Alisol B, a triterpene from<i>Alismatis rhizoma</i>(dried rhizome of<i>Alisma orientale</i>), inhibits melanin production in murine B16 melanoma cells

Yoshida, Ichiro; Ito, Chihiro; Matsuda, Shinya; Tsuji, Akihiko; Yanaka, Noriyuki; Yuasa, Keizo

doi:10.1080/09168451.2016.1268042

Cited by 14 publications

(4 citation statements)

References 30 publications

(28 reference statements)

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“…Modern medical researches about this herb found active ingredients in it and numerous studies have shown that Rhizoma Alismatis extract has various biological activities, such as hypolipemic, antidiabetic, anti‐urinary stone, anti‐inflammation and anti‐tumour activities. Li S et al found that Rhizoma Alismatis extract can significantly reduce the serum LDL levels of ApoE‐/‐ mice and promote the removal of chylomicron in the liver .…”

Section: Introductionmentioning

confidence: 99%

Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway

Gao

Zheng

et al. 2019

J Cellular Molecular Medi

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Obesity and its associated metabolic disorders such as diabetes, hepatic steatosis and chronic heart diseases are affecting billions of individuals. However there is no satisfactory drug to treat such diseases. In this study, we found that alisol A, a major active triterpene isolated from the Chinese traditional medicine Rhizoma Alismatis, could significantly attenuate high‐fat‐diet‐induced obesity. Our biochemical detection demonstrated that alisol A remarkably decreased lipid levels, alleviated glucose metabolism disorders and insulin resistance in high‐fat‐diet‐induced obese mice. We also found that alisol A reduced hepatic steatosis and improved liver function in the obese mice model.In addition, protein expression investigation revealed that alisol A had an active effect on AMPK/ACC/SREBP‐1c pathway. As suggested by the molecular docking study, such bioactivity of alisol A may result from its selective binding to the catalytic region of AMPK.Therefore, we believe that Alisol A could serve as a promising agent for treatment of obesity and its related metabolic diseases.

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Section: Introductionmentioning

confidence: 99%

Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway

Gao

Zheng

et al. 2019

J Cellular Molecular Medi

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“…Alisma contains triterpenoids, which can significantly lower cholesterol and triglyceride levels in the blood and aid in averting atherosclerosis and reducing the risk of cardiovascular and cerebrovascular diseases [8,9]. In recent years, studies have also confirmed that it possesses antitumor effects [11,12]. It has been demonstrated that a key component of Alisma, Alisol B, exhibits anticancer activity against various cancer cells due to the cytotoxicity and anti-metastatic effects of its alisol compounds [13,17].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Alisma has been found to enhance the antitumor effects of Bufalin in liver cancer through modulation of the Wnt/β-Catenin axis [11]. Additionally, Alisol B, a triterpenoid derived from Alisma, inhibits melanin production in mouse melanoma cells [12]. Alisol B 23-acetate has been shown to induce autophagy-dependent apoptosis in colon cancer cells through the production of reactive oxygen species (ROS) and activation of the c-Jun N-terminal kinase (JNK) pathway [13].…”

Section: Introductionmentioning

confidence: 99%

Alisma orientale extract inhibits cell proliferation by promoting oxidative stress and apoptosis in prostate cancer cells

2023

Journal of Men's Health

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Prostate cancer is a prevalent malignancy in men, necessitating the development of more effective treatment drugs. Alisma is commonly used in clinical settings for various ailments, including tumors. However, its mechanism of action in prostate cancer cells remains unclear. This study aimed to clarify the effects of Alisma orientale extract (AOE) on prostate cancer. Our results showed that AOE inhibited prostate cancer cell growth and induced apoptosis while promoting oxidative stress. Mechanistically, AOE modulated the p38/nuclear factor kappa-B (NF-κB) pathway to inhibit prostate cancer progression. Taken together, these findings suggest that AOE could serve as a potential treatment for prostate cancer.

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“…The ethanol extract of A. orientale had been proved to reduce the acute lung inflammation by suppressing the NF-κB [ 14 ]. Protostane triterpenes were the primary chemical constituents of A. orientale and exhibited a number of biological activities, such as antivirus, antitumor, hepato-protective, and anti-inflammatory activities [ 15 , 16 , 17 , 18 , 19 ]. However, there were few reports on anti-inflammatory mechanism of protostane triterpenes, except for inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated macrophages [ 15 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK, STAT3, and NF-κB Activation In Vitro and In Vivo

Wang

et al. 2017

Molecules

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Alisol F and 25-anhydroalisol F isolated from Alisma orientale, were proved to exhibit anti-inflammatory potential in our previous work. In the current study, the anti-inflammatory effects and action mechanisms of alisol F and 25-anhydroalisol F were investigated in vitro. Moreover, the pharmacological effects of alisol F in lipopolysaccharide (LPS)/d-galactosamine (d-gal)-induced acute liver-injured mice were evaluated. The results demonstrated that alisol F and 25-anhydroalisol F could suppress LPS-induced production of nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β), as well as inhibit the mRNA and protein levels of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2). In addition, we investigated the role of alisol F and 25-anhydroalisol F in mediating mitogen-activated protein kinases (MAPKs), signal transducers, and activators of transcription 3 (STAT3) and nuclear factor κB (NF-κB) pathways involved in the inflammation process of LPS-stimulated RAW 264.7 cells. The phosphorylation of ERK, JNK, p38, and STAT3, and the NF-κB signaling pathway, were obviously suppressed in alisol F and 25-anhydroalisol F treated cells. Results obtained from in vitro experiments suggested alisol F obviously improved liver pathological injury by inhibiting the production of TNF-α, IL-1β, and IL-6, and significantly decreasing the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in LPS/d-gal-induced mice. Furthermore, the reduction of phosphorylation of ERK and JNK, as well as suppression of the NF-κB signaling pathway, were also observed in liver tissues of the alisol F-treated mice model. Alisol F and 25-anhydroalisol F may serve as potential leads for development of anti-inflammatory agents for acute liver failure treatment.

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Alisol B, a triterpene fromAlismatis rhizoma(dried rhizome ofAlisma orientale), inhibits melanin production in murine B16 melanoma cells

Cited by 14 publications

References 30 publications

Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway

Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway

Alisma orientale extract inhibits cell proliferation by promoting oxidative stress and apoptosis in prostate cancer cells

Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK, STAT3, and NF-κB Activation In Vitro and In Vivo

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