Aligned Rank Tests for Interactions in Split-Plot Designs: Distributional Assumptions and Stochastic Heterogeneity

Beasley, T. Mark; Zumbo, Bruno D.

doi:10.22237/jmasm/1241136180

Cited by 18 publications

(15 citation statements)

References 81 publications

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“…In particular, to explore the main effects, we used an Aligned Rank Transformation (ART) as described by Wobbrock, Findlater, Gergle and Higgins 39 with the r package ARTool 40 . To test for interactions, we used a non-parametric ART test for interactions in designs with repeated measures as described by Beasley & Zumbo 41 with the r package “npIntFactRep” 42 . However, while this last package permits to test effects for mixed models with one ‘ within’ and one ‘ between’ factors, it does not allow for testing interactions with more than one ‘ within’ factors, hence we only ran interaction tests for the Threshold elevation data.…”

Section: Methodsmentioning

confidence: 99%

Spontaneous and training-induced cortical plasticity in MD patients: Hints from lateral masking

Maniglia

Soler

Cottereau

et al. 2018

Sci Rep

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Macular degeneration (MD) affects central vision and represents the leading cause of visual diseases in elderly population worldwide. As a consequence of central vision loss, MD patients develop a preferred retinal locus (PRL), an eccentric fixation point that replaces the fovea. Here, our aim was to determine whether and to what extent spontaneous plasticity takes place in the cortical regions formerly responding to central vision and whether a visual training based on perceptual learning (PL) can boost this plasticity within the PRL area. Spontaneous and PL-induced cortical plasticity were characterized by using lateral masking, a contrast sensitivity modulation induced by collinear flankers. This configuration is known to be sensitive to neural plasticity and underlies several rehabilitation trainings. Results in a group of 4 MD patients showed that collinear facilitation was similar to what observed in age- and eccentricity-matched controls. However, MD patients exhibited significantly reduced collinear inhibition, a sign of neural plasticity, consistent with the hypothesis of partial cortical reorganization. Three AMD patients from the same group showed a further reduction of inhibition after training, but not controls. This result suggests that PL might further boost neural plasticity, opening promising perspectives for the development of rehabilitation protocols for MD patients.

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Section: Methodsmentioning

confidence: 99%

Spontaneous and training-induced cortical plasticity in MD patients: Hints from lateral masking

Maniglia

Soler

Cottereau

et al. 2018

Sci Rep

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show abstract

“…Since the bubble scores were calculated on an ordinal scale and given the size of analyzed sample, we used nonparametric tests for comparisons. The Higgins & Tashtoush formula for repeated measures (at 0, 30, 60 and 90 minutes after decompression) was used for the interaction alignments with the aligned Koch rank score (based on ranking the K² pairwise differences among the 4 levels of the repeated measures, regardless of treatment membership ranks), and the resulting p-value was reported [ 13 , 14 ] Between groups differences per time point and for the cumulative bubble score were analyzed using paired Wilcoxon tests adjusted for multiple comparisons by the Hochberg method [ 15 ]. Differences in biometric data were tested by Student’s T-test, Mann Whitney U tests or Chi-square tests, as appropriate.…”

Section: Methodsmentioning

confidence: 99%

Enriched Air Nitrox Breathing Reduces Venous Gas Bubbles after Simulated SCUBA Diving: A Double-Blind Cross-Over Randomized Trial

et al. 2016

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ObjectiveTo test the hypothesis whether enriched air nitrox (EAN) breathing during simulated diving reduces decompression stress when compared to compressed air breathing as assessed by intravascular bubble formation after decompression.MethodsHuman volunteers underwent a first simulated dive breathing compressed air to include subjects prone to post-decompression venous gas bubbling. Twelve subjects prone to bubbling underwent a double-blind, randomized, cross-over trial including one simulated dive breathing compressed air, and one dive breathing EAN (36% O2) in a hyperbaric chamber, with identical diving profiles (28 msw for 55 minutes). Intravascular bubble formation was assessed after decompression using pulmonary artery pulsed Doppler.ResultsTwelve subjects showing high bubble production were included for the cross-over trial, and all completed the experimental protocol. In the randomized protocol, EAN significantly reduced the bubble score at all time points (cumulative bubble scores: 1 [0–3.5] vs. 8 [4.5–10]; P < 0.001). Three decompression incidents, all presenting as cutaneous itching, occurred in the air versus zero in the EAN group (P = 0.217). Weak correlations were observed between bubble scores and age or body mass index, respectively.ConclusionEAN breathing markedly reduces venous gas bubble emboli after decompression in volunteers selected for susceptibility for intravascular bubble formation. When using similar diving profiles and avoiding oxygen toxicity limits, EAN increases safety of diving as compared to compressed air breathing.Trial RegistrationISRCTN 31681480

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“…The Beasley and Zumbo (2009) procedure yielded all significant p-values, 0.0427, 0.0054, and 0.0339, respectively, for the aligned regular, Friedman, and Koch rank tests. The ARTool resulted in a non-significant value p = 0.0544.…”

Section: Nonparametric Testsmentioning

confidence: 92%

New Nonparametric Rank Tests for Interactions in Factorial Designs with Repeated Measures

Feys

2016

J. Mod. App. Stat. Meth.

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Aligned Rank Tests for Interactions in Split-Plot Designs: Distributional Assumptions and Stochastic Heterogeneity

Cited by 18 publications

References 81 publications

Spontaneous and training-induced cortical plasticity in MD patients: Hints from lateral masking

Spontaneous and training-induced cortical plasticity in MD patients: Hints from lateral masking

Enriched Air Nitrox Breathing Reduces Venous Gas Bubbles after Simulated SCUBA Diving: A Double-Blind Cross-Over Randomized Trial

New Nonparametric Rank Tests for Interactions in Factorial Designs with Repeated Measures

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