Alginate Microspheres: The Innovative Approaches to Production of the Microbeads/Micro-Particles

Abstract

Multiparticulate dosage form is pharmaceutical formulations where the active substance is in the form of a number of small independent subunit such as, granules, microparticle, beads, and microspheres. Multiparticulate drug delivery systems are specifically suitable for achieving delayed and sustained release oral formulations with a minimum risk of dose dumping, local irritation, systemic toxicity, and variation in rate of bioavailability as they are less dependent on gastrointestinal transit time and offers many advantages over unit particulate dosage forms. Microbeads are small, sphere shaped, systematically produced free-flowing properties, semi-spherical solid units. Microbeads are the agglomerates of about size ranging from 0.5 mm to 1.0 mm, obtained from various starting materials and utilizing different innovative techniques. A blend of multiparticulate can also be used to provide the desired drug release profile. These round shaped particles produced by mostly principle of atomization technique.Among various different innovative techniques Vibration technology, Electrostatic bead generator, Jetcutter technology, electrostatic forces, dropping method and a mechanical cutting device are few of many. In current article it describes about the total methods involved and their working principles with diagrams were clearly illustrated. Now a days sodium alginate beads were designed by these technologies mostly in relative to microencapsulation techniques.
 Keywords: Atomization, Vibrating technology, Jetcutter device, Electrostatic bead generator Dropping method and electro-spray technology

Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles: DOE Production Optimization and Drug Delivery

“…A modified KP model (KP T lag ) (Equation (5)) is more suited for swellable systems [ 43 , 44 ], where the lag time before drug release at the beginning of the release ( ) is accounted for [ 45 ]. T lag accounts for the time before drug release at the start of the release process [ 15 ]. With the Weibull model [ 42 , 45 ] (Equation (6)), a is a time scale parameter of the process and b is a shape parameter of the release.…”

“…Extrusion-based methods consist of droplet generation through a nozzle followed by its hardening in a bath. It is a method that has been used in several studies, since it can produce millimetric particles and microparticles with excellent production rates, reproducibility, and low production costs [ 13 , 14 , 15 ]. The detachment of the drop can be aided by different forces, including vibration [ 16 ], electric field, called coaxial electrospray [ 17 , 18 ], or air, denominated the coaxial airflow technique [ 16 , 19 , 20 ].…”

Gellan Gum/Alginate Microparticles As Drug Delivery Vehicles: Doe Production Optimization and Drug Delivery

“…A modified KP model (KP T lag ) (Equation ( 5)) is more suited for swellable systems [43,44], where the lag time before drug release at the beginning of the release (T lag ) is accounted for [45]. T lag accounts for the time before drug release at the start of the release process [15]. With the Weibull model [42,45] (Equation ( 6)), a is a time scale parameter of the process and b is a shape parameter of the release.…”