Aligned poly (glycolide‐lactide) fiber membranes with conducting polypyrrole

Abstract

Electroactive polypyrrole (PPy) are highly attractive for a number of biomedical applications such as tissue engineering. To improve interfacial compatibility of PPy with biopolyesters, poly (ɛ‐caprolactone) grafted PPy (PPy‐g‐PCL) are synthesized in this work and characterized with Fourier transform infrared and nuclear magnetic resonance. PPy‐g‐PCL exhibits good conductivity and electrochemical activity. It is also blended with poly (glycolide‐lactide) to make aligned fiber membranes via drum at the speed of 1500 r/min. The relationships of blending ratio with the fibrous structure, thermal stability, wettability, and mechanical properties are clarified. The results show that blending PPy‐g‐PCL has no significant effect on the fibrous morphology, but fibers trends aligned architecture as the blend ratio of poly (glycolide‐lactide)/PPy‐g‐PCL exceeds 70/30. The membranous thermal and mechanical stability are modified. The membranous hydrophilicity significantly enhances with PPy‐g‐PCL amount increasing. Then the fiber membrane with topographical and electrical cues is qualified as the application of tissue engineering. Copyright © 2016 John Wiley & Sons, Ltd.

Highly aligned bacterial cellulose/PPy gradient conductive membranes for directed cell differentiation under electrical stimulation

“…MPa, with a Young's modulus of 238.6 MPa, while the tensile strength of the stretched BC/PPy gradient conductive membranes reached 34.1 MPa, with a Young's modulus of 1849.9 MPa (***P < 0.005). It has also been reported in previous studies that the tensile strength and Young's modulus increased with the deposition of PPy and the alignment of nano bers [11,35]. In the present study, the improvement in mechanical properties of stretched BC/PPy gradient conductive membranes could be related to two reasons.…”

Conducting Polymer Grafting: Recent and Key Developments

“…Apart from the oligomer approach macromonomer approach is also very effective for the development of degradable conducting graft copolymers. To exemplify, PCL grafted PPy was synthesized by Guo et al [72] aiming the fibrous membrane formation for biomedical applications. First, pyrrole-g-PCL (Py-g-PCL) macromonomer was synthesized using ROP of caprolactone.…”

“…and (iv) catalyst-transfer polycondensation from acceptor polymers based macroinitiator. [72] In recent years, the development of all-conjugated donor-acceptor based polymer solar cell has gained high attention because the presence of both donor and acceptor segments in a single polymer chain can contribute easily to fabricate high performance solar cell. The general methods for the synthesis of all-conjugated donor-acceptor graft copolymers are beautifully summarized in a minireview article by Wang et al [74].…”

Advances in Conducting, Biodegradable and Biocompatible Copolymers for Biomedical Applications

“…Recently, some of these graft copolymers based on electroactive macromonomer approach have been effectively proposed for biomedical field, mainly based on pyrrole (Domagala et al, 2014;Guo et al, 2017) aniline (Figure 1Div) (Chao et al, 2007;Peng et al, 2011) or thiophene groups, (Türkan et al, 2011) but most works are using the electroactive aniline-based oligomers previously discussed in this minireview. Although some research groups propose new synthetic routes for novel copolymers and characterize the physical chemistry properties which could be useful in biomedical applications, studies of biocompatibility are not commonplace.…”