ]. Among the materials of natural origin, seaweeds may play the role of functional fodder additives.…”

Section: Algal Extracts As Components Of Feed Additivesmentioning

confidence: 99%

“…As it was mentioned, the regulation of European Union (No 575/2011, 16 June 2011) places algae in the list of feed materials. Algae can be fed to animals because they contain polysaccharides such as fucoidan and laminarin, which are known to possess antibacterial properties and have a positive effect on intestinal microflora, as well as essential amino acids, proteins (e.g., lectins), essential unsaturated fatty acids, especially from group n -3, micro- and macroelements, polyphenols and pigments that exhibit strong antioxidative activity (treatment and prevention of numerous diseases) and can additionally to improve the coloration of animal origin products [ 32 , 89 ].…”

Section: Algal Extracts As Components Of Feed Additivesmentioning

confidence: 99%

“…The application of supercritical algal extracts to drinking water of laying hens is a new approach proposed by Korczyński et al (2015). Algal extracts applied in feeding experiments of animals could contribute to the biofortification of the products of animal origin in biologically active compounds [ 32 ].…”

Section: Algal Extracts As Components Of Feed Additivesmentioning

confidence: 99%

“…According to the Web of Knowledge, there is no literature data concerning this issue. Algae have a high potential for the application in animal feeding due to the content of polysaccharides, proteins, PUFAs, polyphenols, pigments and minerals [ 32 ]. The Commission Regulation (EU) No 575/2011 of 16 June 2011 places algae on the list of feed materials placed.…”

Section: Introductionmentioning

confidence: 99%

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Plant Growth Biostimulants, Dietary Feed Supplements and Cosmetics Formulated with Supercritical CO2 Algal Extracts

2017

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The review paper presents the use of algal extracts as safe and solvent-free components of plant growth biostimulants, dietary feed additives and cosmetics. Innovative technology that uses extracts obtained by supercritical CO2 extraction, as a method of isolation of biologically active compounds from algal biomass, is presented. An important part of the complete technology is the final formulation of the product. This enabled realization of the further step which was assessment of the utilitarian properties of the extract-based products. The extracts were analysed for the presence of biologically active molecules (e.g., plant hormones, polyphenols) which provide useful properties such as antioxidant, antiviral, anti-inflammatory and antibacterial. The bio-products were tested in germination tests and underwent field trials to search for plant growth biostimulatory properties. Tests on animals (laying hens experiments) were conducted to assess pro-health properties of new dietary feed supplement. Another application were cosmetic formulations (dermatological tests). The results of the application tests were very promising, however further studies are required for the registration of the products and successful implementation to the market.

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