Algogenic substances and metabolic status in work-related Trapezius Myalgia: a multivariate explorative study

Gerdle, Björn; Kristiansen, Jesper; Larsson, Björn; Saltin, Bengt; Søgaard, Karen; Sjøgaard, Gisela

doi:10.1186/1471-2474-15-357

Cited by 16 publications

(11 citation statements)

References 87 publications

(130 reference statements)

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“…The association between TBF and neck pain in the present study indicates that muscle microcirculation and alternations in TBF may be involved in the pathogenesis of neck pain development, which is also consistent with previous studies (Gerdle et al 2014;Knardahl 2002;Larsson et al 2008;Larsson et al 1999;Näslund et al 2007;Rosendal et al 2004;Sjogaard et al 2010;Strøm et al 2009b;Thorud et al 2012). Strom et al (2009b) showed significant correlations between neck pain and TBF during computer work for both subjects with chronic neck and shoulder pain and a healthy reference group; however, the associations were in opposite directions in the two groups.…”

Section: Neck Pain and Trapezius Blood Flowsupporting

confidence: 92%

Discomfort glare and psychological stress during computer work: subjective responses and associations between neck pain and trapezius muscle blood flow

Mork

Falkenberg

Fostervold

et al. 2019

Int Arch Occup Environ Health

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Exposure to additional environmental stress during computer work, such as visual and psychological demands, is associated with increased eye and neck discomfort, altered moods, and reduced well-being. The aim of this study is to elucidate further how subjective responses in healthy, young females with normal binocular vision are affected by glare and psychological stress during computer work, and to investigate possible associations between trapezius muscle blood flow and neck pain development. Methods Forty-three females participated in a laboratory experiment with a within-subject design. Four ten-minute computer work conditions with exposure to different stressors were performed at an ergonomically optimal workstation, under the following series of conditions: no additional stress, visual stress (induced as direct glare from a large glare source), psychological stress, and combined visual and psychological stress. Before and immediately after each computer work condition, questionnaires regarding different visual and eye symptoms, neck and shoulder symptoms, positive and negative state moods, perceived task difficulty, and perceived ambient lighting were completed. Associations between neck pain and trapezius muscle blood flow were also investigated. Results Exposure to direct glare induced greater development of visual/eye symptoms and discomfort, while psychological stress exposure made participants feel more negative and stressed. The perception of work lighting during glare exposure was closely related to perceived stress, and associations between visual discomfort and eyestrain, and neck pain were observed in all conditions. Furthermore, participants with high trapezius muscle blood flow overall reported more neck pain, independent of exposure. Conclusions Exposure to visual and psychological stresses during computer work affects the development of symptoms and negative moods in healthy, young females with normal binocular vision, but in different ways. The results also demonstrate the complex interactions involved in symptom development and lighting appraisal during computer work. When optimizing computer workstations, the complexity of the field must be taken into account, and several factors, including visual conditions, must be considered carefully.

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Section: Neck Pain and Trapezius Blood Flowsupporting

confidence: 92%

Discomfort glare and psychological stress during computer work: subjective responses and associations between neck pain and trapezius muscle blood flow

Mork

Falkenberg

Fostervold

et al. 2019

Int Arch Occup Environ Health

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“…In office workers the painful muscles showed adverse functional, morphological, hormonal, as well as metabolic characteristics. 28 , 29 , 30 , 31 , 32 Metabolic muscular capacity increased 33 as demonstrated even at the gene level, 34 and muscle morphological recovery was documented using advanced immunohistochemical stainings for satellite cells 35 and neuronal nitric oxide synthase. 28 …”

Section: Resultsmentioning

confidence: 99%

Exercise is more than medicine: The working age population's well-being and productivity

