Aliskiren Reduces Morning Blood Pressure in Hypertensive Patients with Diabetic Nephropathy

Takenaka, Tsuneo; Nobe, Kanako; Okayama, Mika; Kojima, Eriko; Nodaira, Yuka; Sueyoshi, Keita; Hoshi, Hitoshi; Watanabe, Yusuke; Takane, Hiroshi; Suzuki, Hiromichi

doi:10.3109/10641963.2012.681080

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…Strategies to downregulate the RAS include the knockdown or knockout of ANG II receptors, the use of ANG II receptor blockers that interfere with ANG II signaling, and the use of angiotensin-converting enzyme and renin inhibitors, which reduce ANG II levels by inhibiting its formation. Pharmacological tools are also effective in the treatment of hypertensive patients (70,667,702). Furthermore, ANG II-induced hypertension models can be divided into renin-dependent and low-renin models.…”

Section: Angiotensin Ii-induced Hypertensionmentioning

confidence: 99%

Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension

Gonzalez‐Vicente

Sáez

Monzón

et al. 2019

Physiological Reviews

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The thick ascending limb plays a key role in maintaining water and electrolyte balance. The importance of this segment in regulating blood pressure is evidenced by the effect of loop diuretics or local genetic defects on this parameter. Hormones and factors produced by thick ascending limbs have both autocrine and paracrine effects, which can extend prohypertensive signaling to other structures of the nephron. In this review, we discuss the role of the thick ascending limb in the development of hypertension, not as a sole participant, but one that works within the rich biological context of the renal medulla. We first provide an overview of the basic physiology of the segment and the anatomical considerations necessary to understand its relationship with other renal structures. We explore the physiopathological changes in thick ascending limbs occurring in both genetic and induced animal models of hypertension. We then discuss the racial differences and genetic defects that affect blood pressure in humans through changes in thick ascending limb transport rates. Throughout the text, we scrutinize methodologies and discuss the limitations of research techniques that, when overlooked, can lead investigators to make erroneous conclusions. Thus, in addition to advancing an understanding of the basic mechanisms of physiology, the ultimate goal of this work is to understand our research tools, to make better use of them, and to contextualize research data. Future advances in renal hypertension research will require not only collection of new experimental data, but also integration of our current knowledge.

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Section: Angiotensin Ii-induced Hypertensionmentioning

confidence: 99%

Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension

Gonzalez‐Vicente

Sáez

Monzón

et al. 2019

Physiological Reviews

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“…Interestingly, the mechanism of renal protection of aliskiren in the DN state is not achieved by lowering blood pressure. After 6 months of follow-up, aliskiren was found to reduce albuminuria levels in DN patients, but did not change the glomerular filtration rate or blood pressure ( 94 ). Studies have shown that the inhibition of ER stress may be one of its molecular mechanisms.…”

Section: Er Stress Inhibitormentioning

confidence: 99%

Endoplasmic reticulum homeostasis: a potential target for diabetic nephropathy

et al. 2023

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The endoplasmic reticulum (ER) is the most vigorous organelle in intracellular metabolism and is involved in physiological processes such as protein and lipid synthesis and calcium ion transport. Recently, the abnormal function of the ER has also been reported to be involved in the progression of kidney disease, especially in diabetic nephropathy (DN). Here, we reviewed the function of the ER and summarized the regulation of homeostasis through the UPR and ER-phagy. Then, we also reviewed the role of abnormal ER homeostasis in residential renal cells in DN. Finally, some ER stress activators and inhibitors were also summarized, and the possibility of maintaining ER homeostasis as a potential therapeutic target for DN was discussed.

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“…The efficacy of aliskiren on blood pressure reduction has been evaluated in animal experiments [6,7], as well as in patients with CKD [8] and diabetes [9]. The antihypertensive effect of aliskiren remains relatively long, even after treatment withdrawal [7], and is comparable or superior with that of other antihypertensive agents at recommended doses [10].…”

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confidence: 99%