Aliphatic Polyesters

Albertsson, Ann‐Christine; Varma, I. K.

doi:10.1002/3527600035.bpol4002

Cited by 98 publications

(139 citation statements)

References 153 publications

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“…[1,2] Aliphatic polyesters such as polyglycolide, PG, poly(L-lactide), PLL, polycaprolactone, PCL, and polyhydroxybutyrate, PHB, are widely used in various biomedical applications such as absorbable sutures, tissue-supporting scaffolds, nerve guides and drug delivery devices. [3,4] These polymers can biodegrade in the human body via simple hydrolysis of their ester linkages to low molecular weight products which are either metabolizable or excretable without any adverse toxicological effects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Processing and Tensile Testing of a Poly(l‐lactide‐co‐caprolactone) Monofilament Fiber for Use as an Absorbable Surgical Suture

Ruengdechawiwat

Molloy

Siripitayananon

et al. 2015

Macromolecular Symposia

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Summary: Summary A poly(L-lactide-co-caprolactone), P(LL-co-CL), 75:25 mol % copolymer was synthesized via the bulk ring-opening copolymerization of L-lactide (LL) and e-caprolactone (CL) at 130 C for 48 hrs. The P(LL-co-CL) copolymer obtained was characterized in terms of its molecular weight (GPC), copolymer composition ( 1 H-NMR), monomer sequencing ( 13 C-NMR) and thermal properties (DSC, TGA). For processing, the P(LL-co-CL) was melt spun into a monofilament fiber with fast cooling and minimal draw in order to produce an as-spun fiber that was largely amorphous and unoriented. This enabled the required oriented semi-crystalline morphology to be gradually built into the as-spun fiber in a series of controlled off-line annealing and hot-drawing steps. The final fiber, which combined sufficient tensile strength with flexibility for use as a suture material, exhibited a stress and strain at break of 344 MPa and 70%, respectively.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Processing and Tensile Testing of a Poly(l‐lactide‐co‐caprolactone) Monofilament Fiber for Use as an Absorbable Surgical Suture

Ruengdechawiwat

Molloy

Siripitayananon

et al. 2015

Macromolecular Symposia

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“…In this study, we defined low molar weight PCL as oligomer hav- [19]. SnOct 2 is well known for causing transesterification reactions at elevated temperatures [2]. For PCL 5 kDa, only MALDI spectra for low molar mass fraction were detected because of high PDI.…”

Section: Rop and Functionalization Of Vinyl-pclmentioning

confidence: 99%

“…ROP of cyclic ester makes it possible to prepare polyesters with defined molar weights, low polydispersity index, and functionalized end groups, due to the absence or very limited side reactions and by products [2]. To enable photo curing of PCL, monofunctional vinyl ether, in this case is HBVE, was incorporated into each PCL chain.…”

Section: Rop and Functionalization Of Vinyl-pclmentioning

confidence: 99%

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Synthesis, characterization and photopolymerization of vinyl functionalized poly (ε-caprolactone)

Liow¹,

Widjaja²,

Lipik³

et al. 2009

Express Polym. Lett.

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Abstract. Vinyl functionalized poly (ε-caprolactone) with molar mass ranging from 500-5000 Da were synthesized by ring opening polymerization and further photopolymerized. One-step synthesis and functionalization is achieved based on ring opening polymerization (ROP). Hydroxyl butyl vinyl ether (HBVE) was employed to play the role as the initiator of ROP, and photo-curable functional group. The presence of CH2=CH peak in Fourier Transform Infrared (FTIR) spectra confirmed that vinyl end groups were successfully attached to poly (ε-caprolactone) (PCL) macromolecule. Kinetic parameters of cationic photopolymerization of vinyl functionalized PCL were investigated. The activation energy was estimated at 11.33 kJ/mol, by assuming the cationic system followed second-order autocatalytic model.

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“…The biodegradable polymers that have been most intensively investigated are aliphatic polyesters derived from the following monomers: lactide, glycolide, butyrolactone and caprolactone [1,2]. Their polyesters and copolyesters represent the main group of interest [3][4][5][6][7][8][9] due to their long history of safety.…”

Section: Introductionmentioning

confidence: 99%

New Biocompatible Polyesters Derived from α-Amino Acids: Hydrolytic Degradation Behavior

2010

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New polymers were synthesized from α-hydroxy acids derived from the natural amino acids Ile, Leu, Phe, and Val, combined with lactic acid, glycolic acid and 6-hydroxyhexanoic acid by direct condensation. The toxicity was determined and the degradation process of these polyesters was investigated under physiological conditions by analyzing the composition of the degraded polymers and the oligomers cleaved in the buffer medium. The polymers were found to be non toxic to two cell lines. Polymers displayed a biphasic degradation behavior. In most cases, a linear relationship was found between the weight loss constant and the hydrophobicity of the polymers, Log P. Regarding the second stage of weight loss, it is apparent that polymers derived from α-hydroxy(L)isoleucine ((L)HOIle) and α-hydroxy(L)Valine ((L)HOVal) degraded much faster than those derived from α-hydroxy(L)leucine ((L)HOLeu) and α-hydroxy(L)phenylalanine ((L)HOPhe), probably due to different spatial orientation of the side chains. Copolymers of 6-hydroxyhexanoic acid displayed slow degradation rates as expected, whereas the degradation profile of copolymers of lactic acid was similar to the other homopolymers. These new polyesters may serve as potential biocompatible materials for medical applications.

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Aliphatic Polyesters

Abstract: Introduction Historical Outline Chemical Structure Naturally Occurring Polyesters: Shellac Microbial Polyesters Condensation Polyesters Polyesters Prepared by ROP Structural Modification by Copolymerization Occurr… Show more

Cited by 98 publications

References 153 publications

Synthesis, Processing and Tensile Testing of a Poly(l‐lactide‐co‐caprolactone) Monofilament Fiber for Use as an Absorbable Surgical Suture

Synthesis, Processing and Tensile Testing of a Poly(l‐lactide‐co‐caprolactone) Monofilament Fiber for Use as an Absorbable Surgical Suture

Synthesis, characterization and photopolymerization of vinyl functionalized poly (ε-caprolactone)

New Biocompatible Polyesters Derived from α-Amino Acids: Hydrolytic Degradation Behavior

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