The grism, slitless spectrometer aboard the Wide Field Infrared Survey Telescope (WFIRST) enables a survey of emissionline galaxies. To facilitate its opto-mechanical alignment, a six-degree-of-freedom element was fabricated using alignment fiducials and integral flats and used to measure a wavefront by using an infrared interferometer placed at various field points over a 20×14-degree field of view in the grism coordinate frame. Modeling identified E2 to be the most sensitive element to the grism WFE and was used to efficiently align the system. The merit function regression method for a wide field of view was further used to verify the higher efficiency and accuracy of the proposed alignment technique compared with the conventional sensitivity table method.