Alien limb syndrome induced by a dopamine agonist in a patient with parkinsonism and agenesis of the corpus callosum

Krause, M; Shou, James; Joy, Sanju P; Torres-Russotto, Diego

doi:10.1016/j.parkreldis.2017.03.011

Cited by 2 publications

(1 citation statement)

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“…Corpus callosum agenesis (CCA) forms a failure to develop the large bundle of fibers that connect the cerebral hemispheres and a disruption in interhemispheric connections. CCA induces a range of abnormalities in brain structure and function, mostly psychiatric disorders, cognitive decline, and epilepsy, some rare cases are also present such as bilateral degenerative changes and alien limb syndrome in Parkinson disease patients, [1,2] CCA together with congenital lymphedema and other hereditary disorders. [3,4] In this article, we present a patient diagnosed with SIH in whom the images revealed CCA.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous intracranial hypotension in a patient without corpus callosum: A case report

Zhou,

Tong

2024

Medicine

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Rationale: Spontaneous intracranial hypotension (SIH) is a well-established condition typically presenting with disabling orthostatic headache. Corpus callosum agenesis (CCA) is one of the most common human brain malformations with a wide spectrum of associated malformations, chromosomal abnormalities, and clinical syndromes. Patient concerns: A 53-year-old woman presented with recurrent orthostatic headache for about 1 month. The head computed tomography examination of the patient showed CCA and the initial pressure of subsequent lumbar puncture was only 5 centimeters cerebrospinal fluid. Magnetic resonance imaging examination confirmed CCA with gray matter heterotopia. Diagnosis: The final diagnose was SIH related headache with CCA. Intervention: The patient’s symptom improved after oral hydration, intravenous fluids, and bed rest. Outcome: Favorable outcome was observed. Lessons: Although this co-occurrence of SIH and CCA is probably coincidental, this finding suggests that the developmental malformations of the brain may lead to structural changes in brain tissue or disturbances in cerebrospinal fluid production and reflux, resulting in pathological changes over time.

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