Alginate/hyaluronic acid-based systems as a new generation of wound dressings: A review

Zarei, Nazanin; Hassanzadeh-Tabrizi, S.A.

doi:10.1016/j.ijbiomac.2023.127249

Cited by 16 publications

(2 citation statements)

References 108 publications

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“…Similarly, in vivo studies have shown that calcium alginate scaffolds facilitate platelet and erythrocyte aggregation [67,74]. Alginate has been combined with other natural biopolymers such as gelatin [75], hyaluronic acid [76,77], and chitosan [78] to create composites tailored to promote healing. In a recent study, researchers formulated a blend of physically crosslinked sodium alginate and carboxymethyl cellulose film, aiming to enhance water retention, slow degradation, and improve mechanical strength.…”

Section: Structure-function Paradigm In Alginatementioning

confidence: 99%

Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing

Sharma,

Kishen

2024

Biomimetics

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Chronic wounds such as diabetic ulcers are a major complication in diabetes caused by hyperglycemia, prolonged inflammation, high oxidative stress, and bacterial bioburden. Bioactive biopolymers have been found to have a biological response in wound tissue microenvironments and are used for developing advanced tissue engineering strategies to enhance wound healing. These biopolymers possess innate bioactivity and are biodegradable, with favourable mechanical properties. However, their bioactivity is highly dependent on their structural properties, which need to be carefully considered while developing wound healing strategies. Biopolymers such as alginate, chitosan, hyaluronic acid, and collagen have previously been used in wound healing solutions but the modulation of structural/physico-chemical properties for differential bioactivity have not been the prime focus. Factors such as molecular weight, degree of polymerization, amino acid sequences, and hierarchical structures can have a spectrum of immunomodulatory, anti-bacterial, and anti-oxidant properties that could determine the fate of the wound. The current narrative review addresses the structure–function relationship in bioactive biopolymers for promoting healing in chronic wounds with emphasis on diabetic ulcers. This review highlights the need for characterization of the biopolymers under research while designing biomaterials to maximize the inherent bioactive potency for better tissue regeneration outcomes, especially in the context of diabetic ulcers.

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Section: Structure-function Paradigm In Alginatementioning

confidence: 99%

Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing

Sharma,

Kishen

2024

Biomimetics

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“…The skin is the largest organ of the human body, 1 which plays a vital role in isolating the external environment and maintaining the homeostasis of the internal environment. 2 Thus, skin damage and wound healing are everyday clinical activities in our daily lives. 3 Various commonly used commercial wound dressings, such as gauze, wound bandages, and hydrocolloids, 4 are applied for wound healing; most of these dressings could cover the damaged areas and prevent them from external invasion.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a core–shell nanofibrous wound dressing with an antioxidant effect on skin injury

Feng,

Tang,

Qiu

et al. 2024

J. Mater. Chem. B

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An Injectable, Self‐Healing, and Degradable Hydrogel With a Photothermal and Photodynamic Therapy Synergistic Antibacterial Response

Yang,

Lin,

Xiao

et al. 2024

ChemistrySelect

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Hydrogel dressings play an important role in the treatment of bacterial infection. In this study, carboxymethyl chitosan (CM‐CS) was cross‐linked with aldehyde polyglycol (DF‐PEG), and then polydopamine (pDA) and 5,10,15, 20‐tetrakis (4‐aminophenyl) porphyrin (TAPP) were grafted to prepare a CM‐CS/DF‐PEG/pDA/TAPP hydrogel (CDPT). The results showed that the CDPT hydrogel had good adhesion, injectability, self‐healing, degradability, and biocompatibility. Under near‐infrared irradiation, the CDPT hydrogel has excellent photothermal and photodynamic effects and can effectively inhibit activity of Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and antibiotic‐resistant, methicillin‐resistant Staphylococcus aureus (MRSA). In summary, CDPT hydrogel has potential applications as antibacterial material.

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Alginate/hyaluronic acid-based systems as a new generation of wound dressings: A review

Cited by 16 publications

References 108 publications

Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing

Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing

Fabrication of a core–shell nanofibrous wound dressing with an antioxidant effect on skin injury

An Injectable, Self‐Healing, and Degradable Hydrogel With a Photothermal and Photodynamic Therapy Synergistic Antibacterial Response

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