Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

Sánchez, Encarnación Cruz; García, María Teresa; Pereira, Joana; Oliveira, Filipe S.; Craveiro, Rita; Paiva, Alexandre; Gracia, Ignacio; García-Vargas, Jesús Manuel; Duarte, Ana Rita C.

doi:10.3390/molecules28093689

Cited by 11 publications

(9 citation statements)

References 44 publications

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“…Most of the bands characteristic to the main components of LVO such as linalool, linalyl acetate, lavandulyl acetate, 1,8-cineol, and β-caryophyllene overlap with the bands from the polymeric matrix constituents. These results are consistent with other published work [63]. Based on the above observations, it can be concluded that the hydrogel effectively incorporates LVO.…”

Section: Ftir Analysissupporting

confidence: 93%

“…Given its antibacterial properties, it could be hypothesized that by releasing a large amount of LVO within the initial 24 h, bacterial infection significantly decreases. It may also lead to a reduction in the pain associated with injuries, as LVO has been reported to possess analgesic activity [63]. Later, a steady concentration of oil at the wound site aids in healing and providing antibacterial cover, as observed by other authors [68].…”

Section: Lvd Loading/release Studiesmentioning

confidence: 86%

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Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

Rusu,

Niță,

Roșca

et al. 2023

Pharmaceutics

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Owing to its antibacterial, anti-inflammatory, and antioxidant activities, in the last few years, lavender essential oil (LVO) has been used in medical applications as a promising approach for treating infected wounds. However, the practical applicability of LVO is limited by its high volatility and storage stability. This study aimed to develop a novel hybrid hydrogel by combining phytic acid (PA)-crosslinked sodium alginate (SA) and poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5] undecane (PITAU) and evaluate its potential effectiveness as an antibacterial wound dressing after incorporating LVO. The influence of the mass ratio between SA and PITAU on the properties and stability of hydrogels was investigated. After LVO loading, the effect of oil addition to hydrogels on their functional properties and associated structural changes was studied. FTIR analysis revealed that hydrogen bonding is the primary interaction mechanism between components in the hybrid hydrogels. The morphology was analyzed using SEM, evidencing a porosity dependent on the ratio between SA and PITAU, while LVO droplets were well dispersed in the polymer blend. The release of LVO from the hydrogels was determined using UV-VIS spectroscopy, indicating a sustained release over time, independent of the LVO concentration. In addition, the hybrid hydrogels were tested for their antioxidant properties and antimicrobial activity against Gram-positive and Gram-negative bacteria. Very good antimicrobial activity was obtained in the case of sample SA_PITAU3+LVO10% against S. aureus and C. albicans. Moreover, in vivo tests showed an increased antioxidant effect of the SA_PITAU3+LVO10% hydrogel compared to the oil-free scaffold that may aid in accelerating the healing process of wounds.

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Section: Ftir Analysissupporting

confidence: 93%

Section: Lvd Loading/release Studiesmentioning

confidence: 86%

Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

Rusu,

Niță,

Roșca

et al. 2023

Pharmaceutics

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“…In a study regarding the production and characterization of chitosan films with tea tree oil [ 75 ], the authors showed that their formulations had fluid absorption and blood clotting abilities, which are important characteristics in a wound dressing. Several studies also report that polymeric films incorporated with PEs and EOs can promote fibroblast [ 71 , 75 , 82 , 85 ] and keratinocyte [ 86 ] proliferation, maintaining their viability. Furthermore, films with PEs and EOs can promote fibroblast migration [ 82 , 85 , 87 ], enhancing the wound healing process.…”

Section: Formulations Incorporated With Eos and Pesmentioning

confidence: 99%

“…The authors in [ 71 ] produced chitosan films with Hypericum perforatum EOs and verified that these formulations were good surfaces for cell attachment. Moreover, various studies mention that films with EOs and PEs are biocompatible [ 78 , 82 , 83 , 86 , 87 ], presenting low cytotoxicity [ 79 ].…”

Section: Formulations Incorporated With Eos and Pesmentioning

confidence: 99%

Plant-Based Films and Hydrogels for Wound Healing

Lopes,

Pintado,

Tavaria

2024

Microorganisms

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Skin is constantly exposed to injury and infectious agents that can compromise its structural integrity and cause wounds. When this occurs, microorganisms from the skin microbiota and external bacteria and fungi can penetrate the wound and cause an infection, which complicates the healing process. Nowadays, there are several types of wound dressings available to treat wounds, some of which are incorporated with antimicrobial agents. However, the number of microorganisms resistant to these substances is rising. Therefore, the search for new, natural alternatives such as essential oils (EOs) and plant extracts (PEs) is on the rise. However, these substances present some limitations (poor bioavailability and poor target capacity), which limits their efficiency. Their incorporation in formulations in the form of films and hydrogels (HGs) can help to overcome these issues and may be a potential alternative to the current treatments. HGs and films incorporated with PEs and EOs have antimicrobial activity, promote the viability of skin cells and fibroblast migration, and are non-toxic and biocompatible. This review discusses the use of films and HGs for the topical delivery of EOs and PEs for wound treatment and their formulations as effective wound dressings, while debating some mechanisms and biological properties to elucidate their presumptive clinical relevance and possible applications.

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“…Additionally, it was noted that both animal trials and human studies using Lav-O as a topical treatment for aphthous ulceration revealed a substantial decrease in ulcer size when compared to controls [ 22 ]. Besides, lavender essential oils have already been explained as a wound-healing agent due to their capacity to accelerate wound contraction [ 23 ]. .…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of a topical gel, containing lavender (Lavandula angustifolia) oil loaded solid lipid nanoparticles

Fahimnia,

Nemattalab,

Hesari

2024

BMC Complement Med Ther

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Gels loaded with nanocarriers offer interesting ways to create novel therapeutic approaches by fusing the benefits of gel and nanotechnology. Clinical studies indicate that lavender oil (Lav-O) has a positive impact on accelerating wound healing properly based on its antimicrobial and anti-inflammatory effects. Initially Lav-O loaded Solid Lipid Nanoparticles (Lav-SLN) were prepared incorporating cholesterol and lecithin natural lipids and prepared SLNs were characterized. Next, a 3% SLN containing topical gel (Lav-SLN-G) was formulated using Carbopol 940. Both Lav-SLN and Lav-SLN-G were assessed in terms antibacterial effects against S. aureus. Lav-SLNs revealed a particle size of 19.24 nm, zeta potential of -21.6 mv and EE% of 75.46%. Formulated topical gel presented an acceptable pH and texture properties. Minimum Inhibitory/Bactericidal Concentration (MIC/MBC) against S. aureus for LAv-O, Lav-SLN and Lav-SLN-G were 0.12 and 0.24 mgml− 1, 0.05 and 0.19 mgml− 1 and 0.045, 0.09 mgml− 1, respectively. Therefore, SLN can be considered as an antimicrobial potentiating nano-carrier for delivery of Lav-O as an antimicrobial and anti-inflammatory agent in topical gel.

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Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

Cited by 11 publications

References 44 publications

Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

Plant-Based Films and Hydrogels for Wound Healing

Development and characterization of a topical gel, containing lavender (Lavandula angustifolia) oil loaded solid lipid nanoparticles

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