Algometry for the assessment of central sensitisation to pain in fibromyalgia patients: a systematic review

Coba, Pablo de la; Montoro, Casandra I.; Paso, Gustavo A. Reyes del; Galvez-Sánchez, Carmen M.

doi:10.1080/07853890.2022.2075560

Cited by 12 publications

(8 citation statements)

References 90 publications

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“…Fibromyalgia is a classic example of nociplastic pain: widespread pain with a multitude of additional symptoms, such as fatigue, sleep, mood, and memory problems. Fibromyalgia patients show most distinct signs of central sensitization 16 and autonomic hyperactivation. 6 , 66 Chronic back pain, on the other hand, represents a very diverse category, with pain occurrence, resurgence, intensity, and pain-related disability varying widely.…”

Section: Discussionmentioning

confidence: 99%

Night time heart rate predicts next-day pain in fibromyalgia and primary back pain

Dudarev,

Barral,

Radaeva

et al. 2024

PR9

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Introduction: Primary chronic pain is pain that persists for over 3 months without associated measurable tissue damage. One of the most consistent findings in primary chronic pain is its association with autonomic hyperactivation. Yet whether the autonomic hyperactivation causes the pain or results from it is still unclear. It is also unclear to what extent autonomic hyperactivation is related to experienced pain intensity in different subtypes or primary chronic pain. Objectives: Our first aim was to test lagged relationships between the markers of autonomic activation (heart rate) and pain intensity to determine its directionality. The main question here was whether autonomic biomarkers predict pain intensity or whether pain intensity predicts autonomic biomarkers. The second aim was to test whether this relationship is different between people with primary back pain and people with fibromyalgia. Methods: Sixty-six patients with chronic pain were observed over an average of 81 days. Sleep heart rate and heart rate variability were measured with a wearable sensor, and pain intensity was assessed from daily subjective reports. Results: The results showed a predictive relationship between sleep heart rate and next-day pain intensity (P < 0.05), but not between daily pain intensity and next night heart rate. There was no interaction with the type of chronic pain. Conclusions: These findings suggest that autonomic hyperactivation, whether stress-driven or arising from other causes, precedes increases in primary chronic pain. Moreover, the present results suggest that autonomic hyperactivation is a common mechanism underlying the pain experience in fibromyalgia and chronic back pain.

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Section: Discussionmentioning

confidence: 99%

Night time heart rate predicts next-day pain in fibromyalgia and primary back pain

Dudarev,

Barral,

Radaeva

et al. 2024

PR9

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“…Although CPM is mainly used as an inhibitory pain modulation paradigm, the underlying processes involve both complex central facilitatory and inhibitory mechanisms of pain processing; the specific mechanisms involved in this pain characteristic are not yet fully understood. 10 , 49 The CPM protocol in this study included rapidly ramping up pressure on the nondominant leg, which was constant from then on, and simultaneously steadily increasing pressure on the dominant leg to capture the conditioned PDT and PTT. The CPM effect (CPM PDT and CPM PTT ) was calculated as the difference between the PDT (and PTT) of the dominant leg during conditioning and the PDT (and PTT) measured at baseline.…”

Section: Methodsmentioning

confidence: 99%

“…2 For several pain modalities, patients with chronic pain showed significantly lower pain thresholds and pain tolerance levels, 45 increased TSP and SSP, 34,45 and deficient CPM compared with healthy controls. 10,12,27,34,36,45 However, little is known about the influence of an immersive environment on these parameters. Such knowledge could provide valuable information for future Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.…”

Section: Introductionmentioning

confidence: 99%

Effects of virtual reality on psychophysical measures of pain: superiority to imagination and nonimmersive conditions

Tesarz,

Herpel,

Meischner

et al. 2023

Pain

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Virtual reality (VR) has been shown to be effective in pain management. However, to date, little is known about the mechanisms by which immersive experiences influence pain processing. The aim of this study was to investigate the direct effects of an immersive VR environment on the perception of experimental pain in individuals with chronic pain and pain-free controls. The immersion in a VR landscape was compared with mental imagery and a nonimmersive control condition. Using a randomized within-crossover design, pressure pain detection and tolerance thresholds, spatial and temporal summation (SSP, TSP), and conditioned pain modulation (CPM) were measured in 28 individuals with chronic pain and 31 pain-free controls using phasic cuff pressure on the legs. Direct comparison between the groups showed that although individuals with pain had significantly lower pain thresholds, reduced CPM effects, and increased TSP, the VR condition had the same pain-inhibitory effect on pain thresholds as in pain-free controls. Conditioned pain modulation effects were reduced by all conditions compared with baseline. There were no significant differences between conditions and baseline for TSP and SSP. Overall, pain modulatory effects were largest for VR and smallest for imagery. These results demonstrate that immersion in a VR environment has an increasing effect on pain thresholds, reduces pain inhibition in a CPM paradigm, and has no effects on TSP. This applies for participants with chronic pain and pain-free controls. These VR effects exceeded the effects of mental imagery on the nonimmersive control condition. This indicates that VR effectively modulates pain perception in both patients and controls irrespective of differences in pain perception.

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“…Another key symptom is central sensitization which is reflected in tactile hyperalgesia, exaggerated responsivity to pain, and allodynia, increased sensitivity to innocuous stimuli ( Clauw et al, 2011 , Desmeules et al, 2003 , Latremoliere and Woolf, 2009 , Meeus and Nijs, 2007 ). Indeed, lower pain thresholds for mechanical (pressure) and thermal (heat and cold) stimuli in participants with FM have been well-established ( de la Coba et al, 2022 , Desmeules et al, 2003 , Plesner and Vaegter, 2018 ). Similarly, people with FM show increased sensitivity to electrical stimulation ( Erturk Celik and Beyazova, 2020 , Rhudy et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Neural indices of multimodal sensory and autonomic hyperexcitability in fibromyalgia

Marinkovic,

Woodruff,

White

et al. 2023

Neurobiology of Pain

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Algometry for the assessment of central sensitisation to pain in fibromyalgia patients: a systematic review

Cited by 12 publications

References 90 publications

Night time heart rate predicts next-day pain in fibromyalgia and primary back pain

Night time heart rate predicts next-day pain in fibromyalgia and primary back pain

Effects of virtual reality on psychophysical measures of pain: superiority to imagination and nonimmersive conditions

Neural indices of multimodal sensory and autonomic hyperexcitability in fibromyalgia

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