Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine

Farshidfar, Nima; Iravani, Siavash; Varma, Rajender S.

doi:10.3390/md21030189

Cited by 68 publications

(14 citation statements)

References 102 publications

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“…The fact that the developed material in this study supports the attachment of the cells is valuable. This characteristic is the Achilles heel of many biomaterials, both synthetic and natural, even those that are widely used in research, such as polydimethylsiloxane, aliphatic polyesters, poly(vinyl alcohol), or even biopolymers such as alginate, chitosan, and bacterial cellulose . As a result, in these cases, additional efforts are required to confer cell affinity to the material, for example, through blending, conjugation of CAP to molecule, or surface modification .…”

Section: Results and Discussionmentioning

confidence: 99%

Multifunctional Casein-Based Wound Dressing Capable of Monitoring and Moderating the Proteolytic Activity of Chronic Wounds

Kolahreez,

Ghasemi-Mobarakeh,

Quartinello

et al. 2024

Biomacromolecules

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Every 1.2 s, a diabetic foot ulcer is developed, and every 20 s, one amputation is carried out in diabetic patients. Monitoring and controlling protease activity have been considered as a strategy for more efficient management of diabetic and other chronic wounds. This study aimed to develop a casein-based dressing that, by its disappearance, provides information about the activity of proteases and simultaneously harnesses proteolytic activity. Casein films were fabricated by using an aqueous solution, and heat treatment was successfully deployed as a green and clean approach to confer hydrolytic stability. Our results showed that casein-based films' mechanical characteristics, water absorption, and proteolytic stability could be controlled by the length of the heat treatment, which proved to be a useful tool. An increase in the treatment duration from 30 min to 3 h led to toleration of 2.4 times higher stress, 2 times lower water uptake, and 3.4 times higher proteolytic stability at examined conditions. Selected casein-based structures responded to Bacillus sp. bacteria's protease (BSP) and human neutrophil elastase (HNE) as representatives of bacterial and nonbacterial proteases found in the wounds at 10 and 200 ng mL −1 levels, respectively. The hydrolysis was accompanied by a 36% reduction in proteolytic activity measured by using a caseinbased universal protease activity assay. The released casein fragments could scavenge 90% of the examined radicals. In-vitro cell culture studies showed that the hydrolysates were not cytotoxic, and the casein-based film had a favorable interaction with fibroblast cells, indicating its potential as a scaffold in the case that proteolytic activity would not be to the extent that causes its rapid disintegration. In general, these findings hold promise for applying the developed casein-based structure for detecting proteolytic activity without the need for any equipment, kits, or expertise and, more importantly, in a highly economical manner. In the case that the proteolytic activity would not be severe, it could also serve as a substrate for cell adhesion and growth; this would aid in the healing process.

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Section: Results and Discussionmentioning

confidence: 99%

Multifunctional Casein-Based Wound Dressing Capable of Monitoring and Moderating the Proteolytic Activity of Chronic Wounds

Kolahreez,

Ghasemi-Mobarakeh,

Quartinello

et al. 2024

Biomacromolecules

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“…Alginates are naturally occurring polysaccharide-polyanions that possess high biocompatibility and biodegradability. With their non-toxic and highly hydrophilic properties, alginates can fit into several cost-compliant biotechnological applications [48,49]. Alginatebased biomaterials fit into the mold of cell-homing materials utilized for bone-tissue engineering and regenerative medicine [50].…”

Section: Alginatesmentioning

confidence: 99%

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

Banerjee

Madhyastha

2023

JNT

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Nanomaterial-based tissue engineering strategies are precisely designed and tweaked to contest specific patient needs and their end applications. Though theragnostic is a radical term very eminent in cancer prognosis, of late, theragnostic approaches have been explored in the fields of tissue remodulation and reparation. The engineering of theragnostic nanomaterials has opened up avenues for disease diagnosis, imaging, and therapeutic treatments. The instantaneous monitoring of therapeutic strategy is expected to co-deliver imaging and pharmaceutical agents at the same time, and nanoscale carrier moieties are convenient and efficient platforms in theragnostic applications, especially in soft and hard tissue regeneration. Furthermore, imaging modalities have extensively contributed to the signal-to-noise ratio. Simultaneously, there is an accumulation of high concentrations of therapeutic mediators at the defect site. Given the confines of contemporary bone diagnostic systems, the clinical rationale demands nano/biomaterials that can localize to bone-diseased sites to enhance the precision and prognostic value for osteoporosis, non-healing fractures, and/or infections, etc. Furthermore, bone theragnostics may have an even greater clinical impact and multimodal imaging procedures can overcome the restrictions of individual modalities. The present review introduces representative theragnostic polymeric nanomaterials and their advantages and disadvantages in practical use as well as their unique properties.

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“…Alginate (SA), a polysaccharide extracted from brown seaweed, is nowadays utilized increasingly as a carrier to transport active compounds and in the production of hydrogels due to its biodegradability, nontoxicity, low cost, and ease of gelation [32,33]. Also, SA has film-forming properties and produces impermeable films to oils and lipids [34].…”

Section: Introductionmentioning

confidence: 99%

Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

Rusu,

Niță,

Roșca

et al. 2023

Pharmaceutics

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Owing to its antibacterial, anti-inflammatory, and antioxidant activities, in the last few years, lavender essential oil (LVO) has been used in medical applications as a promising approach for treating infected wounds. However, the practical applicability of LVO is limited by its high volatility and storage stability. This study aimed to develop a novel hybrid hydrogel by combining phytic acid (PA)-crosslinked sodium alginate (SA) and poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5] undecane (PITAU) and evaluate its potential effectiveness as an antibacterial wound dressing after incorporating LVO. The influence of the mass ratio between SA and PITAU on the properties and stability of hydrogels was investigated. After LVO loading, the effect of oil addition to hydrogels on their functional properties and associated structural changes was studied. FTIR analysis revealed that hydrogen bonding is the primary interaction mechanism between components in the hybrid hydrogels. The morphology was analyzed using SEM, evidencing a porosity dependent on the ratio between SA and PITAU, while LVO droplets were well dispersed in the polymer blend. The release of LVO from the hydrogels was determined using UV-VIS spectroscopy, indicating a sustained release over time, independent of the LVO concentration. In addition, the hybrid hydrogels were tested for their antioxidant properties and antimicrobial activity against Gram-positive and Gram-negative bacteria. Very good antimicrobial activity was obtained in the case of sample SA_PITAU3+LVO10% against S. aureus and C. albicans. Moreover, in vivo tests showed an increased antioxidant effect of the SA_PITAU3+LVO10% hydrogel compared to the oil-free scaffold that may aid in accelerating the healing process of wounds.

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Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine

Cited by 68 publications

References 102 publications

Multifunctional Casein-Based Wound Dressing Capable of Monitoring and Moderating the Proteolytic Activity of Chronic Wounds

Multifunctional Casein-Based Wound Dressing Capable of Monitoring and Moderating the Proteolytic Activity of Chronic Wounds

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

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