Alginate-based interpenetrating polymer networks for sustained drug release

Hasnain, Saquib; Ray, Priyanka; Nayak, Amit Kumar

doi:10.1016/b978-0-12-817640-5.00005-4

“…Sodium alginate is a linear anionic polysaccharide, composed by B-D mannuronic acid and a-L-guluronic acid units, obtained mainly from brown marine algae [8,9]. Due to its properties (biocompatible, biodegradable and non-toxic) several materials have been developed from alginate such as microparticles, hydrogels and films for applications in biomedical field [10]. Specifically, sodium alginate hydrogels have a similar structure to natural extracellular matrix, and for that reason their use in tissue engineering and drug delivery has grown exponentially [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Due to its properties (biocompatible, biodegradable and non-toxic) several materials have been developed from alginate such as microparticles, hydrogels and films for applications in biomedical field [10]. Specifically, sodium alginate hydrogels have a similar structure to natural extracellular matrix, and for that reason their use in tissue engineering and drug delivery has grown exponentially [10,11]. Previous studies in the field of cartilage tissue engineering have shown that its application does not produce synovitis or degenerative cartilage changes, promote adhesion and proliferation of chondrocytes to increase the deposition of glycosaminoglycans and aggrecans in the matrix, increasing the articular cartilage restoration [9].…”

Section: Introductionmentioning

confidence: 99%

“…Among the synthetic polymers poly(2-hydroxyethyl methacrylate) (HEMA), a neutral hydrophilic polymer, has been one of most used in tissue engineering due to its versatile properties such as biocompatibility, good mechanical properties, and ease of synthesis [4,5,12]. Hydrogels for cartilage tissue engineering from the combination of polymers, natural (eg chitosan, collagen) and synthetic (polyethylene glycol and polyvinyl alcohol) have been reported by several authors [4,10,13]. 2-acryloyloxyethyl trimethyl ammonium chloride (QCL) is a positive charged monomer composed by a polymerizable double bond and a quaternary ammonium at the end of its structure.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

García-Couce¹,

Vernhes²,

Bada³

et al. 2021

Preprint

3

0

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Hydrogels obtained from the combination of different polymers are an interesting strategy for the development of controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using different concentration of the components. The hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and swelling degree; betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay shown that almost all hydrogels are cytocompatibles and an increase the proliferation in both cell types after one week of incubation was observed by Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics and biocompatibility.

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“…Sodium alginate (AlgNa) is a linear anionic polysaccharide, composed by β-D mannuronic acid and α-L-guluronic acid units, obtained mainly from brown marine algae [8,9]. Due to its properties (biocompatible, biodegradable and non-toxic) several materials have been developed from alginate such as microparticles, hydrogels and films for applications in biomedical field [10]. Specifically, sodium alginate hydrogels have a similar structure to natural extracellular matrix, and for that reason their use in tissue engineering and drug delivery has grown exponentially [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Hydrogels for cartilage tissue engineering from the combination of polymers, natural (eg chitosan, collagen) and synthetic (polyethylene glycol and polyvinyl alcohol) have been reported by several authors [4,10,13]. 2-acryloyloxyethyl trimethyl ammonium chloride (QCL) is a positive charged monomer composed by a polymerizable double bond and a quaternary ammonium at the end of its structure.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

García-Couce¹,

Vernhes²,

Bada³

et al. 2021

Preprint

4

0

View full text Add to dashboard Cite

Hydrogels obtained from the combination of different polymers are an interesting strategy for the development of controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using different concentration of the components. The hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and swelling degree; betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay shown that almost all hydrogels are cytocompatibles and an increase the proliferation in both cell types after one week of incubation was observed by Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics and biocompatibility.

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Nano‐curcumin/graphene platelets loaded on sodium alginate/polyvinyl alcohol fibers as potential wound dressing

Rezaei

¹

,

Nikkhah

²

,

Mohammadi

³

et al. 2021

J of Applied Polymer Sci

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Innovative composites of biopolymers and nanomaterials have been exploited to fabricate wound dressings which show functional abilities to improve different stages of wound healing by a variety of mechanisms. In this study, a polymeric nanocomposite dressing is fabricated by electrospinning of a blend of sodium alginate (SA), poly vinyl alcohol (PVA) and graphene nanoplatelets (Gnp). The crosslinking of the nanofibers is done by thermal treatment followed by ionic bonding of the fibers. The crosslinked fibers are loaded by curcumin, a natural potent anti‐inflammatory compound, encapsulated in monomethoxy poly ethylene glycol‐oleate micelles/polymersomes (NCur). Results indicate that by incorporation of Gnp and NCur into the SA/PVA scaffold the tensile strength is not changed (~7 MPa) but the elongation to break and toughness of the scaffolds significantly increase from 11.25±2.6 and 50.56 to 35.5±5.1% and 125.9 Jm‐3, respectively. The scaffolds support the controlled release of curcumin for 24 h in vitro. Biocompatibility of the scaffolds has been confirmed by cell viability assay on mouse fibroblast cells. Overall, the findings demonstrate the potential applications of the spun fibers for wound dressing purposes.

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Alginate-based interpenetrating polymer networks for sustained drug release

Cited by 11 publications

References 106 publications

Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

Nano‐curcumin/graphene platelets loaded on sodium alginate/polyvinyl alcohol fibers as potential wound dressing

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