Algorithm using Neuron-Specific Enolase and Pro-Gastrin-Releasing Peptide to Increase the Diagnostic Accuracy for Small Cell Lung Cancer

Lee, Haeyoung; Park, Sung Dal; Kim, Taeyun; Jang, Tae Won; Choi, Hyunji; Hwang, Hyunyong

doi:10.3343/alm.2021.41.3.339

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…A large‐scale study successfully constructed a LC risk model with CYFRA21‐1, SCC‐Ag, proGRP, and CEA as the analysis objects, which was demonstrated to have a good predictive effect for early LC and pulmonary nodules [ 74 ]. Lee et al [ 75 ] used NSE and proGRP to increase diagnostic accuracy for SCLC. By maintaining the high diagnostic specificity of proGRP, this improved its relatively low sensitivity from 75% to 87.5%.…”

Section: Discussionmentioning

confidence: 99%

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Bibliometric and visualized analysis of applying tumor markers in lung cancer diagnosis from 2000 to 2022

Chen

et al. 2023

Cancer Innovation

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BackgroundLung cancer (LC) is the leading cause of cancer‐related deaths worldwide. Tumor marker (TM) detection can indicate the existence and growth of a tumor and has therefore been used extensively for diagnosing LC. Here, we conducted a bibliometric analysis to examine TM‐related publications for LC diagnosis to illustrate the current state and future trends of this field, as well as to identify additional promising TMs with high sensitivity.MethodsPublications regarding TMs in LC diagnosis were downloaded from the Web of Science Core Collection. CiteSpace was applied to perform a bibliometric analysis of journals, cocitation authors, keywords, and references related to this field. VOSviewer was used to generate concise diagrams about countries, institutions, authors, and keywords. Changes in the TM research frontier were analyzed through citation burst detection.ResultsA total of 990 studies were analyzed in this work. The collaboration network analysis revealed that the People's Republic of China, Yonsei University, and Molina R were the most productive country, institution, and scholar, respectively. Additionally, Molina R was the author with the most citations. The National Natural Science Foundation of China was the largest funding source. “Carcinoembryonic antigen (CEA) as tumor marker in lung cancer” was the top reference with the most citations, Lung Cancer was the core journal, and “serum tumor marker” experienced a citation burst over the past 5 years.ConclusionThis bibliometric analysis of TMs in LC diagnosis presents the current trends and frontiers in this field. We summarized the research status of this field and the methods to improve the diagnostic efficacy of traditional serum TMs, as well as provided new directions and ideas for improving the LC clinical detection rate. Priority should be given to the transformation of computer‐assisted diagnostic technology for clinical applications. In addition, circulating tumor cells, exosomes, and microRNAs were the current most cutting‐edge TMs.

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Section: Discussionmentioning

confidence: 99%

“…good predictive effect for early LC and pulmonary nodules [74]. Lee et al [75] used NSE and proGRP to increase diagnostic accuracy for SCLC. By maintaining the high diagnostic specificity of proGRP, this improved its relatively low sensitivity from 75% to 87.5%.…”

Section: Methods To Improve Diagnostic Sensitivity and Specificitymentioning

confidence: 99%

Bibliometric and visualized analysis of applying tumor markers in lung cancer diagnosis from 2000 to 2022

Chen

et al. 2023

Cancer Innovation

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Potential and application of abortive transcripts as a novel molecular marker of cancers

Zhang,

Zhu,

Qin

et al. 2024

World J Exp Med

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Abortive transcript (AT) is a 2-19 nt long non-coding RNA that is produced in the abortive initiation stage. Abortive initiation was found to be closely related to RNA polymerase through in vitro experiments. Therefore, the distribution of AT length and the scale of abortive initiation are correlated to the promoter, discriminator, and transcription initiation sequence, and can be affected by transcription elongation factors. AT plays an important role in the occurrence and development of various diseases. Here we summarize the discovery of AT, the factors responsible for AT formation, the detection methods and biological functions of AT, to provide new clues for finding potential targets in the early diagnosis and treatment of cancers.

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Algorithm using Neuron-Specific Enolase and Pro-Gastrin-Releasing Peptide to Increase the Diagnostic Accuracy for Small Cell Lung Cancer

Cited by 2 publications

References 9 publications

Bibliometric and visualized analysis of applying tumor markers in lung cancer diagnosis from 2000 to 2022

Bibliometric and visualized analysis of applying tumor markers in lung cancer diagnosis from 2000 to 2022

Potential and application of abortive transcripts as a novel molecular marker of cancers

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