Alice in Wonderland syndrome as an initial manifestation of Epstein-Barr virus infection.

Cinbiş, Mine; Aysun, Sabiha

doi:10.1136/bjo.76.5.316

Cited by 53 publications

(19 citation statements)

References 10 publications

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“…The presence of atypical manifestations, progressive weight loss and reduced growth mandate medical diagnostic workup for exclusion of an organic cause. Neuroimaging and neurophysiologic assessments were needed to exclude other causes of AWLS as epilepsy [ 9 ], infectious mononucleosis [ 23 ], epstein-Barr virus infection [ 24 ], cerebral vasculitis [ 25 ], psychosis [ 26 ] and drug adverse effect or intoxication [ 27 , 28 ]. Normal diffusion-weighted MRI is consistent with the diagnosis of migraine.…”

Section: Discussionmentioning

confidence: 99%

A migraine variant with abdominal colic and Alice in wonderland syndrome: a case report and review

Hamed

2010

BMC Neurol

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BackgroundAbdominal migraine is a commonly described migraine variant in children and young adults, but associations with Alice in Wonderland syndrome and lilliputian hallucinations are exceptional.Case presentationA 20 years-old male experienced frequent and prolonged attacks of abdominal colic associated with autonomic manifestations started at the age of ten. At the age of 17, he additionally described prolonged attacks (≥ 7 days) of distortions of shape, size or position of objects or subjects. He said "Quite suddenly, objects appear small and distant (teliopsia) or large and close (peliopsia). I feel as I am getting shorter and smaller "shrinking" and also the size of persons are not longer than my index finger (a lilliputian proportion). Sometimes I see the blind in the window or the television getting up and down, or my leg or arm is swinging. I may hear the voices of people quite loud and close or faint and far. Occasionally, I experience attacks of migrainous headache associated with eye redness, flashes of lights and a feeling of giddiness. I am always conscious to the intangible changes in myself and my environment". There is a strong family history of common migraine. Clinical examination, brain-MRI and EEG were normal. Transcranial magnetic stimulation and evoked potentials revealed enhanced cortical excitability in multiple brain regions. Treatment with valproate resulted in marked improvement of all clinical and neurophysiological abnormalities.ConclusionsThe association between the two migraine variants (abdominal migraine and Alice in Wonderland Syndrome) might have clinical, pathophysiological and management implications. I think this is the first description in the literature.

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Section: Discussionmentioning

confidence: 99%

A migraine variant with abdominal colic and Alice in wonderland syndrome: a case report and review

Hamed

2010

BMC Neurol

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“…One girl, younger than her affected brother, had episodes of what she called "crooked vision" in which there was a shift in perception so everything looked small. According to her mother, doctors ruled out a diagnosis of A-T for her, and decided it was a variant of migraine, the "Alice in Wonderland" syndrome [Cinbis and Aysun, 1992]. Apparently, this visual disturbance occurred twice, 2 years previously and several months prior to the interview.…”

Section: The Sib Relationshipmentioning

confidence: 98%

?My crooked vision?: The well sib views ataxia-telangiectasia

Fanos

1999

Am. J. Med. Genet.

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The ataxia-telangiectasia gene (designated ATM) has been identified by positional cloning. Retrospective studies in cystic fibrosis (CF) have shown that the illness and death of a sib have far-reaching ramifications on the surviving sib's life. However, there have been no studies on sibs of children and adults with ataxia-telangiectasia (A-T). Thirty-five sibs from 24 families, including 26 adults and 9 adolescents, were drawn from the University of California, Los Angeles; the A-T Clinical Center at the Johns Hopkins University School of Medicine; and the A-T Children's Project Interviews indicated that, unlike CF, the visibility of A-T caused less resentment of time or attention given to the affected, less guilt, and less identification or idealization of the affected, but more embarrassment and shame. It may be said that, unlike CF, the dynamic is one of burden rather than trauma. The specific phenotypic expression of a genetic illness predisposes the way in which the well sib will encounter problems. In A-T affected families, one must help families locate caregiving resources so they will not burden their well children; sibs need help with managing feelings of embarrassment and shame. Geneticists must be alert to understanding characteristic differences of disorders they encounter in order to offer the most appropriate support to affected families.

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“…Six of these patients had undergone serological studies for Epstein-Barr virus infection. Cinbis and Aysun [6] and Liaw and Shen [7] have also reported patients with serologically confirmed Epstein-Barr virus infection who had illusions of size, shape, color of objects, and bizarre feelings about their body image. This syndrome was also identified in a case of coxsackievirus B1 infection [8] and in two 11-year-old patients with juvenile migraine [9].…”

Section: Discussionmentioning

confidence: 99%

‘Alice in Wonderland’ Syndrome as a Precursor of Depressive Disorder

Mizuno¹,

Kashima²,

Chiba³

et al. 1998

Psychopathology

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A 54-year-old Japanese businessman who was found to exhibit the ‘Alice in Wonderland’ syndrome and went on to develop a depressive disorder is described. Lengthening and shortening of time experience continued intermittently for about 3 months, and metamorphopsia, distortion of body image, and the quick-motion phenomenon (alteration in time sense) persisted for almost 2 days without interruption. There were no abnormal physical findings. The authors review studies on ‘Alice in Wonderland’ syndrome and suggest that depressive illness may be a causal factor.

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Alice in Wonderland syndrome as an initial manifestation of Epstein-Barr virus infection.

Cited by 53 publications

References 10 publications

A migraine variant with abdominal colic and Alice in wonderland syndrome: a case report and review

A migraine variant with abdominal colic and Alice in wonderland syndrome: a case report and review

?My crooked vision?: The well sib views ataxia-telangiectasia

‘Alice in Wonderland’ Syndrome as a Precursor of Depressive Disorder

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