ALK-Positive Lung Adenocarcinoma Arising in an Adolescent Treated for Relapsed Neuroblastoma

Alwelaie, Yazeed; Deyell, Rebecca J.; Nadel, Helen; Tucker, Tracy; Laskin, Janessa; Rassekh, Shahrad R.; Zhou, Chen; English, John; Lee, Anna F.

doi:10.1016/j.jtho.2019.02.010

Cited by 3 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 Of the limited molecular studies of pediatric lung adenocarcinomas, ALK appears to be the most frequently reported gene mutated in this age group. 8,14,15 CTNNB1 codon 34 mutation was identified in our patient's tumor tissue. This mutation had been previously reported in patients with low-grade fetal adenocarcinoma of lung, 16 which as discussed earlier is characterized by the presence of squamoid morules.…”

Section: Discussionmentioning

confidence: 67%

“…[17][18][19] Absence of cystic dilatations or mucinous cells in our patient's tumor tissue is in keeping with the KRAS wild-type status in the tumor mutation panels. Most pediatric lung adenocarcinomas have been described in patients previously treated for various sarcomas, 1,7,8,20 potentially related to radiation exposure or a cancer predisposition. Our patient was previously healthy without family history of cancer.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Of the few reported cases, most of them were associated with congenital pulmonary airway malformation (CPAM) 5,6 or identified during treatment for nonpulmonary malignancies, most commonly a sarcoma. 1,7,8 Pediatric pulmonary tumors had identical histologic variants as their adult counterpart. 9 Cribriform lung adenocarcinoma is considered a subtype of lung acinar carcinoma by WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent

Razzano

et al. 2020

Pediatr Dev Pathol

View full text Add to dashboard Cite

Primary lung adenocarcinomas are rare in pediatric patients, and even rarer in patients without precedent malignancy or congenital malformation. Here we present the first reported case of primary lung cribriform adenocarcinoma with squamoid morules in a previously healthy adolescent female. Molecular testing identified CTNNB1 mutation in the tumor and excluded other common mutations in lung adenocarcinoma. Our case suggests molecular alterations to the same signaling pathway can lead to similar histomorphology regardless of the tissue of origin.

show abstract

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent

Razzano

et al. 2020

Pediatr Dev Pathol

View full text Add to dashboard Cite

show abstract

Primary lung adenocarcinoma in three adolescent patients affected by bone sarcomas

Righi

Vatrano

et al. 2021

Virchows Arch

View full text Add to dashboard Cite

Clinicopathologic and Molecular Characteristics of Resected Thoracic Mass Lesions in the Pediatric Population: A 25-Year Institutional Experience From a Tertiary Care Center

Villalba,

Terra,

Pitel

et al. 2024

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.— Primary thoracic neoplasms are rare in children, whereas nonneoplastic mass lesions or cysts and metastases are more common, and there is a relative paucity of comprehensive histopathologic and molecular data. Objective.— To define the clinicopathologic spectrum of neoplastic and nonneoplastic diseases observed in resected mass lesions in the chest of pediatric patients, and to identify somatic alterations observed in primary neoplasms. Design.— Clinicopathologic features of thoracic mass lesions (n = 385) resected from 373 patients aged ≤21 years in a 25-year period (1993–2018) were included. Primary neoplasms having sufficient material were tested by a laboratory-developed comprehensive genomic profiling assay that assesses tumor mutational burden, microsatellite instability, somatic sequence variants, gene amplifications, fusions, and specific transcript variants. Results.— The most commonly resected space-occupying lesions were nonneoplastic mass lesions and cysts or malformations, resected in 117 (31.4%) and 58 of 373 patients (15.5%) respectively. Metastatic neoplasms were observed in 169 of 373 patients (45.3%; mean age 14.4 years, range 1–21 years); the most common was osteosarcoma (68 of 169; 40.2% of metastases). Primary lung neoplasms occurred in 24 of 373 patients (6.4%; mean age 14.5 years, range 6 months–21 years), and 16 patients had primary extrapulmonary thoracic tumors. Carcinoid tumor was the most common primary lung neoplasm (7 typical, 3 atypical). Molecular testing showed a prevalence of somatic pathogenic or likely pathogenic mutations and copy-number alterations. No fusions or splice variants were identified. Tumors were microsatellite-stable with low tumor mutational burden. Conclusions.— Resected pediatric thoracic mass lesions are more likely to be metastatic lesions, congenital cysts or malformations, or nonneoplastic lesions compared to primary thoracic neoplasms, which are encountered at a low frequency and tend to have relatively simple genetic profiles.

show abstract

ALK-Positive Lung Adenocarcinoma Arising in an Adolescent Treated for Relapsed Neuroblastoma

Cited by 3 publications

References 3 publications

Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent

Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent

Primary lung adenocarcinoma in three adolescent patients affected by bone sarcomas

Clinicopathologic and Molecular Characteristics of Resected Thoracic Mass Lesions in the Pediatric Population: A 25-Year Institutional Experience From a Tertiary Care Center

Contact Info

Product

Resources

About