“…Isotretinoin was the most common drug associated with depression with 57 reported cases, ahead of rimonabant, interferon, and efavirenz, all known depressogenic medications ( Lafay-Chebassier et al, 2015 ). Twenty three percent of ADRS for isotretinoin reported in France from 2012 to 2016 were for depression or suicidality ( Vrignaud et al, 2019 ). There were also four cases of violence or aggression (OR=9.5), a significant increase ( Rouve et al, 2011 ).…”