Algal toxins and producers in the marine waters of Qatar, Arabian Gulf

Muftah, Abdulrahman Al; Selwood, Andrew I.; Foss, Amanda J.; Jabri, Hareb Al; Potts, Malcolm; Yılmaz, Mete

doi:10.1016/j.toxicon.2016.09.016

Cited by 30 publications

(16 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only one species of this genus has been described, but, in sight of both the genetic and toxin profiles, it has been suggested that V. rugosum could be a species complex [26]. Some strains of V. rugosum produce mainly PnTX G, like those from Mediterranean France (the area from which the species was described) [6], as well as a strain isolated from Japan [18], but some other strains do not produce PnTX G, for instance, most isolates from New Zealand and Australia produce mainly PnTX F [13] and most from China and Qatar produce PnTX H [27,28,29]. The toxin profiles obtained in this work would support the possibility of the Mediterranean strain as the source of toxins.…”

Section: Discussionmentioning

confidence: 99%

Detection and Spatio-Temporal Distribution of Pinnatoxins in Shellfish from the Atlantic and Cantabrian Coasts of Spain

Lamas

Arévalo

Moroño

et al. 2019

Toxins

View full text Add to dashboard Cite

For the first time, pinnatoxins have been detected in shellfish from the Atlantic and Cantabrian coasts of Spain. High sensitivity LC-MS/MS systems were used to monitor all the currently known pinnatoxins (A–H). Pinnatoxin G (PnTX G) was the most prevalent toxin of the group, but its metabolite PnTX A has also been found at much lower levels. No trend in PnTX G concentration was found in the area, but a hotspot in the Ría de Camariñas has been identified. The maximum concentrations found did not exceed 15 µg·kg−1, being, in most cases, below 3 µg·kg−1. The highest concentrations were found in wild (intertidal) populations of mussels which attained much higher levels than raft-cultured ones, suggesting that the toxin-producer organisms preferentially develop in shallow areas. Other bivalve species had, in general, lower concentrations. The incidence of PnTX G followed a seasonal pattern in which the maximum concentrations took place in winter months. PnTX G was found to be partially esterified but the esterification percentage was not high (lower than 30%).

show abstract

Section: Discussionmentioning

confidence: 99%

Detection and Spatio-Temporal Distribution of Pinnatoxins in Shellfish from the Atlantic and Cantabrian Coasts of Spain

Lamas

Arévalo

Moroño

et al. 2019

Toxins

View full text Add to dashboard Cite

show abstract

“…) and in the marine waters of Qatar, Arabian Gulf (Al Muftah et al . ). Vulcanodinium rugosum strains of various origins have been reported to produce not only different pinnatoxins, but also to differ from each other in partial large subunit rDNA, internal transcribed spacer regions, and 5.8S rDNA sequences (Rhodes et al .…”

Section: Dinoflagellate Species Involved In the Production Of Cyclic mentioning

confidence: 97%

Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors

Molgó

Marchot

Aráoz

et al. 2017

Journal of Neurochemistry

View full text Add to dashboard Cite

We present an overview of the toxicological profile of the fast acting, lipophilic macrocyclic imine toxins, an emerging family of organic compounds associated with algal blooms, shellfish contamination and neurotoxicity. Worldwide, shellfish contamination incidents are expanding; therefore the significance of these toxins for the shellfish food industry deserves further study. Emphasis is directed to the dinoflagellate species involved in their production, their chemical structures, and their specific mode of interaction with their principal natural molecular targets, the nicotinic acetylcholine receptors, or with the soluble acetylcholine-binding protein, used as a surrogate receptor model. The dinoflagellates Karenia selliformis and Alexandrium ostenfeldii / A. peruvianum have been implicated in the biosynthesis of gymnodimines and spirolides, while Vulcanodinium rugosum is the producer of pinnatoxins and portimine. The cyclic imine toxins are characterized by a macrocyclic skeleton comprising 14 to 27 carbon atoms, flanked by two conserved moieties, the cyclic imine and the spiroketal ring system. These phycotoxins generally display high affinity and broad specificity for the muscle-type and neuronal nicotinic acetylcholine receptors, a feature consistent with their binding site at the receptor subunit interfaces, composed of residues highly conserved among all nAChRs, and explaining the diverse toxicity among animal species.

show abstract

“…Today, eight GYM analogues have been identified ( Figure 1) [28]. Besides the New Zealand episodes, GYMs have also been reported in many other countries (Table S1; Figure 2) [21,24,[35][36][37][38][39][40]. Recently, it was demonstrated that the A. ostenfeldii and A. peruvianum possessed the ability to produce not only SPXs, but also GYMs [24,41,42].…”

Section: Introductionmentioning

confidence: 98%

Cyclic Imines (CIs) in Mussels from North-Central Adriatic Sea: First Evidence of Gymnodimine A in Italy

Bacchiocchi

Siracusa

Campacci

et al. 2020

Toxins

View full text Add to dashboard Cite

Cyclic imines (CIs) are emerging marine lipophilic toxins (MLTs) occurring in microalgae and shellfish worldwide. The present research aimed to study CIs in mussels farmed in the Adriatic Sea (Italy) during the period 2014–2015. Twenty-eight different compounds belonging to spirolides (SPXs), gymnodimines (GYMs), pinnatoxins (PnTXs) and pteriatoxins (PtTXs) were analyzed by the official method for MLTs in 139 mussel samples collected along the Marche coast. Compounds including 13-desmethyl spirolide C (13-desMe SPX C) and 13,19-didesmethyl spirolide C (13,19-didesMe SPX C) were detected in 86% of the samples. The highest levels were generally reported in the first half of the year reaching 29.2 µg kg−1 in January/March with a decreasing trend until June. GYM A, for the first time reported in Italian mussels, was found in 84% of the samples, reaching the highest concentration in summer (12.1 µg kg−1). GYM A and SPXs, submitted to tissue distribution studies, showed the tendency to accumulate mostly in mussel digestive glands. Even if SPX levels in mussels were largely below the European Food Safety Authority (EFSA) reference of 400 μg SPXs kg−1, most of the samples contained CIs for the large part of the year. Since chronic toxicity data are still missing, monitoring is surely recommended.

show abstract

Algal toxins and producers in the marine waters of Qatar, Arabian Gulf

Cited by 30 publications

References 76 publications

Detection and Spatio-Temporal Distribution of Pinnatoxins in Shellfish from the Atlantic and Cantabrian Coasts of Spain

Detection and Spatio-Temporal Distribution of Pinnatoxins in Shellfish from the Atlantic and Cantabrian Coasts of Spain

Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors

Cyclic Imines (CIs) in Mussels from North-Central Adriatic Sea: First Evidence of Gymnodimine A in Italy

Contact Info

Product

Resources

About