Alginate controls heartburn in patients with erosive and nonerosive reflux disease

Savarino, Edoardo; Bortoli, Nicola de; Zentilin, Patrizia; Martinucci, Irene; Bruzzone, Luca; Furnari, Manuele; Marchi, Santino; Savarino, Vincenzo

doi:10.3748/wjg.v18.i32.4371

Cited by 65 publications

(63 citation statements)

References 54 publications

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“…However, the poor sensitivity and specificity of all currently available diagnostic tests for LPR has been highlighted by several review articles [Altman et al 2011;Katz et al 2013;Vaezi et al 2003]. In a population of patients with laryngoscopic findings of LPR, our group showed that MII-pH confirmed GERD diagnosis in less than 40% of patients [de Bortoli et al 2012], thus highlighting the critical issue of nonspecific symptoms and laryngoscopic findings of LPR [Zerbib and Stoll, 2010]. New promising diagnostic techniques have been developed for extraesophageal reflux syndromes, in particular, an immunologic pepsin assay (Peptest TM ), which has been shown to be a rapid, sensitive, and specific tool [Bardhan et al 2012;Samuels and Johnston, 2010], and a new pH pharyngeal catheter (manufactured by Restech, San Diego, CA, USA) that recent study documented as highly sensitive and minimally invasive device for the detection of liquid or vapors of acid reflux in the posterior oropharynx [Sun et al 2009].…”

Section: Optimal Treatment Of Laryngopharyngeal Reflux Diseasementioning

confidence: 87%

Optimal treatment of laryngopharyngeal reflux disease

Martinucci

Bortoli

Savarino

et al. 2013

Therapeutic Advances in Chronic Disease

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Laryngopharyngeal reflux is defined as the reflux of gastric content into larynx and pharynx. A large number of data suggest the growing prevalence of laryngopharyngeal symptoms in patients with gastroesophageal reflux disease. However, laryngopharyngeal reflux is a multifactorial syndrome and gastroesophageal reflux disease is not the only cause involved in its pathogenesis. Current critical issues in diagnosing laryngopharyngeal reflux are many nonspecific laryngeal symptoms and signs, and poor sensitivity and specificity of all currently available diagnostic tests. Although it is a pragmatic clinical strategy to start with empiric trials of proton pump inhibitors, many patients with suspected laryngopharyngeal reflux have persistent symptoms despite maximal acid suppression therapy. Overall, there are scant conflicting results to assess the effect of reflux treatments (including dietary and lifestyle modification, medical treatment, antireflux surgery) on laryngopharyngeal reflux. The present review is aimed at critically discussing the current treatment options in patients with laryngopharyngeal reflux, and provides a perspective on the development of new therapies.

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Section: Optimal Treatment Of Laryngopharyngeal Reflux Diseasementioning

confidence: 87%

Optimal treatment of laryngopharyngeal reflux disease

Martinucci

Bortoli

Savarino

et al. 2013

Therapeutic Advances in Chronic Disease

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“…Patients were only allowed to take alginates, on as-needed basis, as rescue therapy for controlling typical GERD symptoms. 16 Patients who completed the MII-pH study received a double dose of PPI (Esomeprazole 40 mg b.d.) for at least 6 weeks (range 6-8) and, thereafter, the Fisman Cough Severity/Frequency Scores were re-assessed.…”

Section: Methodsmentioning

confidence: 99%

Reflux pattern and role of impedance‐pH variables in predicting PPI response in patients with suspected GERD‐related chronic cough

Ribolsi

Savarino

Bortoli

et al. 2014

Aliment Pharmacol Ther

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“…Finally, some interesting studies, performed by means of MII-pH analysis, evaluated the effectiveness of raft-forming gel formulation in "add-on" treatment for GERD symptoms. These studies have clearly demonstrated the efficacy of raft-forming gel preparation in reducing the total number of refluxes and their proximal migration [90][91][92] .…”

Section: Multichannel Intraluminal Impedance and Phmentioning

confidence: 99%

Esophageal testing: What we have so far

Bortoli¹,

Martinucci²,

Bertani³

et al. 2016

WJGP

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Gastroesophageal reflux disease (GERD) is a common disorder of the gastrointestinal tract. In the last few decades, new technologies have evolved and have been applied to the functional study of the esophagus, allowing for the improvement of our knowledge of the pathophysiology of GERD. High-resolution manometry (HRM) permits greater understanding of the function of the esophagogastric junction and the risks associated with hiatal hernia. Moreover, HRM has been found to be more reproducible and sensitive than conventional water-perfused manometry to detect the presence of transient lower esophageal sphincter relaxation. Esophageal 24-h pH-metry with or without combined impedance is usually performed in patients with negative endoscopy and reflux symptoms who have a poor response to anti-reflux medical therapy to assess esophageal acid exposure and symptom-reflux correlations. In particular, esophageal 24-h impedance and pH monitoring can detect acid and non-acid reflux events. EndoFLIP is a recent technique poorly applied in clinical practice, although it provides a large amount of information about the esophagogastric junction. In the coming years, laryngopharyngeal symptoms could be evaluated with up and coming non-invasive or minimally invasive techniques, such as pepsin detection in saliva or pharyngeal pH-metry.

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Alginate controls heartburn in patients with erosive and nonerosive reflux disease

Abstract: Our findings demonstrate that Faringel is well-tolerated and effective in reducing heartburn by modifying esophageal acid exposure time, number of acid refluxes and their proximal migration.

Cited by 65 publications

References 54 publications

Optimal treatment of laryngopharyngeal reflux disease

Optimal treatment of laryngopharyngeal reflux disease

Reflux pattern and role of impedance‐pH variables in predicting PPI response in patients with suspected GERD‐related chronic cough

Esophageal testing: What we have so far

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