Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms

Yang, Shih-Hsien; Lin, Feng-Huei; Tsai, Hung Yin; Lin, Chia-Fu; Chin, Han-Chiang; Wong, Jau Min; Shieh, Ming‐Jium

doi:10.1016/j.biomaterials.2010.11.039

Cited by 104 publications

(63 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An alginate-complexed FA CS NP has been reported for photodynamic early detection of colorectal carcinoma. These NPs are readily engulfed by the cancer cells through FR-mediated endocytosis, furthermore an improved release in the cellular lysosome was observed when they are loaded with 5-aminolevulinic acid (5-ALA) [119].…”

Section: Folate Receptormentioning

confidence: 99%

Targeted Nanoparticles for Cancer Therapy

Blanco¹,

Teijón²,

Olmo³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

View full text Add to dashboard Cite

Section: Folate Receptormentioning

confidence: 99%

Targeted Nanoparticles for Cancer Therapy

Blanco¹,

Teijón²,

Olmo³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

View full text Add to dashboard Cite

“…Alginate-folic acid-modified chitosan nanoparticles were developed by a TPP cross-linking method for the photodynamic detection of intestinal neoplasm [128]. In another work, saponin-loaded chitosan-TPP nanoparticles were developed and showed increased toxicity toward cancer cells [129].…”

Section: Applications Of Modified Chitosan and Its Derivatives In Drumentioning

confidence: 99%

Approaches for Functional Modification or Cross‐Linking of Chitosan

Anitha

Rejinold

Bumgardner

et al. 2012

Chitosan‐Based Systems for Biopharmaceuticals

View full text Add to dashboard Cite

“…High-performance chitosan-based nanoparticles as carriers for 5-aminolevulinic acid (ALA) for oral cancer have been developed [90,91]. Serving as a prodrug, ALA is converted to the photosensitive fluorophore protoporphyrin IX in the cell mitochondria.…”

Section: Oral Cancermentioning

confidence: 99%

Advanced Drug Delivery Systems for Local Treatment of the Oral Cavity

2015

View full text Add to dashboard Cite

Good oral health is of major importance for general health and well-being. Several innovative drug delivery systems have been developed for the local treatment and prevention of various diseases in the oral cavity. However, there are currently few optimal systems and many therapeutic challenges still remain, including low drug efficacy and retention at targeted site of action. The present review provides an insight into the latest drug delivery strategies for the local treatment and prevention of the four most common oral pathologies, namely, dental caries, periodontitis, oral mucosal infections and oral cancer. The potential of bioadhesive formulations, nanoparticulate platforms, multifunctional systems and photodynamic methodologies to improve therapy and prophylaxis in future local applications for the oral cavity will be discussed.

show abstract

Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms

Cited by 104 publications

References 35 publications

Targeted Nanoparticles for Cancer Therapy

Targeted Nanoparticles for Cancer Therapy

Approaches for Functional Modification or Cross‐Linking of Chitosan

Advanced Drug Delivery Systems for Local Treatment of the Oral Cavity

Contact Info

Product

Resources

About