Sjøgaard

Christensen

Justesen

et al. 2016

Journal of Sport and Health Science

Self Cite

108

119

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BackgroundPhysical activity (PA) includes muscle activity during exercise, manual work, and leisure time activities including sport. Conflicting results exist regarding health effects of PA that may deteriorate with manual work and elite sports, but improve when performed in moderation in accordance with international guidelines and may additionally enhance well-being and productivity.MethodsIn Denmark 15 randomized controlled trials have been conducted, introducing exercise at the workplace enrolling >3500 workers. The interventions lasted from 10 to 52 weeks and offered ~1 h weekly supervised exercise during working hours according to the concept of intelligent physical exercise training (IPET) that is based on evidenced sports sciences training principles and tailored to work exposure, employee health status, and physical capacity. Questionnaire surveys and health checks including blood and muscle sampling were performed at baseline and follow-up. The job groups included: office and computer workers, dentists, industrial technicians, cleaning personnel, health care workers, construction workers, and fighter/helicopter pilots.ResultsIn all job groups significant improvements were documented regarding health outcomes. These were job group specific: neck pain was reduced among office and computer workers, dentists, industrial laboratory technicians, health care workers as well as fighter pilots. Cardio-respiratory fitness—a health risk indicator for cardio-metabolic diseases—was improved among office and computer workers, health care workers, and construction workers. Additionally, other improvements were evidenced such as increased muscle strength and balance control. Importantly, productivity increased with improved muscle strength and decreased body mass index.ConclusionIPET does enhance health if an exercise program with evidenced efficacy is implemented by expert trainees with support of the employer. Accordingly, in every study group outcomes of improved health were documented and the effect sizes were of clinical relevance. Cost effectiveness estimates indicate acceptable cost relative to savings on health expenses and lost productivity.

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“…There may of course be some false positives among our findings, but all in all it does not seem sensible to dismiss all our results as a gigantic type I error. The MVDA methodology used in the present study is the same as used by the Linköping group in a number of recent peer-reviewed publications in different journals,22,29,62–66 and it is congruent with the principles argued for by Wheelock and Wheelock 28. Finally, in order to ensure the robustness of our statistical methodology, the CSF data of the present study were recomputed using the statistical methodology described by Moen et al32 (with use of false discovery rate); the result of this recomputation was exactly the same as the list presented in Table 1 (TG being the last author of both articles).…”

Section: Discussionmentioning

confidence: 99%

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma

Bäckryd¹,

Tanum²,

Lind³

et al. 2017

JPR

187

153

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In addition to central hyperexcitability and impaired top–down modulation, chronic inflammation probably plays a role in the pathophysiology of fibromyalgia (FM). Indeed, on the basis of both animal experiments and human studies involving the analysis of cytokines and other inflammation-related proteins in different body fluids, neuroinflammatory mechanisms are considered to be central to the pathophysiology of many chronic pain conditions. However, concerning FM, previous human plasma/serum and/or cerebrospinal fluid (CSF) cytokine studies have looked only at a few predetermined cytokine candidates. Instead of analyzing only a few substances at a time, we used a new multiplex protein panel enabling simultaneous analysis of 92 inflammation-related proteins. Hence, we investigated the CSF and plasma inflammatory profiles of 40 FM patients compared with CSF from healthy controls (n=10) and plasma from blood donor controls (n=46). Using multivariate data analysis by projection, we found evidence of both neuroinflammation (as assessed in CSF) and chronic systemic inflammation (as assessed in plasma). Two groups of proteins (one for CSF and one for plasma) highly discriminating between patients and controls are presented. Notably, we found high levels of CSF chemokine CX3CL1 (also known as fractalkine). In addition, previous findings concerning IL-8 in FM were replicated, in both CSF and plasma. This is the first time that such an extensive inflammatory profile has been described for FM patients. Hence, FM seems to be characterized by objective biochemical alterations, and the lingering characterization of its mechanisms as essentially idiopathic or even psychogenic should be seen as definitively outdated.

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Algogenic substances and metabolic status in work-related Trapezius Myalgia: a multivariate explorative study

Cited by 16 publications

References 87 publications

Discomfort glare and psychological stress during computer work: subjective responses and associations between neck pain and trapezius muscle blood flow

Discomfort glare and psychological stress during computer work: subjective responses and associations between neck pain and trapezius muscle blood flow

Exercise is more than medicine: The working age population's well-being and productivity

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma

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