Alginate Based Micro Particulate Systems for Drug Delivery

Doniparthi, Jyosna; Bhargav, E.

doi:10.1007/978-981-19-6937-9_2

Cited by 2 publications

(1 citation statement)

References 121 publications

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“…Although alginate hydrogel microbeads may expand under physiological conditions, they are frequently solid and slow to break down [124], rendering them unsuitable for regulated therapeutic drug release in the gastrointestinal tract. Alginate hydrogel microbeads may expand under physiological conditions, and we have hypothesized that alginate microbeads containing basic functional groups will behave differently than those containing acidic functional groups when exposed to acidic or basic solutions [125][126][127][128]. As a consequence, modifying the release rate may be accomplished by elevating the alginate polymer capacity for swelling and/or its water-soluble properties at a certain pH.…”

Section: Alginate Derivativesmentioning

confidence: 99%

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

Harun-Or-Rashid,

Aktar,

Hossain

et al. 2023

Polymers

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Polymeric drug delivery technology, which allows for medicinal ingredients to enter a cell more easily, has advanced considerably in recent decades. Innovative medication delivery strategies use biodegradable and bio-reducible polymers, and progress in the field has been accelerated by future possible research applications. Natural polymers utilized in polymeric drug delivery systems include arginine, chitosan, dextrin, polysaccharides, poly(glycolic acid), poly(lactic acid), and hyaluronic acid. Additionally, poly(2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide), poly(ethylenimine), dendritic polymers, biodegradable polymers, and bioabsorbable polymers as well as biomimetic and bio-related polymeric systems and drug-free macromolecular therapies have been employed in polymeric drug delivery. Different synthetic and natural biomaterials are in the clinical phase to mitigate different diseases. Drug delivery methods using natural and synthetic polymers are becoming increasingly common in the pharmaceutical industry, with biocompatible and bio-related copolymers and dendrimers having helped cure cancer as drug delivery systems. This review discusses all the above components and how, by combining synthetic and biological approaches, micro- and nano-drug delivery systems can result in revolutionary polymeric drug and gene delivery devices.

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