Algal Polysaccharides and Health

Mišurcová, Ladislava; Orsavová, Jana; Ambrožová, Jarmila Vávra

doi:10.1007/978-3-319-16298-0_24

Cited by 16 publications

(5 citation statements)

References 126 publications

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“…They are being utilized as thickening or gelling agents (Delattre et al, 2009 , 2011 ; Kraan, 2012 ). In addition, they have immunomodulatory, antibacterial, anticoagulant, antimutagenic, radioprotective, anti-oxidative, antiulcer, anticancer, and anti-inflammatory properties (Kraan, 2012 ; Misurcova et al, 2015 ; de Jesus Raposo et al, 2015 ). Cyanobacteria and algae have been suggested to synthesize polysaccharides and the polysaccharides produced by microalgae ranges from ~0.5 g/L up to 20 g/L (Markou and Nerantzis, 2013 ).…”

Section: An Outlook Of Metabolites: Basically What They Are?mentioning

confidence: 99%

Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects

et al. 2017

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Cyanobacteria and algae having complex photosynthetic systems can channelize absorbed solar energy into other forms of energy for production of food and metabolites. In addition, they are promising biocatalysts and can be used in the field of “white biotechnology” for enhancing the sustainable production of food, metabolites, and green energy sources such as biodiesel. In this review, an endeavor has been made to uncover the significance of various metabolites like phenolics, phytoene/terpenoids, phytols, sterols, free fatty acids, photoprotective compounds (MAAs, scytonemin, carotenoids, polysaccharides, halogenated compounds, etc.), phytohormones, cyanotoxins, biocides (algaecides, herbicides, and insecticides) etc. Apart from this, the importance of these metabolites as antibiotics, immunosuppressant, anticancer, antiviral, anti-inflammatory agent has also been discussed. Metabolites obtained from cyanobacteria and algae have several biotechnological, industrial, pharmaceutical, and cosmetic uses which have also been discussed in this review along with the emerging technology of their harvesting for enhancing the production of compounds like bioethanol, biofuel etc. at commercial level. In later sections, we have discussed genetically modified organisms and metabolite production from them. We have also briefly discussed the concept of bioprocessing highlighting the functioning of companies engaged in metabolites production as well as their cost effectiveness and challenges that are being addressed by these companies.

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Section: An Outlook Of Metabolites: Basically What They Are?mentioning

confidence: 99%

Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects

et al. 2017

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“…Polysaccharides are generally used as stabilization or thickening agents for emulsions. In some cases, they are used as bioactive compounds owing to their antitumor, antiviral, antibacterial, anti-inflammatory, and immunostimulatory properties [92][93][94][95]. Toyocamycin and tubercidin are both anti-fungal nucleoside chemicals isolated from Tolypothrix tenuis [96].…”

Section: Lipids/saccharides/nucleosides/othersmentioning

confidence: 99%

Current Status and Future Strategies to Increase Secondary Metabolite Production from Cyanobacteria

et al. 2020

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Cyanobacteria, given their ability to produce various secondary metabolites utilizing solar energy and carbon dioxide, are a potential platform for sustainable production of biochemicals. Until now, conventional metabolic engineering approaches have been applied to various cyanobacterial species for enhanced production of industrially valued compounds, including secondary metabolites and non-natural biochemicals. However, the shortage of understanding of cyanobacterial metabolic and regulatory networks for atmospheric carbon fixation to biochemical production and the lack of available engineering tools limit the potential of cyanobacteria for industrial applications. Recently, to overcome the limitations, synthetic biology tools and systems biology approaches such as genome-scale modeling based on diverse omics data have been applied to cyanobacteria. This review covers the synthetic and systems biology approaches for advanced metabolic engineering of cyanobacteria.

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“…Alginates is another compound in marine algae. Alginates without sulfate groups are constituents located in the cell wall and in the matrix of brown (Mišurcová et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

The Potential of Cytotoxin and Antiviral in Sargassum polycystum and Sargassum ilicifolium’s Polysaccharides Extract

et al. 2020

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Marine algae known as one producers of bioactive compounds. This study aims to analyze the cytotoxicity and antiviral activity in Sargassum polycystum and Sargassum ilicifolium tested with Herpes Simplex Virus (HSV). The polysaccharides extract of algae was used in this study, as sulfated polysaccharides have been reported has bioactivity. Cytotoxicity either antiviral could be correlated with the sulfate content as well as nature and chemical composition of the polysaccharides. Cytotoxicity and antiviral analysis based upon cell viability. Using the Vero cell / HSV-1 model, cytotoxicity was evaluated by incubating cellular suspensions (3.5×105 cells.mL-1) with various dilutions (concentration from 1 to 500 µg.mL-1, four wells per concentration) of fractions in 96-well plates (72h, 37°C, 5% CO2) in Eagle's MEM containing 8% FCS. The cells were examined daily under a phase-contrast microscope to determine the minimum concentration of hydrolysate dry matter that induced alterations in cell morphology, including swelling, shrinkage, granularity and detachment. Algae S. illicifolium was found to have the highest cytotoxic content in each solution compared to S. polycystum. Algae S. illicifolium in KOH 4M (cellulose) reached 2,707 µg.ml-1, then HCl pH 2 (fucoidan) was 2,477 µg.ml-1, then CaCl2 2% (fucoidan) was 2,362 µg.ml-1, and in Na2CO3 3% (alginates) was 2,134 µg.ml-1. For antiviral, S. polycystum contained the highest antiviral compounds compared to S. illicifolium with KOH 4M (cellulose) solution was reached 67.02 µg.ml-1. Then in Na2CO3 3% (alginates) which was 33.25 µg.ml-1, then CaCl2 2% (fucoidan) which was 31.62 µg.ml-1,and HCl pH 2 (fucoidan) was 30.08 µg.ml-1. After all, the highest bioactivity compounds was found with KOH 4M (cellulose) for cytotoxicity in S. ilicifolium and antiviral activity in S. polycystum.

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Algal Polysaccharides and Health

Cited by 16 publications

References 126 publications

Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects

Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects

Current Status and Future Strategies to Increase Secondary Metabolite Production from Cyanobacteria

The Potential of Cytotoxin and Antiviral in Sargassum polycystum and Sargassum ilicifolium’s Polysaccharides Extract

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